manu89's latest activity
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Mmanu89 reacted to IYIiKe's post in the thread Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients with.
https://www.advancedotology.org/en/tinnitus-suppression-with-electrical-stimulation-at-the-most-basal-contact-of-the-cochlear-implant-electrode-as-... -
Mmanu89 reacted to Nick47's post in the thread Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients with.@IYIiKe, I read this again, and I think it’s a well-thought-out point. Many new studies are using fMRI, EEG, and MEG to measure changes alongside...
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Mmanu89 reacted to Nick47's post in the thread Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients with.Dr. Hamid Djalilian Dr. Matthew Carlson Cochlear Ltd And Dr. Heidi Olze in Germany is still in the preclinical stage. I think this is the best...
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Mmanu89 reacted to gracepixie's post in the thread Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients with.Cochlear is currently recruiting for a clinical trial of a device that aims to quiet tinnitus via electrical stimulation of the cochlea via the...
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Mmanu89 reacted to LBE's post in the thread Tinnitus Suppression with Electrical Stimulation at the Basal Contact of Cochlear Implant Electrodes: Significant Improvement in 8 of 10 Patients with.It looks like Dr. Carlson’s trial at the Mayo Clinic is complete. Last year, they moved the expected completion date to the middle of next year...
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Mmanu89 reacted to Nick47's post in the thread Neuracle Science Initiates Phase 1/2 Clinical Trial of NS101 for the Treatment of Hearing Loss with.New pipeline candidate for sensorineural hearing loss (previously “undisclosed indication”), from Neuracle Science. A new Phase 1/2 clinical...
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Mmanu89 reacted to Frédéric's post in the thread Research's Attempt to Objectively Assess Tinnitus with.@Joeseph Stope, thank you very much for your compliments; I am very flattered. As I have already mentioned on this forum, it is thanks to a Google...
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Mmanu89 reacted to IYIiKe's post in the thread Research's Attempt to Objectively Assess Tinnitus with.To effectively study treatment outcomes, an objective standard of measurement is essential. Take CBT as an example. A new patient’s Tinnitus...
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Mmanu89 reacted to Nick47's post in the thread Research's Attempt to Objectively Assess Tinnitus with.Why they use mice, which are poor models for this condition, I will never know. Guinea pigs and gerbils are more standardized for auditory research.
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Mmanu89 reacted to Nick47's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Hi @Joeseph Stope, the idea is that these organoids will be organic and create an environment as similar to the human ear as possible. This aims...
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Mmanu89 reacted to Nick47's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.https://www.cilcare.com/2025/10/10/development-of-the-first-inner-ear-organoids-by-3d-bioprinting-for-pharmacological-screening-in-hearing-disorder...
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Mmanu89 reacted to Joeseph Stope's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.First living cochlea outside the body shows how hearing really works Some more euphoria for you all. Why am I bringing this up again? Well, I...
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Mmanu89 reacted to Fields's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Off-topic, but it doesn't really warrant its own thread, I think: Japanese scientists have found a way to naturally grow new teeth Medical...
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Mmanu89 reacted to lolkas's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Hello! If I am correct, the last update was around June or July of 2024, when an article was published on the NIH website about his work related...
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Mmanu89 reacted to Nocca's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Cilcare provides more details on its website about how the trials for CIL-001 will proceed. The Phase 2a trials are divided into three distinct...
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Mmanu89 reacted to Scruffiey's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Phase II trials are set to begin at the end of this year. I’m not familiar with Turner syndrome, but I would assume repeated applications of the...
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Mmanu89 reacted to Justin Mills's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Tinnitus is caused by cochlear synaptopathy. For example, if you go to a club without earplugs, the loud music can damage cochlear synapses...
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Mmanu89 reacted to Mdi's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Dr. Zheng-Yi is not only working on synapse restoration but also on the complete restoration of the cochlea, using your DNA as a blueprint...
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Mmanu89 reacted to Justin Mills's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Synapses are the most important to treat first because they are the most vulnerable. Before hair cells are damaged, it’s the synapses that are...
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Mmanu89 reacted to lolkas's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.I have been following regenerative approaches since 2016 and have observed many developments. The same applies to Dr. Susan Shore and other...
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Mmanu89 reacted to Fields's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.I forgot to mention it in my previous post, but Cilcare was also awarded €4.2 million by the French government. It'll be interesting to see where...
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Mmanu89 reacted to Fields's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Back in June, Cilcare and Shionogi announced an exclusive Option Agreement for innovative hearing disorder treatment. Under the terms of the...
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Mmanu89 reacted to gameover's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.Superior hearing would be like higher frequency range... it could create issues with some stuff. I'd gladly take this over tinnitus and fragile...
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Mmanu89 reacted to Muggumbo's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.I'd take it even if it was a suppository!
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Mmanu89 reacted to Fields's post in the thread Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration with.I personally thought this was a little funny: Imagine going from hearing loss and tinnitus on one end of the scale to not being able to sleep...
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MWhether it is through Tinnitus Quest or simply because the world is getting louder and more people are suffering from tinnitus, or possibly both...
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MAs @Nick47 pointed out, it isn't just auditory-related illnesses, but several other areas of medicine and research don't translate well due to a...
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MCould you elaborate on why animal models translate poorly to humans? I remember reading about Harvard Medical School’s research into regrowing...
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Mmanu89 reacted to NewLionel's post in the thread Prototype Device for Electrical and Magnetic Stimulation of the Ear in the Treatment of Tinnitus with.I always knew the cure would be magnets...
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Mmanu89 reacted to addot's post in the thread Prototype Device for Electrical and Magnetic Stimulation of the Ear in the Treatment of Tinnitus with.Great find! Thanks for sharing. It seems like a lot of electrical/magnetic ear stimulation treatments are popping up: Dr. Hamid Djalilian is...
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Mmanu89 reacted to InNeedOfHelp's post in the thread Prototype Device for Electrical and Magnetic Stimulation of the Ear in the Treatment of Tinnitus with.Often with long studies you have primary endpoints (reached after several months) and secondary endpoints reached much later, with readouts in...
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Mmanu89 reacted to InNeedOfHelp's post in the thread Prototype Device for Electrical and Magnetic Stimulation of the Ear in the Treatment of Tinnitus with.Assessment of Subjective Tinnitus Treatment Results Using a Prototype Device for Electrical and Magnetic Stimulation of the Ear-Preliminary Study...
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Mmanu89 reacted to Nick47's post in the thread Prototype Device for Electrical and Magnetic Stimulation of the Ear in the Treatment of Tinnitus with.It would be interesting to find the degree of hearing loss and response rates. Looks very impressive!
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MYeah, TUS is emerging as a pretty interesting technology. It has way more spatial specificity that other stimulation technologies, and can also...
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MI have been looking at this today and wondering what people’s thoughts are. If we take the premise that it has been shown to reach deep brain...
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Mmanu89 reacted to Jinx's post in the thread NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss with.It looks promising, but they are measuring over a time span. I wonder if it will also be helpful for people who have already had it for a long time.
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Mmanu89 reacted to Ozhe's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.Lineage Cell Therapeutics has entered into a three-year collaboration with William Demant Invest (WDI) to advance the preclinical development of...
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Mmanu89 reacted to Greg Sacramento's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.It is. It sits at middle of biotech scale with analysts. Dry age-related macular degeneration and cell therapy are very crowed research areas...
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Mmanu89 reacted to Geatly's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.They aren't a failed biotech. I checked them out, they are pretty successful from what I read about them.
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Mmanu89 reacted to DimLeb's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.I think yes, tinnitus is one of them. Since any damage to the auditory path can cause tinnitus, then it's most likely.
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Mmanu89 reacted to katri's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.2022 has been the year of optimism for me so far. A couple of years ago things were so dark but all of the research going on is giving me comfort.
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Mmanu89 reacted to Geatly's post in the thread Lineage Cell Therapeutics — ANP1 for Treatment of Auditory Neuropathy with.I wish that in 5-10 years most of these biotech companies would have their medicine on the market. Life with just slight hearing loss and tinnitus...
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Mmanu89 reacted to Nick47's post in the thread The Evaluation of Memantine Effect on Tinnitus Severity with.It was a moderately sized group, and the results look impressive. Would a group of 200 participants still show this level of significance? It...
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Mmanu89 reacted to Joeseph Stope's post in the thread AudioCure AC102 to Treat Hearing loss and Tinnitus with.The modern world is becoming louder rather than quieter, increasing the risk of further hearing damage. Whether due to acoustic trauma, aging, a...
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Mmanu89 reacted to Scruffiey's post in the thread AudioCure AC102 to Treat Hearing loss and Tinnitus with.I don’t know about you, but I’ll be glad to know that if my ears aren’t protected for some reason one day, there will be something available to...
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Mmanu89 reacted to Wolfka's post in the thread AudioCure AC102 to Treat Hearing loss and Tinnitus with.Almost a year later after the last post :) This really keeps me hopeful.
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Mmanu89 reacted to Nick47's post in the thread AudioCure AC102 to Treat Hearing loss and Tinnitus with.I agree. Rinri Therapeutics are taking the auditory nerve approach as are Hough Ear Institute. There are recent findings on auditory nerve damage...
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Mmanu89 reacted to Justin Mills's post in the thread Tinnitus — Current Developments: Overview and Summary of Current State of Knowledge in 2024 with.Timeline for Regenerative Treatments in Cochlear Synaptopthy (tinnitus/hyperacusis) I've attached the result of my deep research results timeline...
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MA more realistic statement would be: “For some people, tinnitus can get better over time, and it often depends on the root cause of their...
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Mmanu89 reacted to Joeseph Stope's post in the thread The Trump Administration Canceled a Hearing Loss Researcher's Grant with.To my dismay (or perhaps excited outrage), my summary was not clear enough. The researcher in question was born nearly completely deaf, yet...