Glutathione

This substance is said to be a very powerful antioxidant that our bodies are capable of making. It can be bought as a supplement but one of its components is Glutamic Acid. As has been discussed in other threads Glutamate is thought to be responsible for excitotoxicity in the auditory cortex.

I just wondered what people's thoughts are on taking this supplement? Would it result in more Glutamate, or would this not be a problem because it's bound into the Glutathione?

 

I had Glutathione as part of my intravenous Vitamin C detox whilst having my mercury fillings removed. I had 4 IVs over 3 days and also had the Glutathione as part of a multi-vitamin powder supplement for a 6 weeks afterward. Sadly it had no effect on my tinnitus at all.

 

Raising the bodie's Glutatione levels via supplementation isn't easy.

Why?

Because most pill, capsule, or powder supplements are broken down in the gut and never make it into the blood stream or the cell where it is needed to work its magic.

Trying to maintain a diet that will give you what you need from food today is also challenging. The nutrients of our food today, compared with that of 50 years ago is very different.

As the quality of our food decrease the number of those impacted by deiase is increased. I thought this was an interesting chart:


So we have to try and eat better quality foods (organic stuff) things that are locally grown and in season are best. Then we have to select high quality supplements that are destroyed in the digestive system failing to make it into the blood stream or cells.

I recommend a specific supplement for raising Glutatione levels in the body because of the RiboCeine compound it is build from.

 

So, has anyone else here tried IV Glutathione?

I was floxed last year with Ciprofloxacin.
It is loaded with fluoride just to ensure it penetrates the central nervous system effectively!

My doctor wants me to trial IV Glutathione along with iodine in an attempt to remove fluoride.
Anyone else tried this?

Thanks.

 

I don't see how IV glutathione could reverse your tinnitus. But it shouldn't hurt you, and it may reduce your noise. If you do it, let us know what happens. Perhaps, your physician is onto something that might mitigate your specific type of tinnitus. I am assuming the tinnitus resulted from the cipro.

Here's a link to IV glutathione from an IV center:

http://ivtherapycenter.com/IVGlutathione.cfm​

And here is general information on glutathione:

http://www.webmd.com/vitamins-suppl...717&activeIngredientName=glutathione&source=1​

I did find an interesting abstract on cipro and glutathione levels. I'm not sure it's helpful but I'll post it:

Drug Chem Toxicol. 2004 Aug;27(3):233-42.
Ciprofloxacin-induced glutathione redox status alterations in rat tissues.

Abstract
The possible oxidative stress inducing effect of a fluoroquinolone (FQ) antibiotic, ciprofloxacin (CPFX), was investigated in rats measuringglutathione redox status. For this purpose, the drug was administered to rats as two different single doses (100 and 150 mg/kg, ip) or a repeated dose (500 mg/kg/d, ig, for 5d). Then, total and oxidized glutathione levels were determined in hepatic and cerebral tissues of the rats by an enzymatic cycling assay, and the glutathione redox status was calculated. The possible protective effects of vitamin E or allopurinol against CPFX-induced alterations on glutathione system have also been examined. Following both routes of administration of CPFX, the total glutathione content of the liver, but not of brain decreased significantly. The oxidized glutathione (GSSG) in the brain increased after single or repeated dose treatments, but only with repeated doses of CPFX in the liver. CPFX induced dose-dependent alterations in the glutathione redox status in both tissues. With single doses the effect was more pronounced in cerebral tissue, and with repeated ig doses it was significant in both tissues. Pretreatment of rats with vitamin E or allopurinol before the administration of CPFX provided marked protection against glutathione redox status alterations in both tissues. Our results, thus, indicate that CPFX treatment introduces an oxidative stress in cerebral and hepatic tissues of rat.

Reference: http://www.ncbi.nlm.nih.gov/pubmed/15478945​

 

I've had two Glutathione IV's in an attempt to reduce my tinnitus, with no effect thus far. The first was 600 mg and the second, four days later, was 1200 mg. I'll probably have a third one this week. I have friends who had Glutathione therapy for neuropathy and they report that it took a few treatments for them to notice improvement.

One of my hesitations is that Glutathione IV therapy is not cheap: it's $125 per IV session where I go. Yes, I understand that there are costs associate with administering an IV, but it's a bit frustrating to pay $125 for about $1 worth of Glutathione.

 

Update: I had my third Glutathione IV treatment a few days after the above posting. 1200 mg. No change detected.

 

I am replying to this old thread because I am currently taking Glutathione after an ENT prescribed me for my tinnitus. When I asked him what Glutathione was supposed to do he answered that it can be used to stabilise old acoustic traumas since at this point steroids would not have any effects. The prescription is 3 cycles of 10 intramuscular injections (1 per day), each cycle to be taken every 20 days. The medicine is called TAD 600 (600mg of Glutathione).

It did not have any effect on my tinnitus in terms of loudness but maybe it is having some kink of effect on the ears. I just got a checkup at work which included hearing test and the audiogram for one ear looks better than the one I got in Christmas, could probably be due different instrumentation measurements. Anyway I am in the middle of the second cycle and I will update here in case of any change in my condition.

 

Has anyone considered taking sublingual glutathione, rather than NAC? Supposedly it can be absorbed directly into the bloodstream this way.

 

I'm switching from NAC caps to liposomal glutathione liquid and PharmaNAC. I'll post an update soon.

 

I still want to get the sublingual glutathione but it’s on the expensive side.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536296/

I don’t trust the effectiveness of NAC capsules or tablets anymore. Every time the bottle is opened moisture in the air is going to get in a degrade it. Moisture absorbers only do so much. The pharma nac is in individual foil, right? I used to take something like that until I decided I didn’t feel comfortable with the brand I was taking contained aspartame. I’m sure they all don’t.

 

You're right. NAC caps are prone to oxidation. PharmaNAC has effervescent tablets that are individually wrapped. I'm not sure about the aspartame. Liposomal glutathione is probably just as good as the sublingual. It bypasses degradation in your stomach and is absorbed straight into the gut. I'm trying both.

 

Hi Debbie. I was floxed in 2016 which made my existing tinnitus worse. I debated the Glutathione option as well.

Just wondering if you tried it and if it had any effect on tinnitus?

 

Hi,

I did try it.

Made no difference to tinnitus.

Sorry to hear you've been floxed too.

 

Has anyone tried taking Glutathione with Selenium in an attempt to replicate the beneficial effects of Ebselen?

 

Glutathione is not the same thing as Glutathione peroxidase. You wouldn't be mimicking the effects of Ebselen.

Same with regular Selenium. Ebselen has selenium in the molecule but it's not plain Selenium. It looks like this:

 

Ah ok. Thanks for explaining. Back to the drawing board!

 

Thanks for your reply. Floxed and tinnitus is an impossible maze. 2 years in bed with tinnitus getting worse and Ciprofloxacin destroying my body. Never ends.

 

How are you doing?

 

Thanks for asking. Honest answer, still just alive and still visiting this forum so life has been better. A hearing aid and various supplements over the years have helped me cope but yet to find anything that significantly brings the noise down. It's strange that smoking pot can make it go crazy but CBD has no effect on it.

I read your post about fleeting tinnitus. Mine does it every once in awhile. I actually don't mind as it's the only time the noise changes, then after about 10-20 seconds it goes silent just for a moment. It at least gives me hope that it's possible to experience silence again. Also, every so often it will just stop for a moment, for less than a second. I try to recreate any movement I was doing at the time but have never found a way to have any control over it.

 

I've read online about people getting floxxed and met a woman who had it happen to her. I feel like there's so much that the medical community still doesn't understand. Like with Long COVID-19 now, finally they are realising that chronic post-infection symptoms are common (like CFS, and the like). I hope what happened to you, and tinnitus and ototoxicity gets more attention.

Thank you for your input about the fleeting tinnitus. It still scares the shit out of me, to be honest. It's so unsettling. Sometimes, I get these one second cut-outs, too, where my tinnitus is gone for a second, but that isn't what scares me, it's the dull/muffled feeling during the longer episodes.

I have a huge somatic component to my tinnitus, do you?

 

Apparently coffee enema allows your liver to produce glutathione up to 6 to 7 times more.

 

And with those increased increased glutathione levels comes many benefits. It was reported in a 1922 New England Journal of Medicine article that coffee enemas are very helpful for many people with depression. CEs are also able to dramatically reduce a variety of pain syndromes for many people. A possible alternative to CEs would be to do nebulized glutathione, which has also been purported to be an effective adjunctive treatment for COVID-19.

 

I'm sold. COFFEE ENEMAS FOR EVERYONE!!!