Artemis2K

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1165-5#:~:text=During%20this%20process%2C%20pluripotent%20stem,to%20the%20desired%20cell%20type

Perhaps this is why the Frequency Therapeutics molecular therapy didn't work? The cochlea doesn't seem to have a good natural source of growth factors or nutrients, otherwise ribbon synapse and stereocilia would heal easier.

Ok now I'm starting to consider stem cells first and then PRP as a follow up. My bank account is going to be so empty until the second quarter of next year lol.

@Ryan Scott There have been studies on both humans and animals, one of which included children. Most of them have focused on SSHL as an alternative to steroids. There's one study that has people who had success despite 10+ months of damage.

@GeraldHenders "Stem cells require a mixture of growth factors and nutrients to differentiate and develop. The medium should be changed each day." https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1165-5#:~:text=During%20this%20process%2C%20pluripotent%20stem,to%20the%20desired%20cell%20type.

Maybe this is why the molecular therapy failed.

@Ryan Scott
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9449904/

@Artemis2K Has any of the Drs. who provide PRP, blood injections into people's ears ever discuss it, or say why not? Seems illogical not to, with the potential benefits.

@sakrt What do you mean? Why aren't there more SC/PRP clinics doing IT-injections? Probably because it's not skin/muscle/skeleton related. Interior related treatments can make the FDA suspicious.

Tinnitus implant system, based off of cochlear implant. That would be the “next” thing that would hold true promise for those with tinnitus rooted from a cochlear source like hearing loss/damage. Hopefully the current trial is on pace and will be completed with results in June.

That's good, but that's just half of my issue I'm afraid. I have a hearing loss notch in my left ear that makes focus and conversation very difficult, despite it not being bad enough for hearing aids.

Believe me, I know ;( Let me know if you talk with a clinic about your approach and what they say!

What's your answer?

IGF-1 extracted from PRP that is at least 150 micrograms. There are numerous studies showing that IGF-1 is capable of so much for the cochlea, but having a foreign variant of it is both expensive and dangerous, while from PRP is just expensive. The objective is to have a pure form of it so there is no dilution disrupting the potential effects.

I feel our medical insurance should be assisting, allow this for sufferers to try, when there's really no other option, except narcotics. IF it was covered under some approval agreement, the medical system would be able to collect data to know if truly effective. In the long run, if positive, would decrease the huge health and disability burden. Reality is, most cannot afford this, and very expensive health ins.!

Which one?

Wow, great finds and points @Artemis2K , how would someone even go about bringing something like this to a research institution’s attention? Furthermore, would it even be worth discussing with those who are already doing stem cell / exosome protocols? Like I wonder what StemCell21 would respond with.

As for America, my experience with that clinic in Charlotte made me more worried about the willingness of experimentation from stem cell clinics, especially the ones that specialize in the sports injury treatments. They'd probably be worried about being in trouble with the FDA since IGF-1 is illegal for professional sports use. IGF-1 is approved for other genuine conditions though... @ErikaS

@ErikaS I've never tried to get an institution's attention like this. I probably wouldn't be able to do that alone. They'd probably write me off as a nobody lol. I'm really willing to try though. To be honest IGF-1 has been in discussion for about four years now. I kind of wish I had this idea back then. Then again, we didn't know as much about stereocillia, support cells, and ribbon synapse as we do now.

We need science to evolve. Evolution is too slow.

My cat does a better job to be fair

How much hearing? I’d try and get in touch with an ENT asap if I were you

@CRGC Not very much. Five decibels. I would be going to an ENT but I cannot afford to right now. Have to stick to my supplements and hope they do something. I haven't felt sick, don't recall loud noise, and don't listen to too high of volume.

I think a fluctuation like that has good chances of sorting itself out. Good luck!

I usually don’t go into 70dbs noise without my musician earplugs. At least a 10db filter.

I need earplugs if it's any louder than 60db