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The study failed and they kind of abandoned the product. Decibel Therapeutics, Otonomy and maybe in the future Stanford Initiative to cure...

Decibel Therapeutics and Otonomy... These are the companies to focus on now. If I understand correctly, even in the 8-16 kHz, no hair cell...

I agree, however they will probably have to do Phase 2 again with single dosing? This means another 2 years of delay...

After following this thread and company for more than 4 years, we will finally get the answers in the coming weeks. It's exciting for sure.

I created my account here 3 days after this thread was started, it has been a dream since then. Good thing is, when I started reading about hair...

There's a difference between staying positive and false hope. It just won't happen, that's a 100% sure.

Seems like you don't understand the difference between the real economy and the stock market, go read some books.

Agree, especially things like daily stock fluctuations are literally adding zero value to the discussion here. I mean, the stock will go up and...

Look at the phase 1 results: Some results from the word recognition test: 14/50 to 34/50 20/50 to 39/50 26/50 to 47/50 Of course you notice that...

What's the other one?

What's the time frame between the different shots?

I would only go until Q4/2020, when Otonomy releases results of the hidden hearing loss treatment phase 1 trial :)

Of course he's conservative. Management from publicly listed companies is always conservative, they risk law suits if it turns that their...

Correct, but it seems there is a lot of movement in this field. I came across this paper from 2020:...

Considering that some of the phase 1 subjects had substantial word recognition improvement while the drug (in their dose) only seemed to target...

Exactly, I am confident that they will be able to develop a delivery method to distribute the drug across the entire cochlea. It would expand...

Entry price doesn't matter too much here. If FX-322 will get approval, it doesn't matter whether you bought at 22 or 15 as the stock price will be...

Happened to me a couple of times since onset, usually goes away after a while. Nothing to worry about unless it doesn't subside even after hours.

Might be but I would travel to any place in the world if it could give me some relieve and improved hearing.

Just out of curiosity, what was your word score? If it was really bad, they may think there aren't enough support cells left to regenerate...

Remarkable statement considering that we don't yet know how Otonomy will try to restore hair cells. AFAIK it's pre-clinical and more information...

Considering that there are no solutions to hearing loss at this moment (except for hearing aids which don't tackle the root cause), I am pretty...

Couple of comments as someone with a finance background, six figure amount invested in the market and always happy to give some investing advice:...

Quite a disappointment, have been following them for years and the hope for hair cell regeneration helps in keeping my mental health under...

Let's be patient, 30th of April is an estimated timing. I would be worried if they didn't release it by end of July, not 6 days after an...

It's smarter to short FREQ, then you win in both scenarios. If the therapy works, you will get hearing improvement/lower tinnitus and if it...

Probably more clever but not necessarily more effective... We will see :)

They are not from that study. The CI study was in Australia, the ones discussed here is phase 1 conducted in the US. I hate the negativity here,...

http://www.otonomy.com/pipeline/hearing-loss-programs/ OTO-413 (BDNF) OTO-413 is a proprietary, sustained-exposure formulation of brain-derived...

Phase 1 will start later this year I believe.

Maybe that's what Otonomy is going to use for the upcoming hidden hearing loss clinical trial?

As per Audion therapeutics: Other interesting quotes: => It means they believe it could still work after 20 years of damage, that's a very good...

It's completely normal that different doses are tried during clinical trials... Yes they wouldn't do that if a single dose restored 100% of the...

Won't these new hair cells also have ribbon synapses that can cover up for the lost synapses in the other hair cells? That's why I think it could...

Why is everyone so excited? Nowhere is mentioned that they will already present phase 1 results at this conference (there are more than 450...

Why wouldn't it be safe? I used them for my MRI.

Has to do with failed Meniere's drug in phase 3, nothing to do with its preclinical research on hearing loss.

First weeks after the spike that made my tinnitus very very bad: 1-3 hours per night. Took me up to 6 hours to fall asleep. Nowadays I sleep 7-8...

Some of you don't understand economics. At least 300 mil people have considerable hearing loss, more profitable to treat them all at $1k than just...

Slow? This is really how clinical testing works. This trial is advancing in line with the expected timetable.

I don't think it is reasonable to expect that tinnitus will completely disappear with hair cell regeneration. Hair cell regeneration will simply...

Has been extensively tested in mammals and no such occurrences.

I own several biotech companies but at this point Otonomy is indeed too speculative. If one of their hearing loss programs show efficiency in...

Lol do you know anything about stocks? First of all, your comparison with Auris does not make any sense. Secondly, all depends on their ability to...

http://investors.otonomy.com/static-files/2b7ed6d7-7056-48e2-ad6c-f5aeace058e9 Was looking at the Otonomy presentation of August. Slide 19...

Negative? I only see positive things except for the "sketchy" company remark.

In some other press releases such as the requirements for the phase 1/2 trial they also mention that SSHL and other causes can be eligible for...

Has been mentioned several times by Frequency that not only people with acoustric trauma are included, but also people with SSHL due to other...

It will not damage your ears, probably about 80-85 db max. I am happy if it rains while being in the car, it's a good mask for my tinnitus.

Some positive factors in my opinion: - People up to 65 year old can participate => indicates that the drug will not only benefit young people as...

These 12,000 views are not all unique views I believe.

Please continue the conversation in private message.

It mentions there were no adverse effects in the animal testing, very promising.

I take it more as a preventive measure. I already have some hearing loss, by taking NAC I hope to avoid any further loss which in the end should...

I take it daily since more than a year ago. 600 mg in the morning and 600 mg in the evening. Sometimes when I am exposed to loud noise/day I take...

They are linked because both are supposed to be filtered out by the brain. Thats why people with T often have floaters and VS as well. Sometimes...

Its crazy how you can go to gig after gig without any impact and then one more makes your T 5 times worse, got tbe same. We were not really given...

In that case Frequency could pay Novartis to make use of their delivery method.

This thread is about hair cell regeneration. This will not make your tinnitus disappear as they will not be able to regrow all lost hair cells....