Separate names with a comma.
No idea so far. They may announce study completion date once the Phase 3 trial for BHV-7000 starts. I’m hoping the trials for BHV-7000 will be...
Biohaven Announces Positive Data from its Exploratory Electroencephalogram (EEG) Biomarker Study of BHV-7000, Completion of Once-Daily Formulation...
Which one works better for your noxacusis, Tegretol or Keppra? Did you ever try Gabapentin?
I agree we have no definite proof on whether BHV-7000 or XEN1101 could help with tinnitus and hyperacusis/noxacusis but there was a presentation...
@alanisnotadj what was your dosage per day and when did you take it?
@alanisnotadj did the gabapentin help with the instant stabbing pain from noise or just the aching and burning pain?
@alanisnotadj what do you mean by permanent pain? Are you talking about the aching pain 24/7 after noise exposure?
@alanisnotadj you mentioned gabapentin helping with your hyperacusis/noxacusis. Did you have stabbing, aching and burning pain from noise? Which...
Same, these Kv 7 potassium channel opener drugs seem to be the key in reducing tinnitus and hyperacusis/noxacusis. Especially since these Kv7...
Maybe we need a combination of Dr. Shore’s device and BHV-7000/XEN1101 potassium channel opener drugs to get rid of tinnitus and...
That seems to be the case. They also mentioned in their presentation slides a while back about which potassium channels they target and by how...
That’s a good point about tinnitus rarely being expressed directly at the hair cells in terms of Kv7.4. We know that some people who suffer from...
Someone on Tinnitus Talk emailed Biohaven asking if they were going to test BHV-7000 out on tinnitus patients. I think the reply was along the...
They most likely know about tinnitus reduction happening from patients taking Trobalt in the past. Whether they want to test it on tinnitus...
Having both XEN1101 and BHV-7000 being each other’s competitors, there is more of an incentive on getting these Kv7 potassium channel opener drugs...
[ATTACH] [ATTACH] For those of us who suffer from reactive tinnitus or hyperacusis/noxacusis. I’m waiting for Biohaven to announce when they...
I still haven’t decided who is going to come out first between XEN1101 and BHV-7000 as Biohaven haven’t even started their pivotal phase or stated...
Do you suffer from hyperacusis/noxacusis? If you do, did Trobalt work for your hyperacusis/noxacusis as well?
Maybe but I think tinnitus and hyperacusis/noxacusis reduction was more because of the Kv7 potassium channels, particularly Kv7.2 and Kv7.3. We...
How are you making the Ginger tea? Do you boil water and then tip it in the cup or do you boil water with the Ginger inside? If you have any...
@MadeleineHope, @haha ear go eeee, do you know what may be the difference between Ginger capsule supplements (Ginger root) vs. actual Ginger?...
That seems to be the case. I wonder what the difference is between Trobalt and other anti-epilepsy drugs out in the market. If these new...
I think XEN1101 will definitely pass the Phase 3 trial, and BHV-7000 too unless there were severe side effects with more people in the trial. I...
From the Trobalt User Experiences thread it seems most people's tinnitus was reduced while on it. On the other hand, hyperacusis/noxacusis seems...
Any reason why neither BHV-7000 nor XEN1101 have received Breakthrough Therapy status or FDA Fast Track yet? XEN1101 is currently in Phase 3 trial...
So this is essentially a sodium channel blocker targeting NaV1.8 sodium channel (pain receipt) in the brain. What would be the difference between...
@Nick47, @StoneInFocus, I know this is an old thread but I wanted to get your opinion on what you reckon is causing hyperacusis/noxacusis; Kv...
Basically due to it being off-label and no prior experience in prescribing Tegretol for hyperacusis/noxacusis. I may try a neurologist if I can’t...
@MadeleineHope, did you find out what type of cilantro/coriander was used? I tried to ask my doctor to prescribe me Tegretol but they wouldn’t let...
What was your tinnitus level before and after taking Trobalt?
X-TOLE2 Phase 3 trial has a study completion of June 2025. X-TOLE3 Phase 3 trial has a study completion of December 2025. I believe the study...
Xenon Pharmaceuticals Reports Second Quarter 2023 Financial Results and Provides Corporate Update
@MadeleineHope, what type of cilantro/coriander should I get?
I haven’t thought of trying plants, but it would not be possible to get Epidiolex in my country. It would be nice if these potassium channel...
This is interesting. We were talking about how Kv7.5 might be causing the severe side effects with Trobalt but ginger may be helping with the...
I might give Clomipramine or Tegretol a go. Which one should I try first? Can they be taken with an SSRI antidepressant?
To think people who go to clubs and concerts don’t wear earplugs is astonishing. If I had known that these conditions existed I would have...
It’s ridiculous that we are unfortunate in getting tinnitus, hyperacusis/noxacusis. Before getting these conditions I knew loud noise could cause...
Xenon Pharmaceuticals Announces Conference Call and Webcast to Discuss Second Quarter 2023 Financial Results and Provide Corporate Update August...
@StoneInFocus, @grate_biff, I see that Tegretol is an anti-epilepsy drug. Is this similar to Trobalt? Do they both open Kv7 potassium channels?...
Can you take that everyday or does the effects of the drug wear off the longer you take it?
I know Xenon Pharmaceuticals aren’t offering compassionate use. Biohaven might when they start the pivotal phase but who knows. I don’t live in...
Did you get a reply from Norena on whether potassium channel openers might work with noxacusis? Did you ask them specifically what Kv7 potassium...
I would say mild tinnitus is where you only hear it in a quiet room with no sound on
If there are drugs that help with noxacusis/hyperacusis right now, can you please tell what those drugs are, describe what the patients'...
Do you find you can tolerate more noise with Gabapentin or does it only reduce the pain?
I agree with you that no one in the Trobalt User Experiences thread mentioned the term noxacusis so we are uncertain if it can help or not. Maybe...
I’m not sure but I feel like Biohaven’s BHV-7000 will more likely offer compassionate use than Xenon Pharmaceuticals due to it being bought out by...
We should know by next month who is ahead of releasing these Kv7 potassium channel openers first. Xenon Pharmaceuticals will provide a quarterly...
So this thread is interesting. I see the mention of calcium blockers helping with noxacusis. I still reckon BHV-7000 and XEN1101 are more likely...
When I first heard the stock drop by a lot, I thought something bad had happened with BHV-7000.
If your tinnitus seems to react to noise I wouldn’t do it.
What trial is this?
Biohaven Provides Preliminary EEG Data Update for Kv7 Platform, Regulatory Update on Troriluzole and Other Corporate Updates For the Phase 2/3...
No idea but BHV-7000 is supposed to have its pivotal Phase 2/3 trial start in 2H 2023 and it may be quicker to come out due to Pfizer buying...
[ATTACH] This is a good diagram from Biohaven presentation slides on the potassium channels and where they are on the body. From the 2015 case...
Whereabouts in the study does it specifically state that Kv7.2 and Kv7.3 were the potassium channels that were open? I can’t seem to find it in...
If the theory of suppressing the type II afferents' response to hair cell damage is true, then it seems hyperacusis/noxacusis is going to be more...
@grate_biff, did Biohaven reply to your email? Any idea when they might start the pivotal Phase 2/3 and how long that trial will take? Reading...
Not yet. Pfizer/Biohaven BHV-7000 is going to move onto the pivotal phase 2/3 which should start 2H 2023 but not sure how long that trial will...