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One day ‘machine learning algorithms’ will solve tinnitus. I got excited when I saw the title.

Seroquel at 12.5 mg does not work as an antipsychotic and will only touch histamine receptors and not go near dopamine. Mirtazapine at 7.5 mg has...

I can only empathise. The stress of the birth of my 23+3 twins caused mine. There is nothing worse than having suicidal thoughts when you only...

Thanks. Awesome explanation. Quick question: Many report tinnitus worsening from benzo withdrawal is temporary. Do you agree with this? Once...

No. Only two phases for medical devices. They will have to get FDA approval. The process is under the DeNovo pathway. Details of that are here:...

I know, but EU CE is even more relaxed and shorter timeframes than FDA rules for Grade 2 devices. Depends a lot on who is interested in...

Hi Ben, It’s pretty basic. Benzos increase GABA which decreases neuroexcitability. The ‘opposite’ of GABA is Glutamate. When you take Benzos,...

That is why I wouldn’t rule out a EU release before a US one. A CE would be faster to achieve than FDA approval and the treatment isn’t ‘novel’...

Trying to figure out the commercialisation strategy here. Basically Auricle is a company set up to commercialise Dr. Shore’s work BUT: 1.) Is it...

Had it not started yet? Ah well. That is the game changer. I really don’t know why they keep flogging a dead horse with FX-322 but hey that’s just...

Best of luck with your surgery! Internal derangement sounds pretty bad but I’d imagine most tinnitus sufferers have another form of ‘internal...

Yea, absolutely fair play to everyone that went, did the treatment and reported back. Truly full of admiration. Hoping Tom gets relief. I know...

I mentioned your case to Dr. Brendan Conlon of Neuromod (Lenire) and suggested that many would be prepared to pay a lot of money for this intense...

Park this thread for 7 years. The whole brain tech landscape will have changed by then. Actually you should just delete this thread.

Your story is similar to mine. I am genuinely suicidal. I have a plan, etc. I’m hoping that improving my mood will give me resilience. However, I...

Just for a clean trial. I suppose GAD for example could affect before and after scores. I don’t think it intends to stigmatise mental health but...

Legend. Sounds like you have been through a lot buddy. Fair play to keep going. I’m definitely going to ask them to take it slow. 5 mg Lexapro as...

Thanks for taking the time to write this up for me. Really appreciate it. I’m tending towards Lexapro as I am switching from Paroxetine....

Apologies for not getting back to you yet Deb but mojo is low. From my research Quercetin hits the Kv 7.1 channel, not the Kv 7.2 channel. Hope...

What is the best of a bad bunch antidepressant wise? I know from research that the antidepressant I was put on, Paroxetine, was the worst. From...

I was on Clonezapam for only 4 months. I have switched to Diazepam and am currently on 15 mg. My story is complicated and involves a breakdown,...

Thanks for the reply. I’m actually going for a lengthy inpatient stay for depression and I’m not going to allow them to cut me off too quickly....

Switched Clonezapam (1 mg) to Diazepam (20 mg, and down to 15 mg now). Going to detox and withdraw as an inpatient. Has anyone had a relatively...

Exactly my story. Useless Psychiatrist. Not a clue. Now having to revisit SSRIs as depression is crippling.

There is really only anecdotal evidence from the Trobalt User Experiences thread. It is a massive decision for you especially after your brave...

No depression trials in Europe but there will be epilepsy ones.

Absolutely your choice my friend, but I’m jealous you have the chance!

You should have a thorough read but focus on those who tried the correct dose for a longer period. Not the users on small doses or changing doses....

Really can’t be bothered, but if finding ‘evidence’ to satisfy yourself that it won’t help tinnitus floats your both then fair enough. For me the...

No offence but the user asked the question of me, not you.

If you really go through the Trobalt User Experiences thread with a fine tooth comb and focus on the users that used Trobalt at c. 900mg...

One board member was accepted but due to hyperacusis was wary (understandably) of the required MRI.

Just adds more evidence that CNS hyperexcitability and deficiencies in the ion channels are a MAJOR cause of tinnitus. Good find.

I firmly believe that tinnitus will be solved by engineers rather than anyone involved in medicine. No one can convince me that this is not just...

So true. I just think there is no comparison between Dr. Shore's device and Lenire. Lenire does not target a physiological cause of tinnitus....

Taking a break from this thread now too until there is new information to post. Why negativity? SPI-1005 is targeting both Meniere's and NIHL....

Look, if you go to their website, you will find they are targeting NIHL and associated tinnitus with SP-1005. This is in addition to Meniere's...

This device is NOTHING like Lenire. Lenire does not target any physiological cause of tinnitus. The University of Michigan device does. Yes...

Similar situation here. No one knows unfortunately. Prof. Shore said we must be ‘patient’.

I’m outta here for another bit. Will continue to update this thread with news from Xenon Pharmaceuticals when it comes out.

The compound is a potent anti-inflammatory so it treats inflammation, hence the hope it might help general tinnitus.

Depends on what research you read.

Going through those graphs gives me immense hope regarding tinnitus loudness reduction. Active outperforms Placebo by a wide margin. I’d also...

Yes, there is a dramatic decrease in efficacy as regards reducing tinnitus loudness once treatment is stopped.

As some others on here, I have tried every means known to me to contact Prof. Tzounopoulos and his team, but he will not answer a very specific...

The clinical trial is 1 year. Fast track NDA 6 months. Guess is 20-24 months.

30% reduction in tinnitus loudness vs 10% of that in placebo.

Just an interesting find. One of Sound Pharmaceuticals’ advisors is a former Nobel Prize winner for Physiology and Medicine. Wikipedia: Bruce...

Not sure if this was posted before, but here is a chart summarising Phase 1 Results that is easy to digest. I guess the ‘hope’ is that steep...

That is exactly the hope, however, I don’t agree with you as regards Clinical Trials. First Target equals primary efficacy of Focal Epilepsy and...

No, they will file for Focal Epilepsy first using the Phase 2 plus OLE and the Phase 3 data. In the Fireside chat the other night, they indicated...

To be completely honest, he really kind of brushed off the question a little and was very casual about it. The document itself is excellent...

I spoke to Professor De Ridder about this on the 1st of August. It is on hold until he returns to Europe from New Zealand. I don’t know when that is.

Honestly been a rough time since April and still is. That is the nature of the beast, isn’t it. Back to Tinnitus Talk after a break. Really hope...

I could never comprehend how a small research team was going to do a 400 participant Phase 2 trial. That is a huge effort. Speculation either...

It was 400. They reduced it in today's update to 100. Hopefully that is a positive sign.

I've digested every word from Xenon Pharmaceuticals in these last four months. Bottom line is that they are absolutely thrilled with the efficacy...

With 100 participants as opposed to the previously mentioned 400 participants, that is good news as it will take less time to sift through the...

How the hell do I overestimate my own knowledge on the subject when I am chasing the only person/team in the world that can give us some...

Finally... What if the answer is the compounds are nearly identical? Then why not collaborate with Xenon Pharmaceuticals (if they are interested)...