AMPK — an Ion Channel Regulator

Discussion in 'Alternative Treatments and Research' started by Stephen Hill, Nov 18, 2015.

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    1. Stephen Hill
      Chatty

      Stephen Hill Member Benefactor

      Location:
      London
      Tinnitus Since:
      December 2014
      Cause of Tinnitus:
      Noise exposure
      Hey,

      I'm new to this, in fact this is my first post. I've been reading through the many excellent posts on here for a couple of months now as I come to terms with the T. Some brilliant stuff, keep it up guys!

      I've also been doing some digging of my own, and I came across this product from Life Extension, AMPK Activator http://www.lifeextension.com/vitamins-supplements/item01907/ampk-activator. Has anyone tried this? There seems to be some sound science to suggest it has an effect on the auditory system:

      This study seems to suggest that AMPK can help prevent hearing loss http://www.sciencedaily.com/releases/2012/07/120706164338.htm

      While this study looks at AMPK's effect on ion channels (which I understand is where T research is heading, and with some promising results from Retigabine it seems!) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502212/

      This article however, posted the other day on this forum, suggests that AMPK may have a negative effect on hereditary hearing loss http://news.yale.edu/2015/11/06/res...ification-may-prevent-hereditary-hearing-loss

      So, a mixed picture. Given it's role in regulating rather than opening ion channels, I wonder if it's effect might be more akin to Keppra than Retigabine, and therefore help with reactive T / hyperacusis rather than generally reducing T volume? Also it's more of a supplement than a drug, so would likely take a month or two to have any effect. It may be useless. But it does seem from the research that AMPK has an effect on the auditory system. And we have a product which is essentially off the shelf, with pretty much no other side effects (it's sold as being generally good for health, helping to repair damage to cells in a similar way to a low calorie diet). I've bought some to give it a go, but wanted to check if anyone else had tried it before I do?

      On a separate note, if anyone could advise me on what they consider to be 'safe' levels of noise (anything under 85db right - including moderate-volume restaurants, etc, should be OK right?), that would be much appreciated! I'm still trying to work out when I need to wear the earplugs...

      Also is it normal for T to react to the TV? Mine seems to about 50% of the time (I may have to bite the bullet for I'm a Celebrity... (trashy I know, but can't help myself!). Does reactive T tend to settle down in time?

      Thanks guys! :)
       
    2. noisebox
      Loved

      noisebox Member

      Location:
      Yorkshire, UK
      Tinnitus Since:
      04/2012
      Cause of Tinnitus:
      West End show. Came back 2015 vitamin D overdose prescribed
      I confused about the supplement here. I will try anything that can be found in healthy food rather than take a supplement where I don't know what's in it.
      I will say yes reactive T can settle down, mine did from T onset of 2012 to brilliant level T. Yes it can react to TV mine did for longer than any other sound.
      Sadly I have also found that a stressful life event or illness can set it all right back to square one. Which happened to me this year. I'm months in to reactive T and H again. Not very pleased.
       
    3. attheedgeofscience
      Uninvolved

      attheedgeofscience Member Hall of Fame

      Location:
      Denmark
      Tinnitus Since:
      Childhood
      Cause of Tinnitus:
      Head Injury
      Not uncommon.
       
    4. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      All this is, is immortality tea. I've been drinking this and taking the capsules for a long time and has made no difference. Great for your health though!

      https://www.tinnitustalk.com/threads/immortality-tea-jiaogulan.10469/

      Here's a study about it-

      http://onlinelibrary.wiley.com/stor...60&s=fc183cefdf4e4cbcede8d29e2517d766e04ed37b
       
    5. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice.
      Takikawa M1, Inoue S, Horio F, Tsuda T.
      Author information

      Abstract
      Blueberries or bilberries contain large amounts of anthocyanins, making them one of the richest sources of dietary anthocyanin. These berries are widely consumed as fresh and dried fruits, jams, or juices. Considerable attention has been focused on the health benefits of bilberry fruits beyond their antioxidant content or their ability to improve vision. In this study, we tested the effect of dietary bilberry extract (BBE) on hyperglycemia and insulin sensitivity in type 2 diabetic mice. We found that dietary BBE ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase (AMPK). Dietary BBE significantly reduced the blood glucose concentration and enhanced insulin sensitivity. AMPK was activated in white adipose tissue (WAT), skeletal muscle, and the liver of diabetic mice fed BBE. This activation was accompanied by upregulation of glucose transporter 4 in WAT and skeletal muscle and suppression of glucose production and lipid content in the liver. At the same time, acetyl-CoA carboxylase was inactivated and PPARalpha, acyl-CoA oxidase, and carnitine palmitoyltransferase-1A were upregulated in the liver. These changes resulted in improved hyperglycemia and insulin sensitivity in type 2 diabetes. These findings provide a biochemical basis for the use of bilberry fruits and have important implications for the prevention and treatment of type 2 diabetes via activation of AMPK.

      http://www.ncbi.nlm.nih.gov/pubmed/20089785

      Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue.
      Ok E, Do GM, Lim Y, Park JE, Park YJ, Kwon O1.
      Author information

      Abstract
      BACKGROUND:
      The effect of pomegranate vinegar (PV) on adiposity was investigated in high-fat diet (HF)-induced obese rats.

      METHODS:
      The rats were divided into 5 groups and treated with HF with PV or acetic acid (0, 6.5 or 13% w/w) for 16 weeks. Statistical analyses were performed by the Statistical Analysis Systems package, version 9.2.

      RESULTS:
      Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptorγ (PPARγ) in adipose tissue; increases for PPARα and carnitinepalmitoyltransferase-1a (CPT-1a) and decrease for SREBP-1c in the liver. Concomitantly, PV reduced increases of body weight (p = 0.048), fat mass (p = 0.033), hepatic triglycerides (p = 0.005), and plasma triglycerides (p = 0.001).

      CONCLUSIONS:
      These results suggest that PV attenuates adiposity through the coordinated control of AMPK, which leads to promotion of lipolysis in adipose tissue and stimulation of fatty acid oxidation in the liver.

      http://www.ncbi.nlm.nih.gov/pubmed/24180378

      Exercise, which is perhaps the most extreme metabolic stress experienced by normal humans, leads to activation of AMPK in skeletal muscle [21;46;218] and, at least in rodents in intraabdominal adipose tissue, liver [24;141] and probably other organs (J.Cacicedo, M-S. Gauthier, N.Ruderman, unpublished observations). It also has effects on insulin sensitivity [121;156;157] and gene and protein expression in various tissues [67;141;144;206], and in humans it reduces overall morbidity and mortality in an otherwise sedentary population [11]. In contrast, physical inactivity is known to be a powerful risk factor for many diseases and is beginning to be considered as a disease by itself [110]. It can be hypothesized that many of the beneficial effects of exercise and the adverse effects of physical inactivity are related, respectively, to the activation or lack of activation of AMPK. From a biochemical perspective, exercise can be used both as a model to study the mechanisms by which AMPK is activated in skeletal muscle and other tissues and as a tool to unravel its physiological roles in vivo. In this review, we will examine these possibilities, with special emphasis on the apparent ability of exercise to prevent and treat various diseases.

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779044/


      And-

      Grapefruits
      Persimmons
      Cayenne pepper
      Green tea, when brewed cold overnight
      Caffeine
      Rose hips
       
      • Informative Informative x 1
    6. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      Interesting that pomegranate's cardiovascular effects might be from this mechanism -- I've been having some daily for a while because of some research that showed it could have a beneficial effect on arterial plaque...
       
    7. Stephen Hill
      Chatty

      Stephen Hill Member Benefactor

      Location:
      London
      Tinnitus Since:
      December 2014
      Cause of Tinnitus:
      Noise exposure
      Thanks very much for your replies - most helpful. I guess I'll give AMPK a go for general health, rather than any expectation it will help with the T. Otherwise just magnesium/zinc/NAC, and a bit of time I suspect! And hope that the slight reactive element will chill out over the coming months. Btw, @Danny Boy and @attheedgeofscience thanks for all your pioneering work investigating research and trialling treatments, really impressive! I'm confident we'll have something to dampen this down in the next 5-10 years...
       
      • Like Like x 1
    8. Codaz

      Codaz Member

      I'm trying now some pomegranate pills (supplement) and see if it does anything. What wonders me is that they are sold out quite fast. They are quite stinky but I hope they do something.
       

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