Autifony's CLARITY-1 (Age-Related Hearing Loss) Phase II Study for AUT00063

Discussion in 'Research News' started by earsnothappy, Oct 15, 2015.

tinnitus forum
    1. earsnothappy

      earsnothappy Member

      Tinnitus Since:
      May 2014
      Has anyone heard any news from any patients that participated or are participating in the CLARITY-1 Trial?

      I would be curious to know if any of the trial participants have tinnitus and if they had any reduction. Or is tinnitus something that would have disqualified people from participating?

      Please don't turn this thread into a mess like the pinned AUT00063 thread.

      Thank you!

      http://www.autifonytherapeutics.com/autifony-age-related-hearing-loss-clinical-trial-faq.asp
       
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    2. Yo-Han

      Yo-Han Member

      Location:
      Belgium
      Tinnitus Since:
      2011
      For your information

      https://clinicaltrials.gov/ct2/show/study/NCT02345031

      phase1= pre clinical= still no results (expected december 2015, see tab study results)

      phase 2= recruiting stage, so looks like a go next year

      In other words, hardly any human tested on subject yet.
       
    3. derpytia
      Pooptoast

      derpytia Member

      Location:
      Rescue, California
      Tinnitus Since:
      04/2014
      Cause of Tinnitus:
      Hearing loss / ETD
      Is there a reason why they just go right on ahead with Phase 2 without posting the results for Phase 1? It seems almost so 'cloak and dagger' cept without the dagger.

      If Yo-Han is right, then I see a recurring problem.
       
    4. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      Any news at all on trial done in USA?
      No participants that reported yet?
       
    5. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      • Winner Winner x 1
    6. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      We should have this autifony compound made in China and given to all of us to try since it's safer than RTG!
       
    7. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Impossible since nobody knows its chemical structure.
       
    8. valeri

      valeri Member Benefactor Team Awareness

      Location:
      Australia
      Tinnitus Since:
      09/2011
      Aren't they supposed to release it eventually after some phase is done?
       
    9. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Where did you hear that?
       
    10. Onnie
      No Mood

      Onnie Member

      Location:
      Netherlands
      Tinnitus Since:
      10/2009
      Cause of Tinnitus:
      '09/1.0: Loud concert '15/2.0: Cause unsure
      I was at a TRT centre today. On the coffeetable I found a magazine about hearing disorders. I read an article about the research that is going on at the moment. They mentioned AUT00063 and I read something that I found quite interesting.

      They wrote that AUT00063 targets the kv3.1 channels because these channels become less active as people age. I found this quite interesting because a couple of times the question was raised why Autifony targets the kv3.1 channels and not the kv7 channels. Anyway, I don't think I read this anywhere else on the forum so I thought I'd share. Unfortunatly I cannot present a source, I forgot the name of the magazine and it was not a scientific article anyway.
       
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    11. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Excuse me Im mixed up here isnt Autifony00063 no more? Or is it still in trial?
       
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    12. Onnie
      No Mood

      Onnie Member

      Location:
      Netherlands
      Tinnitus Since:
      10/2009
      Cause of Tinnitus:
      '09/1.0: Loud concert '15/2.0: Cause unsure
      It's still being trialled for age related hearing loss. (only at sites in US)
       
    13. earsnothappy

      earsnothappy Member

      Tinnitus Since:
      May 2014
      It would be interesting to see if it passes the trial and makes it to market. Once it's on the market, it shouldn't' be too difficult to get.
       
    14. earsnothappy

      earsnothappy Member

      Tinnitus Since:
      May 2014
      Anyone know when the data of this trial will be released? Looks like Phase II was completed June 2016.
       
    15. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      Yes it was discussed and dissected on the Autifony thread - Kv7 is more of Trobalt action mechanism....but since Aut00063 was scrapped, the research has come to a complete halt. There is no point to discuss these Kv3.1 channels anymore....There is nothing even on the horizon in terms of a drug to relieve tinnitus.
      TRT is the best humanity can do for us.
      I think there is only ONE tinnitus researcher who is capable to come up with some form of pill for tinnitus, and that's Prof.Tsounouopopoloususees.....sorry I dont know to spell his name. But he only in pre pre pre preliminary stage of research lol
       
      • Agree Agree x 2
    16. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      I would not hold my hopes up for Clarity 1 - it is just like the last convulsions before death as the company goes bankrupt.
       
    17. Penate

      Penate Member

      Tinnitus Since:
      07/04/2015
      Yes dan I'm 100% agree with you, people going to start living in the moon 10 or 20 years by now and tinnitus and hyperacusiss NOTHING.TRT, hearing aids, and CBT.
       
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    18. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      I think the clarity 1 trial was a flop
       
    19. MikeP505
      Curious

      MikeP505 Member Benefactor

      Location:
      Ontario Canada
      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Punishment for being so darn good looking!
      Na. We decided against living on a useless moon and are now planning on Mars as a long term living area. This will only cost multi billions of dollars!! We do like to spend tons of money on new frontiers but tinnitus??? Na. It doesn't get spread around like some disease . Save the money for throw away rocket engines.................
       
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    20. Ian Mac

      Ian Mac Member

      Tinnitus Since:
      2011
      Cause of Tinnitus:
      Vestibular Nueritis, loud music (dubstep)
      You don't have tinnitus you have either pulsatile throbbing, ear bone spasms, damage from loud music, cochlear hydrops, or cervical spine damage. You need to go into your brain and figure out what caused your noises and make peace with the underlying reason, then stop that underlying cause. But if you just go "hey fix my tinnitus" there's no chance because only you know your history .
       
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    21. Markku
      Inspired

      Markku Director Staff Benefactor Hall of Fame Team Trobalt Team Tech Team Awareness Team Research

      Tinnitus Since:
      04/2010
      Cause of Tinnitus:
      Syringing
      It indeed was not successful, thanks @DebInAustralia for checking it out further.

      Below is a snippet from Autifony's staff:

      Attached is the news release about our trial results. Unfortunately our drug, AUT00063, did not show a beneficial effect on age related hearing loss, although it was safe and well tolerated.

      Clearly these results were disappointing, and we are continuing to analyse the data in detail. We will publish more about our findings in due course, as this is the first time that a pharmaceutical has been tested in such a clinical trial for age related hearing loss, we learned a great deal from carrying out this study and hope that some of it can be useful for future research in this field.
       

      Attached Files:

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    22. Kane Moffat
      Badass

      Kane Moffat Member

      Location:
      Glasgow, Scotland
      Tinnitus Since:
      06/2015
      That's dissapointing. How did this study differ from the quiet-1 study? Was it the same compound used?
       
    23. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Same compound
       

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