Effects of C-phycocyanin and Spirulina on Salicylate-Induced Tinnitus

Discussion in 'Alternative Treatments and Research' started by calin, Apr 6, 2013.

tinnitus forum
    1. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058215

      Abstract
      Effects of C-phycocyanin (C-PC), the active component of Spirulina platensis water extract on the expressions of N-methyl D-aspartate receptor subunit 2B (NR2B), tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and cyclooxygenase type 2 (COX-2) genes in the cochlea and inferior colliculus (IC) of mice were evaluated after tinnitus was induced by intraperitoneal injection of salicylate. The results showed that 4-day salicylate treatment (unlike 4-day saline treatment) caused a significant increase in NR2B, TNF-α, and IL-1β mRNAs expression in the cochlea and IC. On the other hand, dietary supplementation with C-PC or Spirulina platensis water extract significantly reduced the salicylate-induced tinnitus and down-regulated the mRNAs expression of NR2B, TNF-α, IL-1β mRNAs, and COX-2 genes in the cochlea and IC of mice. The changes of protein expression levels were generally correlated with those of mRNAs expression levels in the IC for above genes.


      Although some medications appeared to be effective for tinnitus, the results were still not so satisfactory and/or their adverse side effects prevent them as a regular treatment for mice and/or humans [7][9]. Therefore, it is still worth searching for more “safe and effective” medications for tinnitus.
      Spirulina is a microscopic blue-green algae living both in sea and fresh water. It is composed of high quality protein, iron, gamma-linolenic fatty acid, carotenoids, vitamins B1 and B2, minerals, and its active component: C-phycocyanin(C-PC), etc [10]. It has been reported that Spirulina platensis water extract or C-PC exerts anti-oxidative, anti-inflammatory activities and neuroprotective effects via inhibition of COX [11] and/or nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzymes [12]. Meanwhile, as we mentioned above, tinnitus were associated with up-regulation of the NR2B and proinflammatory genes [5], [6]. So, Spirulina might be also a good candidate for prevention or treatment of tinnitus.
      In this study, we aim to investigated whether C-PC or spirulina platensis water extract could reduce the tinnitus score and expression levels of NR2B, TNF-α, IL-1β, and COX-2 genes in the cochlea and IC in response to intraperitoneal injections of salicylate.

      Results
      This experimental study showed that the both of spirulina platensis water extract and its active component (C-PC) could reduce salicylate-induced tinnitus and reduce expression of NR2B,....

      ..... In conclusion, we suggested that spirulina platensis water extract and its active component (C-PC) could reduce salicylate-induced tinnitus. The beneficial role of spirulina mainly via inhibiting expression of NR, COX-2 and proinflammatory genes.
       
      • Like Like x 1
    2. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      More excellent information! It looks like they are referring to tinnitus that is caused by some sort of inflammation--- which could be most types of tinnitus.
       
    3. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      I take organic green super food twice a day. Just looked on the container... it has organic spirulina as an ingredient. I wonder how much one should take of spirulina to have the positive effects indicated in the study/research experiment.
       
    4. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      I will do more research on this when I have some free time at work.

      I know you love natural... I am working on it!!! :LOL:
       
    5. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      I found this link, that has a list of foods containing salicylates. There are a lot of foods that are extremely high in salicylates that are very common:

      http://www.gfcfdiet.com/SalicylatesGFCFfood.htm

      However, some people are more sensitive to the effects of salicylates than others. I don't want to have to give up strawberries, just because they're on this list!! Maybe the spirulina can counteract that.(?)
       
      • Like Like x 1
    6. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Do you use super greens daily Karen?

      I will test it on strawberries today. I had a bunch the other day and didn't notice anything. I will pay attention this time.

      Here is another published article on spirulina: http://www.cyanotech.com/pdfs/spirulina/sptl28.pdf

      I hope to weed through it today... a lot to read through!
       
      • Like Like x 1
    7. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      No, I don't use super greens. However, it looks like it may be a good idea to try something containing spirulina, based on your posts.
       
    8. jazz
      No Mood

      jazz Member Benefactor

      Location:
      US
      Tinnitus Since:
      8/2012
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD
      Thanks calin!

      Tough reading indeed! But at least there's no quiz afterwards. :p And it's good to read the actual scienitific monographs.

      I've used several "super green" formulations. Typically, I'll mix them with yogurt for a smoothie. Think I'll head out to the vitamin shop today and look specifically for spirulina!! :)

      Here's another article on it:

      http://www.umm.edu/altmed/articles/spirulina-000327.htm
       
    9. jazz
      No Mood

      jazz Member Benefactor

      Location:
      US
      Tinnitus Since:
      8/2012
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD

      Karen,

      Thanks for the link! Yesterday, I had a nasty spike, and I think it was from a flavored cheese (sun-dried tomato). The packaged specifically listed "salicylates" as an ingredient. Of course, I only noticed this after I had a piece. I thought it might be okay as I only had a half ounce, but it was not!

      I'm thinking it was the sun-dried tomatoes, not the cheese. I"ll look it up, but I do love sun-dried tomatoes. Perhaps, this will be another thing I'll have to make myself. Tinnitus has forced me to abandon most prepared foods. And, though I love cooking and eating organic, I really don't want to manufacture everything I eat! :D
       
    10. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Jazz,

      It sounds like you are correct; it seems likely it was the sun-dried tomatoes. What a shame that we have to give up so many foods because of tinnitus! I hope your tinnitus spike has settled down now.

      I've never tried spirulina or any of the super-greens formulas. Do you have to ease into taking them? Are they hard on the digestive system? I thought I had read about that somewhere. I may try it to see how well it works for tinnitus.
       
    11. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Karen, I take 2 servings of this product daily. One in the morning and one in the evening with my supplements and teas.

      You can always start out with just one serving and then increase as you feel necessary. https://www.swansonvitamins.com/amazing-grass-green-superfood-orange-dreamsicle-8-5-oz-pwdr

      I also can get the regular flavor from my local Fresh and Easy Market.

      Maybe you can get just spirulina. Ah ha - just checked - yes. https://www.swansonvitamins.com/swa...s-certified-organic-spirulina-500-mg-180-tabs
       
    12. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Thanks, Calin! I just ordered the plain spirulina from Swanson's. I'll try that first. It's certainly worth a try!
       
    13. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Great! It is a reasonable price too!

      Keep us posted about it.
       
    14. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Just received my order of spirulina and took the first tablet. I'll let you know how it works for me.
       
    15. jazz
      No Mood

      jazz Member Benefactor

      Location:
      US
      Tinnitus Since:
      8/2012
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD
      Yes, let us know. It might take a few weeks to reduce your T. If you are thinking about other supplements, you might try one at a time. Just a thought. It's easier to keep track of what's working/not working. :)
       
    16. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      I certainly will. I've already tried several supplements, that, for me, have not worked to reduce my tinnitus. The ones I've tried include: Vinpocetine, gingko biloba, GingkGold, pharmaGaba, systemic enzymes, and moringa oliefera.

      I agree; it's best to try out one new supplement at a time.
       
    17. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      I've just begun taking the Swanson's Green Foods Spirulina; the first 2 days, I took only 1 tablet. Now, I'm up to 2 tablets per day. I have had a good tinnitus day today; it's too early to tell, but the Spirulina may be working for me.
       
    18. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Yay for good tinnitus days!!!!
       
    19. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      So Karen, you are now taking 1 gram of spirulina. Yes?

      I can't tell how much I am getting in the super green food I am taking. It shows 5392 mg of a combo - wheat grass, barley grass, alfalfa, spirulina, spinach, chlorella and broccoli.
       
    20. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      Hi, Calin,
      Yes, I am now taking 1 gram of spirulina. I'd be interested to know how much of the spirulina is in your Super Greens. I'm glad it continues to work well for you!
       
    21. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
      Well... I am not really sure what it is that is working. I am doing soooo much! haha

      How is the pulsing? Is it changing as the T?
       
    22. Karen
      Talkative

      Karen Manager Staff Benefactor Hall of Fame Ambassador

      Location:
      U.S.
      Tinnitus Since:
      05/2010
      Cause of Tinnitus:
      First time: Noise 2nd Time: Ototoxic drug
      It's hard to tell, but the pulsing seems to be a little bit better. I'll keep you posted on my progress!
       
    23. stickywicket

      stickywicket Member

      Location:
      Florida
      Tinnitus Since:
      2009
      Has any one tried a salicylate free diet for 4-6 weeks to see if there was a significant reduction in tinnitus? Aside from the medications, many foods are high in salicylates (spinach is high in salicylates) , and personal health care products such as toothpaste. My family has over the top reactions to foods or food additives after long term exposure. For example, my mother is doubled over sick for days if she eats carageenan. I have taken asprin and ibuprofen my entire life, and now both of those products make my tinnitus 3x as loud. Around the time of my dental work, I was taking lots of ibuprofen (combined with antibiotics), and maybe the buildup of salicylates in my system has made me sensitive to salicylates in foods too.
      There are three categories of NSAIDs: salicylates, traditional NSAIDs, and COX-2 selective NSAIDs.

      There are acetylated salicylates and non-acetylated salicylates. Aspirin is the best known acetylated salicylate, also called acetylsalicylic acid. Non-acetylated salicylates include choline and magnesium salicylates.

      http://osteoarthritis.about.com/od/osteoarthritismedications/a/nsaids.htm

      http://fedup.com.au/factsheets/additive-and-natural-chemical-factsheets/salicylates

      How many people are salicylate intolerant and don't realise it?
      Research shows that about 20% of adults with asthma1, 60% with of people with food-induced itchy rashes, headaches or migraines, 70% of people with irritable bowel symptoms2 and 75% of children with behaviour problems3 may be sensitive to salicylates. In my experience, most people with salicylate intolerance have no idea what could be affecting them.
      High levels of salicylates are found in foods considered very good for you - does that surprise people?
      Most people think fruit and vegetables are so healthy, you couldn't possibly eat too much of them.
      One woman wrote: "From a cancer prevention perspective I am encouraged to eat a diet high in antioxidants (fruit and vege colours of the rainbow). How can I ensure I am getting the correct nutrition eliminating salicylates?"
      "It's a myth that fruit is packed full of vitamins and minerals," says Tom Sanders, who is director of the Nutritional Sciences Division at King's College London. "... The really sad thing is that we don't eat enough vegetables, such as cabbage...' 4.
      Salicylate sensitive people often think they should eat 'healthy' salicylate-containing foods despite unwanted side effects but this is wrong. Inflammation is increasingly regarded as a contributor to cancer and other diseases. If 'healthy' foods make you ill, they are not healthy for you. Of the top five foods found to be most effective in inhibiting growth of cancer cells, the top four are low in salicylates (Brussels sprouts, cabbage, garlic and shallots or scallions)5.

      and one more good link,

      http://www.ifood.tv/blog/top-10-food-contianing-salicylates
       
    24. calin
      Inspired

      calin Member Benefactor

      Tinnitus Since:
      Oct 2011
    25. stickywicket

      stickywicket Member

      Location:
      Florida
      Tinnitus Since:
      2009
      I currently cannot take ANY asprin, ibuprofen, etc without having my ears ring twice as loud. My diet of mostly fruit and veggies contains tons of naturally occurring salicylates from food. There are high amounts in tea, and in fruit etc. So the healthier I have been trying to eat, the more salicylates I ingest. And a few months back I started using avocado oil as a moisturizer, and slathered that on myself after showers. So, my sensodyne toothpaste, my peppermint mouthwash, my shampoo, my avocodo oil moisturizer, and all of the fruits and veggies I ate are high in salicylates.. which is a substance to which I've developed an intolerance! OK, it is just a theory, but I stopped eating / using anything with salicylates on Monday, and already the ringing has gone down some! http://failsafediet.wordpress.com/the-rpah-elimination-diet-failsafe/
       
    26. click
      Busy

      click Member Benefactor

      Location:
      West Cornwall, England, UK
      Tinnitus Since:
      06/04/2012
      Cause of Tinnitus:
      Not sure

      very interesting sticky! Ilooked at this a few months back but didn't follow it through.. I'll check the foods I eat...
       
    27. click
      Busy

      click Member Benefactor

      Location:
      West Cornwall, England, UK
      Tinnitus Since:
      06/04/2012
      Cause of Tinnitus:
      Not sure
      The

      The main reason that I find this issue interesting is that tea is incredibly high in salicylates and tea makes my T go through the roof.

      I'm going to give it a go for 1 week. I won't be able to cut them out completely but I'll aim for 95% ish... will let you know what happens!

      Click
       
    28. stickywicket

      stickywicket Member

      Location:
      Florida
      Tinnitus Since:
      2009
      Hi Click, How did it go with the salicylate free week? I just reread one of your previous posts, and many of the foods you listed such as celery, brussel sporuts are on the no salicylate food list. Back in May I tried the salicylate free diet and had results and over the last few months I went astray. My T was crazy bad, and I re-examined my diet and again cut out the high amounts of salicylate. And the T has again gone down quite a bit. I'd be interested to know if you saw any change? Thank you.

      Here is a link to the Salicylate forum http://salicylatesensitivity.com/forum/comments.php?DiscussionID=148&page=1#Item_0
       

Share This Page

Loading...
If you have ringing ears then you've come to the right place. We are a friendly tinnitus support board, dedicated to helping you discuss and understand what tinnitus treatments may work for you.