Epileptic Drugs and Tinnitus

Discussion in 'Support' started by JasonP, Sep 15, 2016.

tinnitus forum
    1. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      Interestingly enough, in the treatment section I see quite a few drugs (anticonvulsants) that can be used for epilepsy which may help some (not all) with tinnitus:

      Trobalt
      Carbamazepine
      Neurontin
      Pregabalin
      Topamax

      Not recommended long term:

      Barbiturates
      Benzodiazepines

      I have read other accounts here where some other anticonvulsant drugs have helped people with tinnitus. I figured I would share this video to see if we could figure out if we could learn something and maybe come up with an idea or two on how this works. To give you a little background the guy talks about hyperpolarization and depolariazation. It has to do with electrical charges. Here is a graph from Wikipedia:

      1221_Action_Potential.jpg


      The video is below. I am not a scientist so I cannot verify if all of the following is true but I find it interesting. Do you think this could shed light on how some of these drugs may help with tinnitus?


      Epilepsy pharmacology - Soton Brain Hub


      By the way, I know tinnitus is very complex, but I wonder if this could shed just a little light on things.
       
    2. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      I think it's pretty interesting. A neurologist I've seen likes to say I have "status tinnitus", a comparison to "status epilepsy" where people have constant seizures.

      When epilepsy drugs work for people's tinnitus, it seems like we have to conclude that the drug is somehow slowing down or stopping some kind of hyperactivity. For me, benzos definitely do that, but other seizure drugs I've tried like Trileptal, did not have that effect. But, they clearly work for some people -- there was some amount of research that led me to try Trileptal in the first place.
       
    3. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      I read online where the resting potential of a neuron is -70mv. I wonder in some people if certain neurons are overactive and more positive
      The video above mentions the AMPA receptors. I found this...kind of interesting. Maybe you could ask your neurologist about it:

      https://google.com/patents/WO2005049042A1?cl=en
       
    4. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      that's pretty interesting and I could try, but, I wouldn't expect much. He's really good about letting me try weird drugs if I have an evidence based reason for wanting to do so, and he's also really good at waxing intellectual about life in a very wordy and slow way in a clear effort to impress the uniformly attractive, young, female med students that he has as fellows... but pretty short on actionable insight, AFAIK ;D
       
    5. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      The only prescription drug I could find that worked on AMPA receptors was Perampanel and I am not sure if it is worth trying because of the possible side effects. Plus it isn't generic so it is rather expensive if you don't have insurance.
       
    6. grate_biff
      No Mood

      grate_biff Member

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      aucustic trauma, benzo withdrawl or both
      @JasonP Maybe you find this map over different anti-epileptics and their targets interesting:)
      Skjermbilde 2016-09-16 kl. 18.06.41.png
       
      • Informative Informative x 2
      • Helpful Helpful x 1
    7. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      yeah, I think I personally am past the point of trying any drugs unless they have well established, not-scary side effects lists.

      I'm gonna take a run at low-dose naltrexone because I'm curious to see what impact it has on my other health issues as well as tinnitus, but the side effects of a tiny 3mg of naltrex are nothing compared to nearly any of the psych meds out there.

      When I was a lot more unhappy and desperate, I was more willing to eat stuff like Trobalt.
       
    8. Alue

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      Good video. Although I was a little disappointed he didn't cover potassium ion channels.

      Here is a good overview: www.medscape.org/viewarticle/570744_3
       

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