Lenire — Bimodal Stimulation Treatment by Neuromod

I highly doubt that Neuromod would sink millions of dollars of investors' money into a bunch of fake studies to sell a device that will not work. People develop tinnitus every single day unfortunately. The market for this device is ever growing. Yes they stand to make a lot of money off of current sufferers, but if it was found to be a complete sham that would mean the end of their profits. I don't think that's what their plan is.

As of right now this treatment is ground-breaking. Some skepticism is healthy, but to suggest that they are making it all up is a bit far fetched in my opinion.

 

I hope it works, but just want to say that their claims should taken with a healthy dose of scepticism - especially when the trial is unregulated.
As far as honesty among medical and farmaceutical companies, just do a google search. It is not that good in some cases.
I think there will be a cure eventually, perhaps this time or maybe not this time - who knows.

 

The hiring of Dr. Lim lends Neuromod credibility. As someone from academia he sounds legit and not someone who just would deliberately attach his name to a sham. I think there is sincerity there but that might not be true of every stakeholder behind this who may be looking for a ROI.

The nature of tinnitus treatments not working means anything that even offers scattershot results is going to be welcomed with open arms. It would just be best if they scaled the price accordingly. But waiting for something that is more deterministic and more dramatic might mean having us wait for years more. Perfect is the enemy of good.

 

From what I can gather they pulled MuteButton from the market because of questions about its efficacy. For me that lends a greater amount of credibility. It wasn't just about making a quick buck, then disappearing.

 

There's not just Lim, there's Deborah Hall too... she's fairly prominent in the UK I believe.

 

Still no news I suppose?

 

Someone suggested there would be news at the end of June, right? I guess we will not have news until that day :S

 

I think you need to learn what clinically significant means before you go bashing it. It means that a result can reliably be attributed to a treatment, given all other factors. It's not an adjective, it's a noun, and not really up for debate.

 

Exciting times hopefully...

 

I can´t wait to read reviews from people who have severe tinnitus and who are real users of this forum.

 

With a 66% clinically significant response rate it won’t help everyone that much.

80% was for an improvement but that was measured as even less than 10 points on THI?

 

I have relatively mild tinnitus and intermittent hyperacusis and ear spasms. If it can cut my tinnitus down, that would be one hurdle overcome.

 

@kelpiemsp I’ve read a few of your posts on this treatment modality. Has the improvement been long term for you?

 

Are you familiar with the word GREED? Defective useless products are sold everyday.
Hundreds of veterans are filing lawsuits against a government contractor that manufactured and sold defective combat earplugs to the military.

The earplugs didn’t maintain a tight seal and allowed dangerously loud sounds to slip through without the wearer knowing.

The lawsuits allege that Minnesota-based 3M Company designed the earplugs in a defective manner and failed to warn users of the defect or to provide proper instructions for their use, according to a copy of one lawsuit provided to Military Times.

The failure allegedly resulted in hearing loss, tinnitus and loss of balance in those who used 3M’s trademarked, dual-ended Combat Arms earplugs during their military service between 2003 and 2015.

 

Yes. Life is good! Thanks for asking.

 

@kelpiemsp no worries! That’s amazing. Was your tinnitus quite mild to start with? Mine's relatively mild so hoping Lenire can knock it out.

 

Hi Don Tinny,

I belong to the 0.1% extremely severe tinnitus sufferers. Can't wait for the release of Lenire but on the other hand I am quite skeptical of it helping me. I have tried almost every treatment in the past except for Deep Brain Stimulation.

I will make the purchase decision once the price is unveiled.

Maybe I will also wait for feedback from other members here before I buy it. I don't know yet.

Nobody can predict if it works - it's so unfair.

Does anybody know if any medication might inhibit the treatment's effect?
I take a lot of medications, believe me.

 

It’s related to a predetermined percentage of improvement of which a patient would require to notice or see an important in their symptoms. However it's not always exactly clear what the level of improvement required is deemed to be clinically significant especially with something such as tinnitus. Regardless, it’s not to be confused with statistical significance (related to the probability and robustness of the trial). I work in pharma sadly (yes my life is boring ha).

 

You went from severe tinnitus to mild... is that right @kelpiemsp?

 

I've wondered about this too. This device is supposed to work by encouraging neuroplasticity within the brain. I've read in a few places that some people think that ADs may inhibit neuroplasticity. I can't seem to find any researched evidence that it does or doesn't though.

I even emailed Hubert Lim back in December asking this very question. He sent me a long thoughtful response that didn't really answer the question. He advised me to try other avenues before taking meds.

I don't want to get into a situation where the meds are potentially inhibiting the device. At this point it's really the only thing keeping me off the meds.

 

Are you sure they don’t mean statistical significance!? I work as a Cancer Research scientist and we never use vague adjectives like “significant” unless it’s predefined by the measure of statistical validity. I haven’t followed their research outputs recently, however.

 

So that brings it back to the bit in their study paper defining 'clinical significance' in this trial as being a reduction of 7 points or more on a patient's THI score - doesn't it?

 

No. Clinically significance is likely the score required in order to prove the treatment has worked. They are likely taking into account fluctuations in THI + what it takes to for P to be < .5. So no... it doesn't.

 

Yup. My THI was routinely in the 80s with an MML at 85 dB.

 

That's a really good question! I wonder how nobody, including myself thought of asking this.

I am on ADs myself...

 

What are your THI and MML now after treatment?

 

If you were treated again is it possible to see even more improvements?

 

Significantly less lol

 

Wow that’s a huge change. When do you think Minnesota will have a device on the market?

Now your MML is what, 20 dB?

 

Neuromod liked this twitter post

“Welcoming @RichardbrutonTD to #TheDigitalHub this evening for the #FutureCreators Graduation & Showcase of work. The Minister will also meet @mobilitymojo & @NeuromodDevices who are both based on our campus.“