N-Acetylcysteine (NAC)

Hi,

I came across this on a music forum discussing tinnitus and on further searching, it seems that a lot of people are getting benefit from it.

Just wondering has anyone here tried it.

Think I'm going to go order some anyway as it's supposed to protect inner ear and possibly might benefit tinnitus.

Cheers

 

Thanks for that on melatonin Markku! I take a wee bit of liquid melatonin every night.

 

Ok cheers for that. I would take it for the protection also and if it helps in other ways then all good. Solgar do it also and i think they're supposed to be best for vitamins. Going to hit the health shop later. Do you take vit c also with them Markku?

 

tweak...very interesting stuff indeed, seems to help more with prevention that curative way after the tinnitus has been going on for a while...but none the less...

i think the us navy uses n acetylcysteine to inhibit hearing loss... administered quickly after extreme noise exposure

for example a member of a deck crew on aircraft carrier sometimes has protective head gear knocked off as a jet engine is throttling up and if given large doses of NAC and another supplement ( L- carnitine?) immediately after noise exposure allegedly limits oxidative stress and damage to the hearing hair cells (stereo cilia)

http://floridadetox.com/hearing-los...d-by-n-acetyl-cysteine-and-acetyl-l-carnitine

Markku

i think your information about the protective effects of melatonin against ototoxicity deserves its own thread so that people looking for this information are more likely to see it

btw aspirin (which can temporarily cause tinnitus symptoms) has also been found to be protective against the otoxicity and hearing loss often caused by taking aminoglycoside antibiotics if the aspirin is taken concomitant with the antibiotic

http://www.ncbi.nlm.nih.gov/pubmed/16844331

 

interesting article...lots of stuff you already know...BUT...for those who are asking how much NAC, when and how often to take it...heres an informed professional recommendation

-------------------

Hearing Loss Prevention: Loud Noises We Hear Daily​

http://www.huffingtonpost.com/2013/02/07/hearing-loss-loud-noises-noise-levels_n_2632499.html

Swallow Some Protection​

Inside our ears lie thousands of hairlike cells that turn sound waves into electrical signals so the brain can interpret what we hear. But very loud noise generates free radicals that damage those cells -- sometimes permanently. The U.S. military has been pouring money into research on prevention, and it's paying off. A clinical trial revealed that an over-the-counter supplement called N-acetylcysteine worked much better than earplugs alone at minimizing damage in Marines exposed to gunfire. Researcher Richard D. Kopke, MD, recommends taking 1,200 milligrams 12 hours before you're bombarded by loud noise (say, at a sporting event). If the noise is unexpected, pop 1,200 milligrams as soon as possible and take 900 to 1,200 milligrams three times a day, with meals, for the next 14 days.​

​

(i have to confess that is more than ive taken before, i was too cautious maybe!?)

best wishes
mt

 

I was taking NAC for over 20 years and then I got T last year so from my own experience it doesn't help. I have tried to take it since getting T and it makes my T worse. I used it to fight cancer and improve my immune system.

 

A case of T disappeared after taking NAC!

http://www.ajol.info/index.php/ajpsy/article/viewFile/91125/80563

 

Hey Markku, thanks so much for all of your effort and data on TT!! You have really helped me out! Question, any intel on whether any of these supplements (melatonin, NAC, etc...) have any clinical support for helping idiopathic tinnitus?? Appreciate any thoughts/info you might have on that. Thanks again!!

 

Clinical research on the effectiveness of supplements on tinnitus has been very mixed.

Having said that: I take them, including NAC. I do 600 mg daily, like Markku. I took a very large dose (1800 mg to start, then 1200 daily for the next two days), on the recommendation of my doctor immediately following a severe noise exposure and it did seem to help. But I would not take those levels on a regular basis.

I also take Rozerem, which is a prescription drug in the US. Its basically is pharmaceutical-grade melatonin. I take it for sleep and it has helped. Great thing about it is that it is not addicting and has few side effects.

 

N-acetylcysteine

http://www.actiononhearingloss.org.uk/community/forums/tinnitus.aspx?g=posts&t=4410

Looks interesting must be stuff on here about it ,anyone?


EDITED
wow look at this !!!

...and look at the Dose ,,,2 grams .....a lot more than the usual 600mg that is normally bandied about

http://www.ajol.info/index.php/ajpsy/article/viewFile/91125/80563

 

well whose going to try the three or four capsules a day?

 

I'm popping it like candy. 1600 mg or more a day. After a week, my H went away. Seems to be making a huge difference. The T seems to be heading south but still to early. In the early stages, I think this is a must have vitamin.

 

@JohnG

Last year, a psychiatry journal published a letter about NAC and tinnitus. The letter described a woman being treated with NAC for unipolar depression (2g, daily). As a pleasant and unexpected surprise, the NAC nearly eradicated her tinnitus; and, when it did reoccur, she described it as "much less noticeable" than before her treatment. Please note her tinnitus, which she described as "medium" but nonstop, had bothered her for six years prior to the NAC treatment.

Here's the link:

http://www.ajol.info/index.php/ajpsy/article/viewFile/91125/80563

Good luck!

 

Thanks jazz. I definitely have experienced an improvement when I started it. I take that + magnesium in high dosages. Will do so for about a month then go into maintenance doses. The US Navy has tested this and I think the results have shown that it will also protect against further noise induced damage and possible ototoxicity. So I think I will take this for the rest of my life or until hair cell regeneration works...which ever comes first.

 

Nice one john your a star. My problem is this ,what to do ,what to do?????/

http://articles.mercola.com/sites/a...plement-could-cause-you-loads-of-trouble.aspx

 

Before another Dentist visit i will take 1200 mg

 

Markku didnt see the mice were getting a human equiv of 20grams ,that makes it more palletable,,,and your 600mg have you ever cranked that up to 2 grams (maybe the theraputic dose)

 

This is nice and positive (not about t but other things)

http://www.healthy.net/scr/article.aspx?Id=575

 

I don't have any adverse affects other than a little gas, dryer mouth, and perhaps a bit more bowel movements. I will continue on this dose for at least a month. Then I might go to a maintenance dose of 500mg. I got my blood pressure/heart rate measured and it is just fine. I would suggest you get you bp/hr checked. But I am at 1.5g per day. If I go to 2g, I get a slight upset stomach which I don't like.

 

johng just ordered the stuff,well i would wouldnt i lol do you take it with food ,I know aminos should be on their own but stomach wise probably a better idea.

 

Carlover, my bottle of NAC says to take it with juice or water with a carbohydrate meal.

 

cheers adam .good luck pete

 

I'm just taking it with water. Sometimes with a meal. Either way, it gives me a little dry mouth when it hits me. Of course, I had no placebo to check this, but my H went completely away...and it was hell. I still have the T (high pitch hissing sound). But I can now listen to music...and apart from the overlay of hissing, the notes from a piano or saxophone sound normal now. That is a huge improvement for me!!!

 

Hi JohnG,
wow, that's really good news. I am still taking this "Hearing Pill" but without any effect until today.
I also still take CoQ10 and Magnesium, sometimes also VitaminB12, but until now, nothing
has really changed.

Greest tomytl

 

Hey Tomytl...yes, about two days ago, I noticed no distorted sounds. The T is still non stop hissing but sounds is not so bad to my ears. I've been taking the NAC for just over one week. I did order the Hearing Pill but it has pretty much the same stuff you and I are taking. But I got two bottles. The T seems to be the real difficulty now.

 

For your own safety, the higher amounts are probably best taken like Johno uses it- as preventable measure. I'm also taking it when the viruses are on the move, at colder period, boosts immune system. Cycle it. I feel that theres not enough research done on NAC, that its safe to take a round the year. Depends on ones age and physical condition as well. Older you get less glutathione and taurine your body produces.
It seems to have good effect on my H, at least my 8 month daughter screams hasn't set me back. Wierdly, i can't take than 600 mg per day, as it makes me really nauseous. 300mg is sweetspot to me. I'm sure its really acidic, so should not be taken with food. Maybe half an hour later or before. Nac depletes copper, so put some seeds in your diet. This is a great amino acid to have in your arsenal! Heavy artillery for sure for many occasions.

 

tomytl is this the hearing pill you are taking?