New, General Formula to Treat Brain Disorders, Tinnitus Included (2016)

Discussion in 'Research News' started by monacco, Jan 29, 2016.

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    1. monacco

      monacco Member

      Location:
      forte Antoine .monaco
      Tinnitus Since:
      29/09/2015
      Cause of Tinnitus:
      anknown
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    2. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      This I find an interesting approach to find new developments in fields we are interested in. Never thought about that.
      It was an interesting read!
      I wonder at what stage of the whole process a company want to secure a compound through patenting it.
      Is this at an early stage?
       
    3. Jahhsoul
      Curious

      Jahhsoul Member

      Location:
      Spain
      Tinnitus Since:
      9/24/2015
      Cause of Tinnitus:
      Unkown (not acute acoustic trauma).
      Good new! Can anyone download the PDF?
       
    4. Jahhsoul
      Curious

      Jahhsoul Member

      Location:
      Spain
      Tinnitus Since:
      9/24/2015
      Cause of Tinnitus:
      Unkown (not acute acoustic trauma).
      Dont registrate, the pdf only contains how to synthesize it ;)

      It would revert CHRONIC T
      ("Therefore, the object of the present invention was to identify compounds that modulate neurogenesis. It has been found that the compounds of formula I are active in this area and they may therefore be used for the treatment of .... Tinnitus....").

      And prevent it ("The present invention relates to compounds of formula I and to their pharmaceutically acceptable salts, to these compounds as pharmaceutically active substances, to the processes for their production, as well as to the use in the treatment or prevention of disorders, relating to neurogenesis, Tinnitus...").

      Wow if this drug is released we can make a great party at 120 db with nice music. It prevent it and revert the brain damage of MDMA and cocaine so it would be a nice night. :rockingbanana::rockingbanana::beeranimation:
       
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    5. Dutchy
      Not worthy

      Dutchy Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      12/2014
      Cause of Tinnitus:
      Neuronmodulation suggests noise induced?
      LOL
       
    6. Dutchy
      Not worthy

      Dutchy Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      12/2014
      Cause of Tinnitus:
      Neuronmodulation suggests noise induced?
      The sad thing about patents is you never know why they accumulate them.
       
      • Good Question Good Question x 1
    7. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      The word alone "neurogenesis". Wow!
       
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    8. exodus
      Cold

      exodus Member

      Tinnitus Since:
      05/2008
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    9. Ecip

      Ecip Member

      Location:
      Edmonton, AB
      Tinnitus Since:
      4.11.2015
      Cause of Tinnitus:
      Still unknown... possibly noise exposure?
      What this about now? I'm confused.
       
    10. Bertman
      No Mood

      Bertman Member Benefactor

      Location:
      canada
      Tinnitus Since:
      07/2015
      Cause of Tinnitus:
      concert
      seems like a wonder drug.. don't like being pessimistic but we might as well keep dreaming
       
    11. pebbles

      pebbles Member

      Tinnitus Since:
      march14
      does anyone understand this or translate it in simple terms
       
    12. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      If you look for neurogenesis on Wikipedia it gives you a short explanation what this drug should or could do.
      https://en.wikipedia.org/wiki/Neurogenesis
       
    13. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      It's a patent that covers a potential compound and a wide range of derivatives. They also claim it cures every ailment under the sun. Not much info on this,

      The only article I could find is this one : http://www.ncbi.nlm.nih.gov/pubmed/24998602

      Apparently it binds to a certain CDK5 catalytic site. That's all we know. No animals study, nothing medically relevant as of right now.
       
    14. Ecip

      Ecip Member

      Location:
      Edmonton, AB
      Tinnitus Since:
      4.11.2015
      Cause of Tinnitus:
      Still unknown... possibly noise exposure?
      If this really does cure everything, or in this case even some things, it'll never be marketed. Big pharma will make sure of that. Because a world in which people genuinely want to cure people and do good.. Well that would be crazy.
       
    15. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016

      Fuck Yeah!!! hahahahaha
       
    16. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      What do you mean?
       
    17. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      do you have an opinion on this... @Cityjohn
      lol sorry, but you have great insights
       
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    18. Cityjohn
      Studious

      Cityjohn Member Team Research

      Location:
      Amsterdam
      Tinnitus Since:
      5:10 PM 03/02/2016
      Cause of Tinnitus:
      Food poisoning.
      Haha no problem. I think we need a good chemist for this one.

      The first thing I do is look up the people. Those three are all biotech engineers at Roche in Switzerland, a big and pharmaceutical company. I think the patent under their own names is company owned and it's not even a formula, it's an open structure that could be many many things.
      I'm pretty sure they just applied for this patent to take advantage of the lack of knowledge of the patent bureau and to then sue anyone that tries to develop a cure using the same shape of molecule. Much like has been done often in the software patenting business. Given the other patents these inventors have it seems they do not have the intention of developing their 'discoveries'. Anyone else attempting this would have to negotiate a sizable fee with Roche.

      Also their company profile reeks of doo gooder bull, like how good people feel working for Roche and how they have a history in philanthropy.. Meanwhile they're company is publicly traded and they practice things such as hyping the influenza craze to sell vaccines to Europe's governments and make a killing on completely useless medications.
      Roche is one of those companies that is out for money and will lie, cheat, steal, and manipulate to get it. They regularly falsify clinical trial information.

      I don't think these guys are on our side.
       
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    19. Mario martz
      Creative

      Mario martz Member

      Tinnitus Since:
      02/2016
      Wow!! i didnt expect this! but i think you might be right, makes a lot of sense.
      but at least it means, that there must a formula that could work! :)
      i was thinking about this, on my way home.
      pharma makes big money out of illness.
      but i dont think there is a big industry behind mental illness (I MIGHT BE WRONG)
      psychologist and shrinks are always gonna have work :)
       
    20. Cityjohn
      Studious

      Cityjohn Member Team Research

      Location:
      Amsterdam
      Tinnitus Since:
      5:10 PM 03/02/2016
      Cause of Tinnitus:
      Food poisoning.
      I just figured out that their most sold drug (Roche), Benzodiazepine, is a major cause of tinnitus on this site. It increases the GABA metabolism which forces the body produce more glutamate. When people stop taking benzodiazepine they are left with glutamate toxicity and then, really bad tinnitus.
       
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    21. grate_biff
      No Mood

      grate_biff Member

      Location:
      Oslo, Norway
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      aucustic trauma, benzo withdrawl or both
      Is it reversable when things normalize in the brain?? That is the question!!
       
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    22. Cityjohn
      Studious

      Cityjohn Member Team Research

      Location:
      Amsterdam
      Tinnitus Since:
      5:10 PM 03/02/2016
      Cause of Tinnitus:
      Food poisoning.
      No, damaged CNS neurons can not be repaired conventionally.

      But given that Roche is best at destroying them, maybe they can figure out how to repair the damage.

      And then charge an ungodly amount of money for it.

      I'm really pissed off by this.
       
    23. Poyraz

      Poyraz Member

      Tinnitus Since:
      February 2016
      Cause of Tinnitus:
      Benzos, Stress, Anxiety, Loud Music, Jaw Problems. Who knows
      OMG! This gave me panick attack! So there is no hope for us?

      And I also want to ask why some people had T when they are in w/d and then got rid of it and some not?
       
    24. Cityjohn
      Studious

      Cityjohn Member Team Research

      Location:
      Amsterdam
      Tinnitus Since:
      5:10 PM 03/02/2016
      Cause of Tinnitus:
      Food poisoning.
      Please calm down, there is always hope.

      But looking at just Roche for help is not the answer, they used slave labor in WWII for crying out loud. They are not out to help people, the patent they applied for is there to F%^k people over that develop a cure for tinnitus using the same molecular structure. They have no idea whether it would work or not, that's why they listed a million neurological conditions it may cure.
       
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    25. Poyraz

      Poyraz Member

      Tinnitus Since:
      February 2016
      Cause of Tinnitus:
      Benzos, Stress, Anxiety, Loud Music, Jaw Problems. Who knows
      Thank you for explanation. I feel extremely sorry for myself. How I led my doc to destroy me. My life is all but gone. But I want to know something. These new upcoming drugs like SF0034, AM-101 will not help us at all? I do not want to wait for a false hope..
       
    26. bill 112
      Studious

      bill 112 Member

      Location:
      Republic Of Ireland
      Tinnitus Since:
      02/2012
      Cause of Tinnitus:
      Noise exposure
      Don't bother"waiting"Poyraz because it's a killer when it doesn't work out.We've all been there when Autophony bit the bullet something a lot of people here had high hopes for.Best advice is to get away from this and every few months drop in to get up to speed on current research and new treatments and then back away again.The cure isn't going to arrive anytime soon and the sooner you realise that the sooner you'll focus on you in the now and not what you may be in the future.
       
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