New US Government Research Funding for Hyperacusis

Major new research study to seek causes and therapies of hyperacusis and tinnitus. Funded by the National Institutes of Health, which is the medical research agency for the United States, in the amount of $420,000:

"The proposed studies are designed to increase our understanding of the neural mechanisms of hyperacusis and tinnitus and test the efficacy of novel pharmacological agents to treat these two debilitating disorders."

More details:

https://projectreporter.nih.gov/project_info_description.cfm?aid=9026749&icde=27773130

 

Are they testing Trobalt on humans or is this mice and rats?

DESCRIPTION (provided by applicant): Intense noise exposure and ototoxic drugs cause hearing loss and reduce the neural output of the cochlea. Paradoxically, cochlear damage often enhances neural activity in the central auditory pathway at suprathreshold intensities. This compensatory increase in the central auditory pathway is referred to as Enhanced Central Gain. Enhanced Central Gain is believed to be responsible for hyperacusis (loudness intolerance) and tinnitus, two debilitating conditions that afflict millions of Americans. The goal of this project s to experimentally test the Central Gain model to determine if it can account for hyperacusis and tinnitus induced by ototoxic drugs or intense noise exposure. To accomplish this, we will determine if the temporal and spectral properties of noise-induced or drug-induced hyperacusis match time course and spectral features of the electrophysiological metric of increased central gain in auditory cortex (AC), medial geniculate body (MGB), lateral amygdala and inferior colliculus (IC). We will also determine if the time course of noise-induced or drug- induced tinnitus is correlated with the time course and spectral features of hyperacusis and increased central gain in the AC, MGB, LA or IC. Since hyperexcitability disorders can be controlled by drugs that regulate potassium channel permeability, we will test the hypothesis that potassium channel modulators can suppress noise- or drug-induced hyperacusis and enhanced central gain. The proposed studies are designed to increase our understanding of the neural mechanisms of hyperacusis and tinnitus and test the efficacy of novel pharmacological agents to treat these two debilitating disorders.

 

Wish it was more like $420 million, but this is progress at this point. Glad to see money from the government.

 

Not sure on details beyond what NIH posted.

 

Progress. This is progress. More this.

 

Huh I misread this as .42Bn and not .42Mn.

.42Mn is enough to do, like, one blinded controlled human study.

 

At least this isn't another one of those sound therapy/CBT government funded study.

 

This is an animal study. Mice or rats.

 

420,000 is what a machine gun cost for their flagship fighter. They could figure out COLD yet they continue to show their fascist ways!

 

novel pharmacological agents-Benzos and so on. Its a farce!

 

that is nothing 420,000. can't do much of anything with that . need millions to fund good doctors and researchers . American government has failed us tinnitus sufferers .

 

Aman masterhoagie they have failed left us to the dregs. Im sick as can be not much time left in me. Bless you all your all my brothers and sisters. I love you all. Ruben

 

Mine was Meds and Stress also. How old are you, Ruben?

 

We must be so close to the cure, let's keep going!!!

 

Cure rolls of the tongue nicely. But lets hope for a treatment and go from there, first

 

420...lol

 

With those funds they can buy some camaro for students

 

@ReyKalinic
Do you live in Nimes in France ? Do you have Hyperacusis ?

 

Yes I'm full optionals; trigeminal nevralgia, reactive tinnitus and hyperacusys. what a wonderful world (R. Charles)

 

I'm from Montpellier. How did it happen ?

 

420,000 this is nothing absolutely nothing!

 

@ruben ruiz

American government prefers to prepare the war against Russia, China, & the rest of the world.