New US Government Research Funding for Hyperacusis

Discussion in 'Research News' started by lymebite, Jan 15, 2016.

tinnitus forum
    1. lymebite
      Breezy

      lymebite Member Benefactor Team Research

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Major new research study to seek causes and therapies of hyperacusis and tinnitus. Funded by the National Institutes of Health, which is the medical research agency for the United States, in the amount of $420,000:

      "The proposed studies are designed to increase our understanding of the neural mechanisms of hyperacusis and tinnitus and test the efficacy of novel pharmacological agents to treat these two debilitating disorders."

      More details:

      https://projectreporter.nih.gov/project_info_description.cfm?aid=9026749&icde=27773130
       
      • Like Like x 4
    2. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Are they testing Trobalt on humans or is this mice and rats?

      DESCRIPTION (provided by applicant): Intense noise exposure and ototoxic drugs cause hearing loss and reduce the neural output of the cochlea. Paradoxically, cochlear damage often enhances neural activity in the central auditory pathway at suprathreshold intensities. This compensatory increase in the central auditory pathway is referred to as Enhanced Central Gain. Enhanced Central Gain is believed to be responsible for hyperacusis (loudness intolerance) and tinnitus, two debilitating conditions that afflict millions of Americans. The goal of this project s to experimentally test the Central Gain model to determine if it can account for hyperacusis and tinnitus induced by ototoxic drugs or intense noise exposure. To accomplish this, we will determine if the temporal and spectral properties of noise-induced or drug-induced hyperacusis match time course and spectral features of the electrophysiological metric of increased central gain in auditory cortex (AC), medial geniculate body (MGB), lateral amygdala and inferior colliculus (IC). We will also determine if the time course of noise-induced or drug- induced tinnitus is correlated with the time course and spectral features of hyperacusis and increased central gain in the AC, MGB, LA or IC. Since hyperexcitability disorders can be controlled by drugs that regulate potassium channel permeability, we will test the hypothesis that potassium channel modulators can suppress noise- or drug-induced hyperacusis and enhanced central gain. The proposed studies are designed to increase our understanding of the neural mechanisms of hyperacusis and tinnitus and test the efficacy of novel pharmacological agents to treat these two debilitating disorders.
       
    3. Bran350
      Depressed

      Bran350 Member Benefactor

      Location:
      East Coast USA
      Tinnitus Since:
      08/2004
      Cause of Tinnitus:
      Acoustic Trauma
      Wish it was more like $420 million, but this is progress at this point. Glad to see money from the government.
       
      • Agree Agree x 2
    4. lymebite
      Breezy

      lymebite Member Benefactor Team Research

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Not sure on details beyond what NIH posted.
       
    5. ady

      ady Member

      Progress. This is progress. More this.
       
      • Like Like x 2
      • Agree Agree x 2
    6. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      Huh I misread this as .42Bn and not .42Mn.

      .42Mn is enough to do, like, one blinded controlled human study.
       
      • Like Like x 1
    7. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      At least this isn't another one of those sound therapy/CBT government funded study.
       
      • Agree Agree x 4
      • Like Like x 1
    8. This is an animal study. Mice or rats.
       
      • Informative Informative x 1
    9. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      420,000 is what a machine gun cost for their flagship fighter. They could figure out COLD yet they continue to show their fascist ways!
       
      • Like Like x 2
      • Agree Agree x 1
    10. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      novel pharmacological agents-Benzos and so on. Its a farce!
       
    11. masterhoagie

      masterhoagie Member

      Tinnitus Since:
      2012
      Cause of Tinnitus:
      over ear xbox headset monitor. kid yelled into Mic
      that is nothing 420,000. can't do much of anything with that . need millions to fund good doctors and researchers . American government has failed us tinnitus sufferers .
       
    12. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      Aman masterhoagie they have failed left us to the dregs. Im sick as can be not much time left in me. Bless you all your all my brothers and sisters. I love you all. Ruben
       
    13. LOU DENIRO

      LOU DENIRO Member

      Tinnitus Since:
      12/25/15
      Cause of Tinnitus:
      STRESS AND MEDICATIONS
      Mine was Meds and Stress also. How old are you, Ruben?
       
    14. Zeneth
      Doubtful

      Zeneth Member

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Very Unknown At This Point.... most likely loud sound?
      We must be so close to the cure, let's keep going!!!
       
      • Like Like x 1
      • Optimistic Optimistic x 1
    15. Pleasure_Paulie

      Pleasure_Paulie Member

      Location:
      Australia
      Tinnitus Since:
      06/2016
      Cause of Tinnitus:
      Noise..no idea.. unicorns?
      Cure rolls of the tongue nicely. But lets hope for a treatment and go from there, first :)
       
    16. RaZaH
      Not amused

      RaZaH Member Benefactor Team Tech

      Location:
      Reykjavík, Iceland
      Tinnitus Since:
      2012/04
      Cause of Tinnitus:
      Benzo + loud noise
      420...lol
       
      • Funny Funny x 2
    17. ReyKalinic

      ReyKalinic Member

      Location:
      NImes
      Tinnitus Since:
      2004/05
      Cause of Tinnitus:
      Triggered by TN
      With those funds they can buy some camaro for students
       
      • Like Like x 1
    18. Mithrandir
      Ape-like

      Mithrandir Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Acoustic Trauma + NIHL
      @ReyKalinic
      Do you live in Nimes in France ? Do you have Hyperacusis ?
       
    19. ReyKalinic

      ReyKalinic Member

      Location:
      NImes
      Tinnitus Since:
      2004/05
      Cause of Tinnitus:
      Triggered by TN
      Yes I'm full optionals; trigeminal nevralgia, reactive tinnitus and hyperacusys. what a wonderful world (R. Charles)
       
    20. Mithrandir
      Ape-like

      Mithrandir Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Acoustic Trauma + NIHL
      I'm from Montpellier. How did it happen ?
       
    21. ruben ruiz

      ruben ruiz Member

      Location:
      Tucson, AZ
      Tinnitus Since:
      2012
      Cause of Tinnitus:
      I believe it was meds and stress
      420,000 this is nothing absolutely nothing!
       
    22. Mithrandir
      Ape-like

      Mithrandir Member

      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Acoustic Trauma + NIHL
      @ruben ruiz

      American government prefers to prepare the war against Russia, China, & the rest of the world.
       

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