Progabide for Tinnitus?

Discussion in 'Support' started by JasonP, Sep 12, 2016.

tinnitus forum
    1. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      Some people on this form say they heavily benefited from Trobalt (Retigabine) for their tinnitus. Trobalt is a potassium channel opener. According to Wikipedia, there is a drug called Progabide that works on GABAb receptors. Wikipedia says that GABAb receptors can stimulate the opening of K+ channel which means a potassium ion channel. I know Trobalt is more targeted and a potassium ion channel may be different that a potassium channel but I was just curious. Unfortunately though, Wikipedia does not give a source for GABAb receptors being able open K+ channels and just states it. At any rate, has anyone tried this drug? Do you guys think it is worth a try?

      Retigabine works primarily as a potassium channel opener
      Source: https://en.wikipedia.org/wiki/Retigabine

      Via conversion into GABA, progabide behaves as an agonist of the GABAA, GABAB, and GABAA-ρ receptors.
      Source: https://en.wikipedia.org/wiki/Progabide

      GABAb receptors:
      They can stimulate the opening of K+ channels which brings the neuron closer to the equilibrium potential of K+, hyperpolarising the neuron.
      Source: https://en.wikipedia.org/wiki/GABAB_receptor

      This is probably like apples and oranges but I figured I would just ask if anyone tried it even for the additional GABAb receptor action.
       
    2. gotyoubynuts

      gotyoubynuts Member

      Tinnitus Since:
      10/1990
      Cause of Tinnitus:
      Concert
      Do we have brave Spaniards willing to buy this and try???
       
    3. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      Oh wow...I had no idea until now I could not get that in the U.S.! I was actually thinking about asking my doctor about it..oh well...how did you find out it was available in Spain? Is it available anywhere else?
       
    4. gotyoubynuts

      gotyoubynuts Member

      Tinnitus Since:
      10/1990
      Cause of Tinnitus:
      Concert
      Sorry I'm not sure if it's available in Spain but in Spain they sell people all types of drugs without prescription so I thought it's worth checking out.

      The Wiki pedia site says it's sold in France... is it only available in France? Why?? but it's under Prescription in France, not freely available
       
    5. JasonP

      JasonP Member

      Tinnitus Since:
      6/2006
      Yeah that is a good point...I wish it was it approved by France it would be approved in more places. Hey what did you think of the Riluzole drug thing I posted? Do you think it would be worth trying?
       

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