Pu-Erh Tea and GABA Attenuates Oxidative Stress in Kainic Acid-Induced Status Epilepticus

Discussion in 'Research News' started by Danny Boy, Jun 21, 2015.

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    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      • Hug Hug x 1
    2. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Abstract
      Background
      Pu-Erh tea is one of the most-consumed beverages due to its taste and the anti-anxiety-producing effect of the gamma-aminobutyric acid (GABA) if contains. However the protective effects of Pu-Erh tea and its constituent, GABA to kainic acid (KA)-induced seizure have not been fully investigated.

      Methods
      We analyzed the effect of Pu-Erh tea leaf (PETL) and GABA on KA-induced neuronal injury in vivo andin vitro.

      Results
      PETL and GABA reduced the maximal seizure classes, predominant behavioral seizure patterns, and lipid peroxidation in male FVB mice with status epilepticus. PETL extracts and GABA were effective in protecting KA-treated PC12 cells in a dose-dependent manner and they decreased Ca2+ release, ROS production and lipid peroxidation from KA-stressed PC12 cells. Western blot results revealed that mitogen-activated protein kinases (MAPKs), RhoA and cyclo-oxygenase-2 (COX-2) expression were increased in PC12 cells under KA stress, and PETL and GABA significantly reduced COX-2 and p38 MAPK expression, but not that of RhoA. Furthermore, PETL and GABA reduced PGE2 production from KA-induced PC12 cells.

      Conclusions
      Taken together, PETL and GABA have neuroprotective effects against excitotoxins that may have clinical applications in epilepsy.
       
    3. jimH
      No Mood

      jimH Member Benefactor

      Tinnitus Since:
      30 years+
      Cause of Tinnitus:
      Acoustic trauma
    4. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      has anyone tried this tea?
       
    5. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Only me it seems. Does make you really happy! So really does give you that GABA boost!
       
    6. Dave111
      Bashful

      Dave111 Member

      Location:
      Nederland
      Tinnitus Since:
      12/2013 worse 2/2015
      Cause of Tinnitus:
      Emotional abuse + recording guitar. Songname: Never give up -_-
      What did change exactly?
      Iam gonna try next week tnx.
       
    7. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      It just made me really happy and helped with depression.
       
    8. Dave111
      Bashful

      Dave111 Member

      Location:
      Nederland
      Tinnitus Since:
      12/2013 worse 2/2015
      Cause of Tinnitus:
      Emotional abuse + recording guitar. Songname: Never give up -_-
      But it did not lower T volume?
       
    9. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      It lowered it for me, but maybe I was just happy and ignored my tinnitus? Either way, it's worth a try. It's healthy, helps battle depression and can make your skin glow ^_^.
       
      • Helpful Helpful x 1
    10. dan
      Chatty

      dan Member

      Tinnitus Since:
      06/2011
      I would like to order 15 boxes of Pu-Erh tea please...
       
    11. Silvine
      Bookworm

      Silvine Member

      Tinnitus Since:
      03/03/2010
      Danny, in the article COX2 is mentioned. In your research have you come across any information regarding either COX or LOX as being a contributor to Tinnitus type neuro excitatory behaviours? The reason I ask is there are quite a few proven natural COX and LOX inhibitors in use at the moment which act in an anti inflammatory capacity.
       

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