Pu-Erh Tea and GABA

Discussion in 'Alternative Treatments and Research' started by Danny Boy, Aug 15, 2015.

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    1. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Pu-Erh is tea which contains caffeine plus GABA.


      Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport.

      Abstract
      We studied the transport of 14C-caffeine across the blood-brain barrier (BBB) by measuring brain 14C:3H ratios five seconds after rats received the caffeine, with 3H2O, by intracarotid injection. Caffeine was found to enter the brain by both simple diffusion and saturable, carrier-mediated transport. This latter observation suggested to us that caffeine's transport might involve macromolecules that are structurally similar to caffeine. Hence, we examined caffeine's ability to inhibit the BBB transports of 14C-adenosine and 14C-adenine. Caffeine caused a dose-dependent inhibition of 14C-adenine transport but no clear change in that of 14C-adenosine. At very high blood levels (Ki = 9.8 mM), caffeine may restrict the availability of circulating purines to the brain. This effect may be important neonatally, when carrier-mediated adenine transport apparently is maximal.

      Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus

      Background

      Pu-Erh tea is one of the most-consumed beverages due to its taste and the anti-anxiety-producing effect of the gamma-aminobutyric acid (GABA) it contains. However the protective effects of Pu-Erh tea and its constituent, GABA to kainic acid (KA)-induced seizure have not been fully investigated.

      Methods
      We analyzed the effect of Pu-Erh tea leaf (PETL) and GABA on KA-induced neuronal injury in vivo andin vitro.

      Results
      PETL and GABA reduced the maximal seizure classes, predominant behavioral seizure patterns, and lipid peroxidation in male FVB mice with status epilepticus. PETL extracts and GABA were effective in protecting KA-treated PC12 cells in a dose-dependent manner and they decreased Ca2+ release, ROS production and lipid peroxidation from KA-stressed PC12 cells. Western blot results revealed that mitogen-activated protein kinases (MAPKs), RhoA and cyclo-oxygenase-2 (COX-2) expression were increased in PC12 cells under KA stress, and PETL and GABA significantly reduced COX-2 and p38 MAPK expression, but not that of RhoA. Furthermore, PETL and GABA reduced PGE2 production from KA-induced PC12 cells.

      Conclusions
      Taken together, PETL and GABA have neuroprotective effects against excitotoxins that may have clinical applications in epilepsy.

      http://www.amazon.com/Yunnan-Pu-erh-Tea-12-Oz-340/dp/B002IY2VL2/

      http://www.amazon.com/Tea-King-China-Nannuoshan-Mountain/dp/B0086FQYAQ/
       
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    2. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Looks like nobody wants to drink this stuff? Seriously it does help with depression, is healthy and far better than any benzo.
       
    3. Robstarr

      Robstarr Member

      Location:
      London
      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Subsequent to an ear irrigation procedure
      I bought a couple of boxes from H&B

      Is fairly relaxing.
       
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    4. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Lovely GABA.
       
    5. bird

      bird Member

      Tinnitus Since:
      10/2014
      I bought some high-grade pu-erh from Ten Ren (a well-known specialty Chinese tea shop) and have been drinking it as per your suggestion. The higher-grades taste very good. I previously thought I didn't like pu-erh since I had tasted lower grade tea in the past. Anyway, I think it's having a positive effect on my mood and T, but this is pretty subjective so far. Regardless, seems like a healthy drink from most of the research out there.
       
    6. Lulubug69
      Artistic

      Lulubug69 Member

      Tinnitus Since:
      9/2013
      I bought some a while ago to help with metabolism and digestion. Tea is an overall good thing. Love the plus of helping with mood.
       
    7. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Potential for gaba withdrawal could still be the same as benzos?
       
    8. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I wouldn't have thought so. But, there's no data to say so.
       
    9. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      id consider trying it if it werent for my concern it may downregulate gaba like benzos can
       
    10. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Trust me, it's ok.
       
    11. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Ok... I'll try it...

      Another q ... I've avoided caffeine since t ... Should I be concerned about it containing caffeine?
       
    12. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      Please try to contact the company who sells it to get the information or ask a doctor.......Danny tries his best but he sadly does not know any more than you or I about it apart from he uses it and likes it and says it helps him and he has read the research.
       
    13. DebInAustralia

      DebInAustralia Member Benefactor Team Research

      Location:
      Geelong, Victoria
      Tinnitus Since:
      30/12/13
      Ask a dr? Lol....youve got to be joking..seriously! Ha!
       
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    14. amandine

      amandine Member

      Tinnitus Since:
      july 2014
      Yes you are right. Danny would know better as he has been using it so he will know better all about it..........yes doctor waste of time I know.....forget my post....silly idea posted when full of flu and not feeling well at all.....
       
    15. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Lol! What next, ask your doctor if green tea is ok to drink...haha
       
    16. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      If it was anything like benzos it would be taken off the market, but it isn't. I can drink it, children can drink it. It's safe, so don't worry, because every little thing will be alright.
       
    17. Blackbird26

      Blackbird26 Member

      Interesting they haven't taken alcohol off the market then yet...Well actually they did try that already, govt lost too much money, only 11 billion...while the " criminals" cashed in..Govt hates when that happens.
       
    18. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I think tea is quite different to alcohol, as in, it doesn't kill you...If it did I must be dead...I love me a cuppa tea <3
       
    19. Blackbird26

      Blackbird26 Member

      alcohol hits same receptors and benzos..it was tongue in cheek my friend. .

      I prefer coffee myself..ahh another wonderful legal drug.
       
    20. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Well, you can get decaf so it's not longer a legal high. I do with a with my coca-cola.
       
    21. Blackbird26

      Blackbird26 Member

      Well what is point of that? Might as well drink tea ;)

      ;p plus decaf tastes like shite.
       
    22. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Some people are caffeine intolerant...
       
    23. Blackbird26

      Blackbird26 Member

      it still tastes like shite.
       
    24. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Fair enough, but I like the fact that there's so many different varieties of tea..I do like my starbucks coffee though.
       
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    25. Blackbird26

      Blackbird26 Member

      ahh got ya! haha..Yea I grew up on tea..however considering my terrible sleep patterns, I praise the coffee gods every morning...otherwise I'd be a zombie.
       
    26. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      I like everything with cream, well in Starbucks anyway...Can't stand Costa though.
       
    27. Blackbird26

      Blackbird26 Member

      Percolator is only way to go for me..or espresso but SB espresso is...well....terrible.
       
    28. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Are you an American?
       
    29. Blackbird26

      Blackbird26 Member

      No I am not...but if someone pays me enough money, gladly will I become one...perhaps in Colorado or California.
       
    30. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      So where are you from, that is, if you don't mind me asking?
       

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