Stem Cell Transplant Treatment as a Reboot

Discussion in 'Research News' started by Lisa88, Jan 18, 2016.

tinnitus forum
    1. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      Just watched an interesting segment on BBC's Panorama which documents haematopoietic stem cell transplant treatment for MS. Amazing results are happening in terms of how it reboots the nervous system to pre MS.
      In terms of the CNS and nerve firings that correlate to tinnitus, this could be potentially exciting news.
      Here is an article on the treatment:
      http://www.theguardian.com/society/...-patients-hope-after-remarkable-trial-results
       
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    2. wizman

      wizman Member

      Location:
      Paris (france)
      Tinnitus Since:
      07/1987
      Cause of Tinnitus:
      fireworks
      I think It reboots the immune system not nerve cells in brain or spinal cord.
       
    3. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      Now this is what I like to see. Great article @Lisa88. Although we haven't had much extraordinary results from stem cell treatments on hearing loss, I think it's one of the biggest paths to take for reconnecting the damaged spiral ganglions of the auditory nerve back to the neurons in the brain and to the inner/outer hair cells.

      I'd say a good 80% of tinnitus is caused by damage between the hair cells in our ears and the brain. That connection in between is the much needed auditory nerve. If there was a way that we could reconnect these features of the inner ear then I strongly believe that tinnitus can be cured in the way that it should be. Scientists in Japan have been able to differentiate stem cells (I believe embryonic) to become neurons that were then transplanted into the ears of gerbils and were able to restore levels of hearing with them. The restoring of the connections in the ears will add many of tinnitus suffers that received it from noise. Loud noises damage the inner ear's nerves just like multiple sclerosis does. I'll attach an article below that talks about it below.

      Stem cells have a great chance of restoring problems with hyperacusis too. By reestablishing connections in the inner ear, the brains gain will return to normal since with hyperacusis, the loss of nerve connections between hair cells and the brain cause the brain to basically turn up its own volume so that it can hear better with the nerve to hair cell connection working correctly.

      Although I'm not sure how everyone got their tinnitus or how severe it is for them, I have to say that anyone that has gotten noise induced tinnitus/hyperacusis will benefit greatly from some kind of stem cell treatment that transplants neurons into their ears.

      Some articles to check out pertaining to all of this:

      http://www.neuroreille.com/promenade/english/pathology/tinnit/ftinnit.htm

      http://www.hear-it.org/loud-music-damages-nerves-brain

      http://atlasofscience.org/transplanted-cells-reveal-potential-for-functional-neural-regeneration-2/

      http://hyperacusisfocus.org/innerear/
       
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    4. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      See if you can watch that documentary. Very interesting. Somehow, rebooting the system helped restore the way nerves function. Some patients are even experiencing reversal of paralysis. I would still like to read a scientific brief on how these systems are interconnected.
      With tinnitus, I have read about so much effecting nerve function - brain chemistry, blood flow etc.
      A reboot does in theory sound so good.
       
    5. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      It is as @wizman said I'm affraid.

      Haematopoietic stem cells differentiate into blood and immune cells. It works for Multiple Sclerosis because it is an auto-immune disorder.

      I think the only type of stem cells that might help tinnitus are the pluripotent stem cells that can turn into new nerve cells. So far, those type of stem cells are of embryonic origin or induced in the lab from other types of stem cells.
       
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    6. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
    7. wizman

      wizman Member

      Location:
      Paris (france)
      Tinnitus Since:
      07/1987
      Cause of Tinnitus:
      fireworks
      It would be very interesting to know how T has evolued with people with T who have been through bone marrow or cord blood transplant for any (other) medical purpose.
      There must be a few ones in TT forum in this case.
       
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    8. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
    9. ady

      ady Member

    10. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      I'm sure the stem cells are able to repair the myelin sheath since people with multiple sclerosis have damaged ones. The auditory nerve in our ear does much more than just help one process sounds better. It's almost like a volume knob. The higher you turn it up (the more nerves you have on a hair cell frequency) the more clear and louder a sound will be picked up by that specific hair cell location for the brain to interpret. These nerves when functioning correctly not only do that but they act as neurotransmitters too when hair cells are in movement.

      http://www.buffalo.edu/news/releases/2012/06/13479.html
       
    11. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      Maybe you can do a search on youtube.
      Also, you may be able to watch it on bbciplayer through the Hola application on google chrome.
       
    12. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      There are people on theose forums who have tried experiment stem cell treatments in Bangkok. It's worth a read.
       
    13. Nick Pyzik
      Depressed

      Nick Pyzik Member

      Tinnitus Since:
      6/23/15
      Cause of Tinnitus:
      Listening to in-ear headphones & playing in a band
      Did they say what kind of stem cells were given to them and how were they transplanted?
       
    14. Nucleo

      Nucleo Member Benefactor

      Tinnitus Since:
      02/2011
      Cord blood IIRC.
       
    15. Bart
      Balanced

      Bart Member

      Location:
      Antwerp
      Tinnitus Since:
      05/06/2014
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    16. tomytl
      Grumpy

      tomytl Member Benefactor

      Tinnitus Since:
      10 Years
      Cause of Tinnitus:
      unknown
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    17. wizman

      wizman Member

      Location:
      Paris (france)
      Tinnitus Since:
      07/1987
      Cause of Tinnitus:
      fireworks
      Ateos i presume.
      But we need to know more about those who have been transplanted with bone marow with chemio before. ....
       
    18. monacco

      monacco Member

      Location:
      forte Antoine .monaco
      Tinnitus Since:
      29/09/2015
      Cause of Tinnitus:
      anknown
    19. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      Yes, the fact that stem cell transplantation is now helping to improve nerve function ... well that can only be a positive area of research for t.
      In the case of MS, looks like it is through the immune system. However, looks like it is also actually reversing the damage already caused to the nerves, which is very interesting in of itself.
       
    20. skoupidis

      skoupidis Member

      Tinnitus Since:
      09/2014
      Cause of Tinnitus:
      Acoustic trauma or mvc
      If they can cure the entire nervous system by fixing a genetic defect like MS, it is only logical to assume it is easier to fix a single area that was (possibly) functioning properly before getting damaged by, lets say, sound exposure. It doesn't have to be the exact same therapy, what good would that do, there can be variations or even an entirely different method. The point is: Nerve regeneration by stem cells should be obtainable in any part of the body. People that lost their sight can see again! We are not only talking about mobility here!

      Of course, let's hope they don't have to totally destroy the auditory nerve first in order to reboot it...:nailbiting: In MS cases it makes sense, since they do not know the cause, they simply erase everything! It is like when you cannot get rid of a virus that struck your PC, you have to format and reinstall the OS...

      The only negative part is, that unlike MS, hearing loss and Tinnitus are not considered to be life threatening. But I think they become aware of the importance day by day and, in light of these new stem-cell related miracles, they simply cannot stay dormant: The competition is rising which is a decisive factor in finding a cure and FAST!
       
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    21. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      Agree. I wouldn't want to risk a first clinical trial where they tell you "we need to destroy the audio nerve and see if we can "reboot" it" :woot:
       
    22. t-man
      Suicidal

      t-man Member

      Tinnitus Since:
      2009
      As a person of the great white north, I've always feared the dreaded MS. Nice to see we have an upcoming treatment for it. Though we've known for years a bone marrow transplant would cure it, the FDA considers that too drastic and would rather see people lose their legs, bladder and vision.

      Maybe it depends on the state of the condition. I have a hard time believing white matter can regenerate on it's own.
       
    23. Lisa88

      Lisa88 Member

      Tinnitus Since:
      11/2013
      Watch the documentary, and you will see lesions in white matter that have disappeared.
       
    24. lymebite
      Breezy

      lymebite Member Benefactor Team Research

      Location:
      United States
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      Unknown
      Has anyone tried stem cell therapy in Phoenix, Arizona with the Stem Cell Rejuvenation Center? They charge $7,100 and suggest they are a good alternative to traveling overseas for people in the United States:

      "We also aim to provide an affordable and quality US alternative to those who have been told that they have to travel overseas for treatment. Most of these trips can cost $20,000 to $50,000 and we want to offer a quality alternative for a fraction of the cost so that we can provide this potentially life-changing treatment for as many people as possible."

      http://www.the-stem-cell-center.com/component/content/article/39-deafness.html
       
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    25. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      I filled out an application form and they told me they had minimal success with NIHL. They said they where unable to offer a treatment at this time.
      I am not sure why they put the Pubmed documents on there website (most likely because I do not have any medical knowledge), but am glad that they are being honest.
       
      • Informative Informative x 1
    26. BohemianLife
      Alone

      BohemianLife Member

      Tinnitus Since:
      2001
      Cause of Tinnitus:
      Hearing loss
      @Reinier
      Did they say anything about ototoxicty about success?
       
    27. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      I filled out the application form you can find on the website. They only commented about my NIHL.
      Why not give it a go? There is no obligation to undergo any treatment.
      When they receive many requests for hearing issues they could be persuaded to give this more attention.
      But I am afraid that the "male shot" (see: the-stem-cell-center.com/o-shot.html) is getting "manly" more requests.:(
       
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    28. Leon909
      Ape-like

      Leon909 Member

      Tinnitus Since:
      09/2015
      I wonder why they say that it doesn't work while there have been other cases where it worked. And the protocol is not that different. The only difference is that at stemcells21 they take stem cells from you twice, so theoretically they would use twice the amount of stem cells. Maybe that is why this one in the US doesn't work. And now their cheap price isn't that cheap anymore because you only get half of what you get elsewhere for 15000 USD.
       
    29. Reinier
      Not amused

      Reinier Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      06/2015
      Cause of Tinnitus:
      Explosion starting engine
      I didn't want to follow this up with questions because than it will get to complicated for me. Biology was not part of my education. Realize that only a handful of anecdotal cases in the world report improvement. Out of thousands of people treated?
       
    30. Alue

      Alue Member

      Tinnitus Since:
      01/2016
      Cause of Tinnitus:
      Acoustic Trauma
      WTF is the "male shot" is it just an overpriced trimix injection? Really seems to lose credibility if that's the kind of thing they are peddling.
       

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