Suppressive Effects of Goshajinkigan on Tinnitus

Discussion in 'Research News' started by InNeedOfHelp, Jun 3, 2022.

    1. InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats

      Abstract
      Many people are affected by tinnitus, a sensation of ringing in the ear despite the absence of external sound. Goshajinkigan (GJG) is one of the formulations of Japanese traditional herbal medicine and is prescribed for the palliative treatment of patients with tinnitus. Although GJG is clinically effective in these patients, its behavioral effects and the underlying neuroanatomical substrate have not been modeled in animals. We modeled tinnitus using salicylate-treated rats, demonstrated the effectiveness of GJG on tinnitus, and examined the underlying neuronal substrate with c-Fos expression. Intraperitoneal injection of sodium salicylate (400 mg/kg) into rats for three consecutive days significantly increased false positive scores, which were used to assess tinnitus behavior. When GJG was orally administered one hour after each salicylate injection, the increase in tinnitus behavior was suppressed. The analysis of c-Fos expression in auditory-related brain areas revealed that GJG significantly reduced the salicylate-induced increase in the number of c-Fos-expressing cells in the auditory cortices, inferior colliculus, and dorsal cochlear nucleus. These results suggest a suppressive effect of GJG on salicylate-induced tinnitus in animal models.​

      There is also statistically significant evidence that this herb reduces neurotoxicity, neuropathic pains, and now tinnitus suppression in an animal model.

      Anyone with experience with this supplement? I guess it it is sold under a Western name too?
       
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    2. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
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    3. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      I'm game, this looks like a natural diuretic too.
       
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    4. Uklawyer

      Uklawyer Member

      Tinnitus Since:
      03/2020
      Cause of Tinnitus:
      Medication - antidepressants
      Imagine if this helped 40-50% of sufferers...
       
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    5. DebInAustralia
      No Mood

      DebInAustralia Member Benefactor Hall of Fame Advocate

      Location:
      Geelong, Victoria
      Tinnitus Since:
      12/2013
      Where can we source it?
       
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    6. AfroSnowman
      Balanced

      AfroSnowman Member Podcast Patron Benefactor Hall of Fame

      Tinnitus Since:
      04/2019
      Cause of Tinnitus:
      Nonnatural energy source
      Looks like it is available on Amazon and other online sites. It is sold as a bladder control supplement.
       
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    7. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
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    8. KoolKat

      KoolKat Member

      Location:
      USA
      Tinnitus Since:
      2013
      Cause of Tinnitus:
      HeadPhones/ Noise induced
      I would love if professionals tested this but apparently it takes 100 years just to start preclinical trials and another 5000 years to get to Phase 3 only for them to run out of funds or get deemed a failure.

      I guess we have to try it out ourselves.

      I can't believe they are only NOW testing this out. Are researchers really just now catching up with tinnitus?
       
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    9. El BUZZ
      Buzzed

      El BUZZ Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Loud music consumption plus acoustic trauma.
      Will try it as soon as possible.

      My friends and relatives are always telling me I'm a rat so this should work for me!
       
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    10. LostinTX
      Gloomy

      LostinTX Member

      Location:
      Arlington, TX
      Tinnitus Since:
      11/2020
      Cause of Tinnitus:
      poss ototoxicity/unknown/BVVP diagnosed first then tinnitus
      But this is for salicylate-induced tinnitus which in most people is usually reversed by cutting out salicylate rich foods and they improve within a few months just cutting that out. I still wouldn't knock trying it. But, I'd be more apt to find a potassium channel drug that works like Retigabine did, but safer.
       
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    11. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Yes it also has a huge anti-inflammatory effect so may help. It's not a pharmaceutical at least.
       
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    12. ibd

      ibd Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      acoustic shock
      Since I'm also suffering from peripheral neuropathy and another inflammatory rheumatic disease, trying this out seems ideal for me.

      Do we know from the links that @InNeedOfHelp posted, or otherwise, what would be an appropriate dosage for humans? The application of a drug for bladder control might have a different effective dosage than for tinnitus.

      EDIT:

      OK, I've since checked these publications. The first one used 1g GJG / kg body weight, which would definitely be too much when scaled up to human levels. The second one reads:

      "The standard daily dose of GJG prescribed for human use is 7.5 g, which contains 4.5 g of spraydried mixed extract."
       
    13. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      It being tested on a salicylate-induced tinnitus animal model, and giving suppressed tinnitus effects shortly after, does not mean that this is meant for salicylate-induced tinnitus. This is part of the standard tinnitus protocol in Japan as 'palliative' care. This study actually confirms the mechanism of action.

      The medical word of southeast Asia and western countries are split miles apart.

      The difficulty, as always with tinnitus, is, for which subgroup does it work and for which one doesn't?

      I'm going to give it a go, nothing to lose.

      If you buy this, make sure the ingredient list is equal to the original Japanese one. I already see plenty of bladder supplements if you Google these extracts. The ingredient list does not match the original Japanese one.

      https://bio-japan.net/tsumura-goshajinkigan-granules
       
    14. Jerad

      Jerad Member

      Location:
      Ohio; United States
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Medication ototoxicity
      Anyone going to try this?
       
    15. GlennS

      GlennS Member Podcast Patron Hall of Fame

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      Loud music
      LOL. Another treatment I know, but when reading this I suddenly have images of Susan Shore's head in a Futurama glass jar.
       
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    16. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      From Google:

      For both salicylate- and noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) receptor activation and related auditory nerve excitation have been suggested as origin of cochlear tinnitus. Accordingly, NMDA receptor inhibition has been proposed as a pharmacologic approach for treatment of synaptopathic tinnitus.​

      So this may work for my noise-induced tinnitus.
       
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    17. Jerad

      Jerad Member

      Location:
      Ohio; United States
      Tinnitus Since:
      2002
      Cause of Tinnitus:
      Medication ototoxicity
      Is your link for one that does match the ingredients properly? I found one here:

      Bladder Regulator, Gosha Jinki Gan An Effective Herbal Bladder Control Support Formula

      Would this one work?
       
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    18. AUTHOR
      AUTHOR
      InNeedOfHelp

      InNeedOfHelp Member

      Tinnitus Since:
      08/2021
      Cause of Tinnitus:
      MRI Scan
      I don't see an ingredient list in the study. But I would trust the product made for Japanese domestic market more, assuming it is a standard medicine there. I think their product would be quite generic, no matter which brand. Amazon shopping would be tricky I'd say especially if there are no proper ingredient lists.
       
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    19. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Well, I understand where you're coming from and your impatience is understandable but that's 50% => 70% of what it's all about. You know, tinnitus spikes, good days, bad days etc. and then when you try some new medicine or treatment, your tinnitus goes up or goes down, it's also dependent on mood or general health.

      So the hope is the @DebInAustralia's team (the Bionics Institute) can come along with their objective measure of tinnitus and provide some objective clarity.

      Failing that maybe they find some way of measuring the number of active hair cells -- inner or outer hair cells or the synapses.

      Suffice to say, there's no harm in trying or in searching for new treatments... the proviso being that they shouldn't do actual harm.

      :wideyed:
       
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    20. Hottopic29

      Hottopic29 Member Benefactor

      Location:
      Niagara falls
      Tinnitus Since:
      11/2013
      Cause of Tinnitus:
      Zithromycin acoustic trauma 2022
      Anyone try this yet?
       
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    21. ibd

      ibd Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      acoustic shock
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    22. Travis Henry
      Cynical

      Travis Henry Member

      Location:
      Dallas,TX
      Tinnitus Since:
      10/2021
      Cause of Tinnitus:
      1 Moderna Vac, Noise and stress I guess, its killing me
      How did you order it? I can't since I only know English.
       
    23. ibd

      ibd Member

      Tinnitus Since:
      2000
      Cause of Tinnitus:
      acoustic shock
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    24. Joeseph Stope
      Innocent

      Joeseph Stope Member

      Tinnitus Since:
      1992
      Cause of Tinnitus:
      noise? infection? negative stress? other?
      Who knows, maybe there is one magic herb out there. We just have to go through them all till we find it.

      Oh... and it matters whether the tinnitus is chronic or acute.
       
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    25. JPGL
      Frustrated

      JPGL Member Benefactor

      Location:
      Spain
      Tinnitus Since:
      10/2015
      Cause of Tinnitus:
      Hearing loss? Noise? Stress? Unknown
      It would be incredible if there was a herb that cured tinnitus.
       
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    26. BuzzyBee
      Bookworm

      BuzzyBee Member Benefactor

      Tinnitus Since:
      2016
      Cause of Tinnitus:
      Not Sure
      You could just try pumpkin seed oil. Now Foods brand is pretty good. It's a diuretic and supposedly anti-inflammatory. And if it doesn't calm your tinnitus, it will at least make your hair grow :) Seriously, though. Read the reviews on how it works as a diuretic. It seems to have the same properties as the Japanese herb.
       
    27. Nick47

      Nick47 Member

      Tinnitus Since:
      2015
      Cause of Tinnitus:
      Viral/noise
      Mine is not salicylate induced and I'm not a rat!
       
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