Tinnitus Psychopharmacology: A Comprehensive Review of Its Pathomechanisms and Management

Discussion in 'Research News' started by Danny Boy, Nov 4, 2015.

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    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management

      Abstract
      Background:
      Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line treatment for tinnitus, may modulate cochlear neurotransmission, thereby influencing the subjective tinnitus experience.

      Method:
      A comprehensive review of MEDLINE literature (from January 1990–January 2010) was performed searching for: “tinnitus”, major classes of psychopharmacological agents, and psychiatric disorders. The most relevant clinical evidence is reported briefly along with a concise description of the main neurotransmitters purported to be involved in tinnitus, in order to provide the reader with a rational evaluation of tinnitus therapy with psychopharmacological agents.

      Results:
      Although strong methodological issues limit the reliability of the current results, a broad number of psychopharmacological agents have already been considered for tinnitus, both as candidate triggers or potential therapies.

      Conclusions:
      Selected psychopharmacological drugs may play a role in the clinical management of this disorder. While the rational use of these agents for the treatment of tinnitus should not be overlooked, research should be undertaken on their neuromodulating actions at the cochlea.


      Read more:
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898164/
       
      • Informative Informative x 1
    2. Dutchy
      Not worthy

      Dutchy Member Benefactor

      Location:
      Netherlands
      Tinnitus Since:
      12/2014
      Cause of Tinnitus:
      Neuronmodulation suggests noise induced?
      Hmm,lidocaine.. I knew it's being used as a sedative but didn't know they tried it for T.
       
    3. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      There was going to be some patches at some stage, but nothing came of it.
       
    4. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Same stupid substances make their headlines one after another, year after year, and still nothing actually helps.

      I call dog's poop!

      Ok Lidocaine has evidently helped some people but the effect is very short lasting.
       
      • Hug Hug x 1
    5. Christian78
      Alone

      Christian78 Member

      Location:
      Gothenburg
      Tinnitus Since:
      (Sep 2013)
      Cause of Tinnitus:
      progressive tinnitus, time of expiring in next 3-6 months
      Those MADE IN SWEDEN :D

      He could not sell it here because he would go to court for fraud lol
       
    6. lapidus

      lapidus Member

      Location:
      Sweden
      Tinnitus Since:
      1999
      Cause of Tinnitus:
      Noise induced
      No, you're thinking of the Antinitus patches. The ones with lidocaine that Danny Boy mentioned are completely different and were invented for something else than T from the start.
       

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