Auris Medical (AM-102)

The beginning of this sentence is important... :
"The study failed to demonstrate a treatment benefit for the entire study population because mild-to-moderate ASNHL cases showed unexpectedly strong spontaneous recovery. In severe-to-profound ASNHL patients (threshold ≥60 dB), [...]".

 

Crap ,who are these spontaneous T recover. I'm hoping for that. the reason it was unexpected was because it was uncommon. They ran many trials before and thats never happened.

 

Made great progress on our second generation tinnitus project

http://ir.aurismedical.com/phoenix.zhtml?c=253572&p=irol-newsArticle&ID=2248196

 

Hi Larsen; the tinnitus of second generation is chronical (after 3 or 6 month) or is acute tinnitus (before 3 months) Thanks

 

Impossible to say. They will select the lead compound at the end of 2017. We'll have to wait a long time before anything is explained ! Auris didn't show great success after years of development on AM-101.

 

Meyer said (CEO) the targert is different from AM-101`s target, and have even
more therapeutic benefits than AM-101. so i hope chronical

 

There is a good reason (i think) that usually the go for early onset rather then chronic , if you think about it the test subjects .. rodents are usually given T so almost all test subjects have been early onset. It makes sense that they would want to roll this out focusing early onset and be close to their rodent test subjects..

 

Since AM101 has proven to have none, shouldn't be difficult !

 

I thought I read that AM-102 is for chronical T. They'll have at least much more suitable humans to test it on.

 

oh, ok

 

Yeah, thought I read it on their roadmap somewhere, might be wrong.

I mean that it's harder to find willing subjects for acute T, (because everyone hopes it might dissapear) and some will be way longer than 3 months before even starting to realise there is something as clinical trials for this medicine.

 

Yeah, but they can't. Might screw with their succes results.

 

I signed up for AM101 within a week of me getting tinnitus.
Part of the hard process of finding subjects that have acute tinnitus is the screening process. It was nearly 2 months before I got my first injection. I also think the 3 month time frame is really optimistic. More likely tinnitus becomes 'chronic' much faster than that.

 

yes, makes sense

 

Has it has not helped you at all with the injection?

 

One of the big problem with something like AM101 Is when people get the injection people are listing for they T to see if its gone, but when you start to listen for it, it gets louder and louder, even people who dont suffer from T in daily life can hear T just by focus on it. This could be a reason something like this show bad result many time.
Again could also be because it simply does not work.

 

It's supposed to be a cure or at least a huge relief.

The "If I listen to my T it's louder and louder" thing is not a good explanation. If there was a real benefit from AM101, people would know.

 

This is why having a placebo in the test is so important. Both the group with the placebo and the group with the drug will be listening harder than usual-- so if you see a difference in the groups, you can know it wasn't caused by that.

 

Minimal improvement. I stopped getting fleeting tinnitus in my ears, but my baseline tinnitus remained unchanged.

 

Is there any trial available to people 1 year after tinnitus onset in north america?

 

No trials anywhere for AM-102. No trials in North America for AM-101. I don't think anything has been trialed past one year. TACTT3 stratum B is up to 12 months.

 

Don't suppose Auris has done any trials in canada? Or upper west coast US?

 

Having been through the trial for Am-101 I would not recommend it as a) there is little proof it is beneficial b) it is not fun to have your ear drum punctured.

 

What about this TACTT3 stratum B it sounds interesting.

 

Since I started this thread more than two years ago, I wanted to inform those who have followed AM-102, that, today via a conference call concerning the full year 2016 results, Auris Medical stated that AM-102 is for the treatment of "acute tinnitus". The information is not in writing but was stated via the conference call only. The information was released by Thomas Jung as part of the slide covering AM-125 (slide #7 in the presentation).

This would seem to indicate that there is no immediate treatment for chronic tinnitus in the near (or distant) future therefore.

 

Not surprised.. Chronic T is in the brain.