Tinnex (Caroverine)

Discussion in 'Treatments' started by Markku, Mar 11, 2011.

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    1. Markku
      Inspired

      Markku Director Staff Benefactor Team Tech Team Trobalt Team Research Team Awareness

      Tinnitus Since:
      04/2010
      Cause:
      Syringing
      First, if you google only for "Tinnex", the first result will be this:
      And that's not what this discussion is about, maybe someone can create another discussion for that machine if they like. :)

      Wikipedia's article on Caroverine is really short and doesn't even mention tinnitus directly:

      This discussion / change of emails is from the 1990s: http://stason.org/TULARC/health/body/tinnitus-ringing-ears/9-21-Treating-Tinnitus-caroverine.html

      Caroverine itself is an old drug. Even though I don't personally recommend Arches' products (you can get the same ingredients cheaper by buying elsewhere), this article is pretty good on Caroverine: http://www.tinnitusformula.com/infocenter/articles/treatments/caroverine.aspx

      There is a clinical trial going, currently recruiting participants: http://clinicaltrials.gov/ct2/show/NCT01174979

      Anybody heard anything else about this? This is getting quite a buzz on Tinnitus sites since as far as I know the drug was recently approved in India. But I haven't heard of anyone getting the treatment yet...

      I will follow up in this thread if I myself find or hear more.
       
      • Informative Informative x 1
    2. rogerg

      rogerg Member

      One question:
      If this drug isn't new how come it hasn't been marketed as tinnitus treatment / cure before? Fishy.
       
    3. Anil

      Anil Member

      I am planning to go for tinnex treatment. Is it worth to go for this treatment?
       
    4. daedalus

      daedalus Member

      Location:
      Brussels
      Tinnitus Since:
      04/2007
      From memory from another forum: it was tried in Switzerland, Germany and Austria 14 years ago. Without success. It will be marketed in India. I would NOT try it.
       
    5. Markku
      Inspired

      Markku Director Staff Benefactor Team Tech Team Trobalt Team Research Team Awareness

      Tinnitus Since:
      04/2010
      Cause:
      Syringing
      This is currently the second most viewed discussion on Tinnitus Talk.

      Personally I haven't heard anything more about Caroverine/Tinnex than what I wrote in the first post of this thread.

      I'll be looking forward to that clinical trial completing.


      EDIT:
      It seems the clinical trial has been suspended.
       
    6. Arnold

      Arnold Member

      Location:
      China
      Tinnitus Since:
      2007
      Hi Markku:
      Can you tell me whether tinnex is useful to cure my tittitus?
      I learn Tinnex is a something like an injection medicine. Is it safe?
      It was invented by Lincoln pharmaceuticals Ltd in India.

      I do not know whether it had worked in India patients.

      I am hesitating.
       
    7. Arnold

      Arnold Member

      Location:
      China
      Tinnitus Since:
      2007
      Yes, Markku.
      I do not know anyone getting the Tinnex treatment, either.
      I dare not to use it firstly.
       
    8. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      Hello, Arnold
      Tinnex (Caroverine) treatment is only available in India.
      Lincoln Pharma, have launched it recently as an intravenous therapy, and then they top it up with a 20mg capsule of the drug Caroverine on a daily basis. Lincoln have an agreement with Phafag who made the drug in the first place. Its not a cure and I dont know how effective it is, however Lincoln claims its helped upto 61 percent of Tinnitus cases.

      http://www.hearingaidtest.com/2012/01/lincoln-pharma-launches-tinnex-capsules/

      http://www.facebook.com/photo.php?f...80337128.66798.166785426709491&type=1&theater
       
    9. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
    10. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
    11. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      They been doing it a year in India, where's the exposure 60 percent success rate is pretty good ??
       
    12. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      Has anyone tried this?
       
    13. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      There's rumours its going to hit international news channels Watch this space !!!!
       
    14. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      interesting that the suspended study was to have taken place in austria...and here is another study reported at NIH Pub Med that was completed in austria

      "Caroverine in tinnitus treatment. A placebo-controlled blind study."

      Denk DM, Heinzl H, Franz P, Ehrenberger K.

      Source

      ENT Department, University of Vienna, Austria.
      "Abstract

      "This study was performed to examine whether a single infusion of caroverine, a quinoxaline-derivative, can be used successfully in the treatment of inner ear tinnitus. Microiontophoretical experiments in guinea-pigs have shown that caroverine acted as a potent competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazone-proprionic acid (AMPA) receptor antagonist and, in higher dosages, a non-competitive N-methyl-d-aspartate (NMDA) antagonist. According to our working hypothesis of the pathophysiology of inner ear tinnitus (cochlear-synaptic tinnitus), these forms of tinnitus occur when the physiological activity of the NMDA and AMPA receptors at the subsynaptic membranes of inner hair cell afferents is disturbed. In total, 60 patients with inner ear tinnitus of assumed cochlear-synaptic pathophysiology were included in the study: after computerized randomization, 30 were treated with caroverine and 30 with placebo. For a response to have occurred, tinnitus had to show a reduction in both subjective rating and psychoacoustic measurement (tinnitus matching). In the caroverine group, 63.3% responded to therapy immediately after the infusion. In the placebo group, none of the patients treated showed a significant response according to the defined success criteria. The results confirm our working hypothesis on the genesis of cochlear-synaptic tinnitus."

      ---

      i wonder why the other study was "suspended

      and this stuff has been around for a long time and tried multiple times for treating tinnitus, on more than one occasion with significant reported success

      it doesnt make sense that we have not heard more about this treatment if it is effective...im confused
       
    15. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      Because Phag pharma did a deal with Lincoln pharma watch the video I posted above. Glutamine granules sit on top of the hearing receptors, the receptors miss fire due to disruption and this is tinnitus, however caroverine pushes out the granules allowing the receptors to be free again, tinnitus stops!! Wow Can this be real ??
       
    16. Jim
      Happy

      Jim Member Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      04/2007
      !

      Joe, I found this video very interesting and I could not see where you posted it in this thread so I'm reposting for all to see.
      Thank to Joe for finding it.
       
    17. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      Thanks Jim, I have contacted one of the members of the study, I have ask to confirm how long relief one can expect from a single infusion of caroverine, and if there's any way of getting this treatment in Austria.

      http://www.ncbi.nlm.nih.gov/pubmed/9442821
       
    18. Arnold

      Arnold Member

      Location:
      China
      Tinnitus Since:
      2007
      Hi , Joe, Thanks for your informations! By reading your information, I guess the caroverine can cure tiniitus. However, does caroverine make drugdependence
       
    19. Arnold

      Arnold Member

      Location:
      China
      Tinnitus Since:
      2007
      ????
       
    20. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
    21. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
    22. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      yes many people are craving caroverine and the data suggests this treatment is very promising

      here is a link that supports your advocacy for caroverine, (and i too am hopeful that this medication will live up to great promise thats indicated by all the excitement on the net)

      http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01174979

      at the heading there is a statement that the trial was suspended...why...very...very.... strange , and with all the promising work out of austria etc, this seems very fishy
       
    23. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      I can only assume that it was suspended due to Lincoln pharma having an agreement with Phfag for the Caroverine Molicule?
       
    24. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      Joe,
      did pfhag and lincoln pharma make an exclusive world wide distribution deal?

      if not, then why wouldnt phfag want to go ahead test and market in other countries?

      what you say may be true, and i hope it is but there are questions floating around out there
       
    25. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      joe

      what do these facebook comments mean ..whats the message we should be getting from reading the posts at the link you provided..i read them all and have my opinion but id like to reserve my judgement until i hear how you feel about it since you posted that link...what does it mean to you?
       
    26. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      I called one of the mobile numbers and spoke to amit who is a doctor who has adminstered caroverine Iv, he claims it has a 60percent success rate in Cochlear synaptic Tinnitus, the infusion he says will give 6 months relief. I dont know what to make of it, my head is one jumble at the moment, hence thats why I posted what you u think?
      Heres how its Administered http://www.tinnex.in/how-tinnex-is-administered.html
       
    27. Jim
      Happy

      Jim Member Benefactor

      Location:
      San Francisco
      Tinnitus Since:
      04/2007
      Did he give you any idea of how many times he personally has administered the treatment and the results of his efforts. It sounds like he is just quoting the stats given by a sales rep.
      I will remain skeptical yet hopefull until I hear some testimonials from patients who who have had the treatment and are happy with the outcome.
       
    28. mock turtle

      mock turtle Member

      Location:
      puget sound
      Tinnitus Since:
      07/26/1992...habituated after 2 years; 11/04/11 new outbreak
      Joe
      what i make of it is there is much to be persuaded by and many questions still unanswered and like you, my mind is jumbled up over these questions because caroverine is in a class of drugs that should work, but so far i have not seen the testing and data and EU or Canadian or USA FDA type endorsements i would like

      and im so puzzled by all of this cuase if caroverine works, its got to be a powerful money maker for docs and pharma given all of us who are in pain and willing to pay to make the pain stop or even just decrease measurably

      i appreciate your research...lots of research...but im still only 50 50 on this at best

      thanks
      mock turtle
       
    29. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
      Guys, I have really dug deep if you go on the Facebook page there are testimonials that have been posted by Lincoln pharma, along with results and patients mobile and home numbers of some, data protection obviously doesnt exist for these patients. I haven't called any of the testimonials yet, but I think I should and speak to someone who has gone through with it. The genesis of Caroverine and how it targets glutamine granular deposits that are in limbo in the hearing receptors, this makes obvious sense as once these receptors have been cleared of glutamine deposits once caroverine antagonises they will stop misfiring resulting in possible elimination of Tinnitus. I would like to contact Dr Klaus Ehringberger as I have so many questions that for me would conclude if I should proceed personally with the infusion. The other point is Caroverine is available in Austria where I Believe Dr Ehrinberger resides, It would be beneficial if This treatment was available in Austria as its not as far to go. What do u think
       
      • Like Like x 1
    30. joe

      joe Member

      Location:
      UK
      Tinnitus Since:
      October 2011
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