Tinnitus Research at University of Laval - Quebec

Hey folks,

Just stumbled on that article in the french Quebec website QuebecMatin, that i googletranslated :

"Un espoir pour ceux qui souffrent d'acouphènes"

I never heard anything about that University, so I contacted Dr Guitton and asked him if his compound was AM101, he answered that he couldn't tell me anything about his research today.

Have you heard about them ?

 

"... if a pharmaceutical company is interested."

That one I think is pretty safe lol.

Imagine the money a company selling a tinnitus-mute-drug that costs 100$ a month would make..

 

I was listening to Dr Guitton video, as my mother language is French i understood all what is said. the interview was taken on 9th October 2013. The medicament he discovered is new (not AM101)

Conducted tests from an injected rats molecule. Recently, a laboratory in the United States was conducting the first clinical trials in humans with the disease recently.

The good new he said that trial on human get good results all 100 % of the cases and all tinnitus kinds, at least there is an improvement.
The drug will be on our hand in 5 years he said

Here is the video link:

http://www.radio-canada.ca/regions/...s-recherche-medicament-universite-laval.shtml

 

Whaaaaat? That is pretty cool if it's legit!

 

Is this even with chronic tinnitus or is there a specific time-frame for it to work ?

All this news gives so much hope


DR. MATTHIEU GUITTON
Faculty of Pharmacy, Laval University
$20,000

Analysis of long-term involvement of synaptic plasticity in tinnitus
Tinnitus is a perceived noise in the ears such as ringing, buzzing, or clicking. This perception of noise may be caused by irritation or damage to the auditory nerve. Transient exposure to noise may irritate the auditory nerve causing reversible tinnitus. Prolonged exposure over time may cause intermittent or permanent tinnitus. Because noise pollution is a serious environmental problem, it is estimated that close to 1% of the North-American population suffers from tinnitus. Although tinnitus affects adversely the quality of life of individuals afflicted with this problem, there are at present no effective remedies for this condition. Dr. Guitton proposes to study the neural pathways that are triggered by damage to the auditory nerve to evoke tinnitus in a rat model. By identifying the neurotransmitters and receptors that propagate signals in these pathways, it is anticipated that pharmacological agents can be designed to selectively block these pathways and offer relief to individuals suffering from tinnitus.

http://www.utoronto.ca/bantresf/Grantees/Guitton.html

 

Wow hey nills I think I know you from the good old dayes have you been to Copenhagen.
If that is real we can just relax sit Down and wait five years.

 

Sweet. Maybe this is it!

 

imagine being able to experience silence again.... seems like a dream to me crossed fingers over here!

 

If this guy has promising results I am very excited. Reading the top result on Google (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297194/) has convinced me that he is not just hocus-pocus. He seems to consider the big picture in that article.

I would just very much like to know if his testing is on chronic tinnitus. Does that interview say anything about that?

'Récemment, un laboratoire aux États-Unis effectuait les premiers essais cliniques sur des sujets humains présentant la pathologie depuis peu' means resent onset, right?

 

It is not specified if it works for all tinnitus cases however chronic tinnitus is independently mentioned as "The laboratory of Professor Guitton also works for the realization of a prosthesis for the long term tinnitus." I think it is probably for acute cases.

 

Could also mean, that it isn't enough to inject the medication only once, so that chronic T patients would need a prothesis that continuously releases medication into the ear or something.

 

Well in that case you're gonna have to cut wholes in your ear drums many times which will ruin them I think

 

basically that is what they do with tympanostomy tubes, isn't it? I didn't know that that would ruin your ear drums... ok so maybe my idea of what could have been meant by prothesis was wrong after all.

 

You're right. I remember that now. Sorry. Every 6 months or something.

 

But is it really relevant to any of us? Or only people who have had it for 3 months and less?
(I guess it's relevant just for our curiosity, but I mean relevant as in able to help us)

 

Thanks erik when suffers lose hope you grip them and give them a new.

 

A prosthesis? A thing in our ears? Or is this a word that can mean several things?

 

@James if you want to know more about this you must watch that report : "Les accouphènes", Découverte - Radio Canada, February 28th 2010 (in french). I live in Quebec and I have been following Guitton's work since 2011. I always thought he was working on AM 101 or something very similar! www.radio-canada.ca/emissions/decouverte/2009-2010/Reportage.asp?idDoc=104908

 

I forgot to mention, when I first got tinnitus in 2011 I wrote to Mathieu Guitton and he has been very nice. He told me he had been working on a molecule that can treat recent-onset tinnitus but that we would have to wait a few years (clinical trials, etc.) before it could reach the market. He told me at the time that his team was also doing research on a way to stop chronic tinnitus. He added, "Il y a de l'espoir", "There is hope"!

 

If you have chronic tinnitus, and "fix" the ear... Surely there must be a way to sort of "trick" the brain to forget the sound?

Listen to white noise for A YEAR and it must be gone? What?

 

God bless this French Messiah of our hope and thanks to each of you for bringing this encouraging news to us. God, please rain down on us with your goodness and cure us as you once did the Leopards.

 

It`s called brain placticity ...the brain adapts to every new modality that asks it`s attention.

 

Thanks for the link, they are talking about both his molecule and AM101 in that documentary. It was interesting to see people live with tinnitus but didn't focus enough on research, still too early to develop i guess.

 

Exactly! The brain is plastic, it adapts and changes. That is why I think that if you fix what's wrong in the inner ear, fixing your brain should be very possible.

At least that's what I hope...

 

Have him do an AMA like they do on reddit. He says I Am This Dude

and then we ask him quesions and he answers. Would be great