Anticonvulsant Activity of Aloe Vera Leaf Extract

Discussion in 'Alternative Treatments and Research' started by Danny Boy, Nov 4, 2015.

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    1. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice.

      Abstract
      OBJECTIVES:
      The effect of Aloe vera in epilepsy has not yet been explored. This study was done to explore the effect of aqueous extract of Aloe vera leaf powder on three acute and one chronic model of epilepsy.

      METHODS:
      In acute study, aqueous extract of Aloe vera leaf (extract) powder was administered in doses 100, 200 and 400 mg/kg p.o. Dose of 400 mg/kg of Aloe vera leaf extract was chosen for chronic administration. Oxidative stress parameters viz. malondialdehyde (MDA) and reduced glutathione (GSH) were also estimated in brain of kindled animals.

      KEY FINDINGS:
      In acute study, Aloe vera leaf (extract) powder in a dose-dependent manner significantly decreased duration of tonic hind limb extension in maximal electroshock seizure model, increased seizure threshold current in increasing current electroshock seizure model, and increased latency to onset and decreased duration of clonic convulsion in pentylenetetrazole (PTZ) model as compared with control group. In chronic study, Aloe vera leaf (extract) powder prevented progression of kindling in PTZ-kindled mice. Aloe vera leaf (extract) powder 400 mg/kg p.o. also reduced brain levels of MDA and increased GSH levels as compared to the PTZ-kindled non-treated group.

      CONCLUSIONS:
      The results of study showed that Aloe vera leaf (extract) powder possessed significant anticonvulsant and anti-oxidant activity.

      Source:
      http://www.ncbi.nlm.nih.gov/pubmed/24251823
       
    2. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Nothing so far in human trials indicate anticonvulsant medications will be our Holy Grail.

      You get too excited about all anticonvulsants, @Danny Boy. :p
       
    3. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      You do realise that trobalt is an anticonvulsant as is clonazepam? And they seem to work for people.
       

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