Evaluation of the Effects of Charged Amino Acids on Uncontrolled Seizures

Discussion in 'Research News' started by Danny Boy, Feb 5, 2016.

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    1. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      "Two products of arginine: glutamic acid and agmatine may be involved for anticonvulsant effects of arginine.

      Administration of arginine and glutamic acid can be effective in reducing the seizure frequency of uncontrolled epilepsy patients, without triggering considerable complications."

      http://www.hindawi.com/journals/nri/2015/124507/

      "Agmatine was found to exert modulatory actions directly and/or indirectly at multiple key molecular targets"

      • Neurotransmitter receptors and receptor ionophores. Nicotinic, imidazoline I1 and I2, α2- adrenergic, glutamate NMDAr, and serotonin 5-HT2A and 5HT-3 receptors.
      • Ion channels. Including: ATP-sensitive K+ channels (Potassium channel)
        , voltage-gated Ca2+ channels, and acid-sensing ion channels (ASICs)."

      "Glutamic Acid is converted into GABA (gamma aminobutyric acid) or glutamine both of which serve essential purposes in passing messages around the brain.

      Like all amino acids, Glutamic acid is one of the numerous components of our proteins and while it is synthesised naturally inside the body, we often find ourselves with depleted levels."
       
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    2. Atlantis

      Atlantis Member

      Tinnitus Since:
      02/2014
      Are you going to try these Danny?
       
    3. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
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      Possibly. I'm just compiling information at the moment.
       
    4. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

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      Concerning neuroprotection, agmatine's effects are thought to involve modulation of receptors (NMDA, alpha 2, and imidazoline) and ion channels (ATP sensitive potassium channels and voltage-gated calcium channels) as well as blocking nitric oxide synthesis. Agmatine blocks nitric oxide synthesis by reducing the nitric oxide synthase -2 (NOS-2) protein in astroglial cells and macrophages. With respect to agmatine's benefit in psychiatric disorders, it is suggested that the mechanism involves neurotransmitter receptor modulation of the NMDA, alpha-2, serotonin, opioid, and imidazoline receptors. Specifically when agmatine binds to the imidazoline and alpha 2 receptors, it acts as a neurotransmitter and releases catecholamines from the adrenal gland.

      As an experimental drug, agmatine is being studied for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety, schizophrenia, and cognition). The exact mechanism of action is still being investigated for all of the potential indications of agmatine.



      http://www.drugbank.ca/drugs/DB08838

      Hm...So Agmatine works on the potassium channels and NDMA receptors as well as calcium channels.
       
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    5. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
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      1998
      Aren't you also on Trobalt and possibly other drugs, @Danny Boy? Doesn't that make it more or less impossible for anyone to know what is doing what effect, what interactions there might be, etc?

      Sorry, but it seems like every week you have some new supplement, drug or approach which you become convinced is "helping" -- and yet you still have tinnitus, and you're still on Trobalt?
       
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    6. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
      Ear infection
      I don't want a cure, just a reduction. Plus, I found it quite interesting.

      Also, here are the biointeractions
      http://www.drugbank.ca/drugs/DB08838/biointeractions
       
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    7. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      yeah that more or less explicitly confirms that it's got secondary and tertiary interactions with RTG....
       
    8. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Ear infection
      Where does it say that?
       
    9. linearb
      Psychedelic

      linearb Member Hall of Fame

      Location:
      East Coast USA
      Tinnitus Since:
      1998
      it says it's a potassium channel antagonist, so there's some kind of direct/secondary interaction there. It also says it's an NMDAR antagonist, which means it's got secondary/tertiary interactions with RTG's GABA activity (NMDA and GABA work in opposition).

      edit; ah, it's a Kv1.1 targeter, so, possibly not much direct interaction with RTG at Kv channels... but, it's hitting a whole ton of buttons, and clearly has significant overlap at least along GABA-mediated inhibition. Until evidence to the contrary emerges, I will remain convinced that a big part of RTG's tinnitus impact relates to GABA. Kv channels have been pretty conclusively shown to be part of the problem that initially creates tinnitus, but I also remain convinced that the long-term maintenance of tinnitus hyperactivity has more to do with LTP and problems with inhibition.

      Interesting stuff, anyway.
       
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    10. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
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      Tinnitus Since:
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      Cause of Tinnitus:
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      It does work on the calcium channels, so there'd be a gabapentin interaction.
       
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    11. no life

      no life Member

      Where can I get this from
       
    12. Danny Boy
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      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Ebay.
       
    13. Jahhsoul
      Curious

      Jahhsoul Member

      Location:
      Spain
      Tinnitus Since:
      9/24/2015
      Cause of Tinnitus:
      Unkown (not acute acoustic trauma).
      Hey Danny Boy, good job on look for new drugs which could work for Tinnitus suffers. Continue this please I read all your post and get some hope even they are not the final cure for us.
       
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    14. Danny Boy
      Cheerful

      Danny Boy Member Benefactor Hall of Fame

      Location:
      England
      Tinnitus Since:
      7/2014
      Cause of Tinnitus:
      Ear infection
      Thank you for your support. I will ^_^.
       
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