Withdrawn/Terminated Safety Study for NST-001 and the Neuroject Injection Set to Treat Tinnitus

To investigate the safety of NST-001, delivered directly to the inner ear.

    1. Tinnitus Talk

      Tinnitus Talk Knowledge Base

      Tinnitus Talk submitted a new resource:

      Safety Study for NST-001 and the Neuroject Injection Set to Treat Tinnitus (version 1.0) - To investigate the safety of NST-001, delivered directly to the inner ear.

      Read more about this resource...
    2. nookie

      nookie Member

      Tinnitus Since:
    3. Fish

      Fish Member Benefactor

      Tinnitus Since:
      July 2012
      Very interesting, I wonder what is the substance in NST-001. Probably also nmda antagonist to suppress excessive glutamate. The whole thing looks similar to AM-101. If only there was some other way to administer the drug other than middle ear injection :(

      Another thing that makes me wonder is 10-year limit inclusion criteria. With AM-101 it is 3 months. I have a feeling those time limits are completely arbitrary...

      EDIT: this study hasn't been updated for almost a year now, I wonder what happened.
    4. nookie

      nookie Member

      Tinnitus Since:
      If you ask me they can administer the drug from any point or hole they want on me as long it becomes quiet in my ears.

      Now what I read somewhere they did trials before and they searched for people before who had TT maximum 1 year, and i guess they want to see if they get any success with people who have TT for longer time.

      Now they must have some results since the study started 2009 and was supposed to end at december 2012.

      Here is another link of the study: http://clinicaltrials.gov/ct2/show/NCT00957788
      and there is an emai to contact person so maybe someone should give a try and contact them and ask them for results..

      More about the company behind: http://www.neurotechreports.com/pages/tinnitus.html
      I think this is the patent of the drug: http://www.faqs.org/patents/app/20120208848

      Man I'm like Kojak ;) Enjoy the reading :)
    5. nookie

      nookie Member

      Tinnitus Since:
      An update, and not good one for us who have tinnitus more then a year. Suck =(

      A new drug can help ease the discomfort of tinnitus when pumped into the inner ear, according to a recent study.

      A powerful new medicine, named NST-001, has proven to be effective in calming the overactive nerves in the inner ear thought to cause tinnitus. Directly pumped into the inner ear, the drug could block the production of excessive glutamate, a brain chemical, which hyperactivates nerve cells. Such hyperactivity occurs, for example, when hearing is damaged in some way, for instance by exposure to loud noise.
      At the research stage

      Animal research has found that when the drug was placed in the ear, it reduces the sounds of tinnitus. And in a small pilot study on human volunteers in Germany, the majority of patients given the drug reported a significant reduction of tinnitus.

      Dr Ralph Holme, director of Biomedical Research at the Royal National Institute for the Deaf, says: β€œIn recent years, there has been research into a number of drugs which aim to reduce the hyperactivity in the brain associated with tinnitus. This particular study is interesting, as it is also testing a new way of administering a drug by pumping it straight into the inner ear.”

      Development of a pump

      Studies have however also shown that the effect of the drug is only present during the treatment. After which, the tinnitus returns to the previous levels. The researchers are therefore focused on developing a fully integrated drug pump. The pump must have an internal reservoir that will administer the drug for more than a year, after which it will be refilled through the skin via a minor surgical procedure.

      This new treatment is primarily meant for patients who have had tinnitus for less than a year, as the treatment must act during the phase when the tinnitus is still only linked to disorders in the internal ear. As of yet, it is unknown whether it will work in well-established tinnitus.
    6. Aisling

      Aisling Member

      Tinnitus Since:
      Why does the clinical trial for this drug state that you must be deaf to be included?
    7. christy

      christy Member

      Tinnitus Since:
      I read something that said clinical trials were stopped. But that article was from 2009. Is this available in the US? I guess I will make (yet another) appointment with my ENT and ask him. *Sigh*
    8. jazz
      No Mood

      jazz Member Benefactor

      Tinnitus Since:
      Cause of Tinnitus:
      eardrum rupture from virus; barotrauma from ETD
    9. t-man

      t-man Member

      Tinnitus Since:
      Honestly, don't put any hope into a medication helping us chronic suffered, at all.

      I'd put more faith in new treatments involving tampering with brain plasticity. And this new form of treatment looks every promising with two electrical stimulus devices on the way.
    10. Dubbyaman

      Dubbyaman Member

      Northern Indiana
      Tinnitus Since:
      Cause of Tinnitus:
      Excessive loud noise
    11. James White

      James White Member Benefactor

      Toulouse, France
      Tinnitus Since:
      April 2013
      Cause of Tinnitus:
      Maybe loud music. Not sure.
      • Like Like x 1
    12. nills

      nills Member Benefactor

      Tinnitus Since:
      Cause of Tinnitus:
      acoustic trauma
      the clinical trial says

      Inclusion Criteria:

      • Patients able to provide voluntary consent.
      • Severe tinnitus in one ear that began no more than ten years ago.
      • Ear to be treated must be deaf or have profound hearing loss.
      • Subjects with cardiac disease or hypertension, must have stable disease for at least 6 months.
      • Subject must have intact cochlear nerve on the ear to be treated.
      • Women of childbearing potential
    13. Goldilocks

      Goldilocks Member

      Sydney Australia
      Tinnitus Since:
      Cause of Tinnitus:
      Original T 1995, aggravated T 2014, increase 2016
      Does anyone know what happened to this NST-001 drug?
      • Agree Agree x 1
    14. Champ

      Champ Member Benefactor

      Boston, MA
      Tinnitus Since:
      Cause of Tinnitus:
      Acoustic trauma from headphones
      Seriously, nothing?
    15. beeeep

      beeeep Member

      Tinnitus Since:
      ~2000, but real bad since 06/2015
      Cause of Tinnitus:
      See the post of @James White above. Otonomy has taken over the research, and this is probably OTO-311.

      Otonomy Press Release


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