Recent content by sami23

What about the eardrum perforation after being injected with FX-322? Does the the hole in the eardrum heal afterwards? Will it be as good as before the injection?

Okay, thanks a lot. So the better the hearing was before the injury (noise trauma for example), the better the results will be with FX-322?

Can we hear at 19 18 20 kHz after FX-322?

Why do support hair cells die in profound hearing loss?

I don't think so, that's too premature. But we don't know if the results of the Phase 2a are on another level and beyond what we thought. The important point is the low frequencies, mostly those which encompasses speech. If they can reach it, I think this drug has nothing more to prove.

That picture is from a Russian doctor but I don't know where he got it.

I found an interesting picture of a mouse's cochlea after FX-322 injection. Here it is: Hair cells created are in good shape in my opinion.

Yes, noise affects support cells but it depends on the volume level/time of exposure. It would be interesting to know how much noise affects it, if the cell would be still able to regrow or no.

Okay, thanks a lot, so it means that FX-322 could potentially be available by 2022. Interesting.

If they continue to show positive results, can they skip Phase 3 and directly launch FX-322 into the market?

How many hair cells can FX-322 regrow with a single shot? Will our ears become as good as they were before we got our hearing loss / tinnitus?

How do we know if we have dormant hair cells in our cochlea?

Okay thanks a lot. I have one final question. My acoustic otoemission (OAE) has decreased with noise trauma, is this sufficient to prove that there is hair cells loss? I don't have hearing loss but tinnitus and daily sounds are very unpleasant when I hear them (like sirens, motorbikes...

Hey, do you think that once Phase 2a clinical trials are completed, Frequency Therapeutics will do clinical trials in other locations (outside of the US)?