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  1. J

    Long-Lasting Total Remission of Tinnitus: A Systematic Collection of Cases

    Do you recall the lively discussion with Tom Cync, who managed to emerge from the depths of tinnitus and hyperacusis by somehow “weathering it out” and trying to get used to loud noise? https://www.tinnitustalk.com/threads/im-fine-%E2%80%94-tinnitus-is-basically-not-a-thing-anymore.55510/...
  2. J

    Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration

    This looks like a goldmine. For those of us who are not very scientific, the overall picture is beginning to emerge. Very often the source of our tinnitus and hearing loss lies in the cochlea, but it can also reside in the brain, or in both the cochlea and brain together. In the search for a...
  3. J

    2024 US Presidential Election

    I lived in the States around 1989, in Washington, D.C. One of the scariest events I remember was when the gay community held “AIDS Action Week” and spread out a quilt on the Mall behind the White House. It must have covered at least one square kilometer. Each quilt piece had embroidery, a photo...
  4. J

    2024 US Presidential Election

    My deepest sympathies go to the Kirk family, and I want to extend them to all of the United States. Am I a Biden supporter? I suppose I am, or perhaps I was, although I am not American. For me, America has always been that wonderful land of optimism and good humor, where people were open and...
  5. J

    Studies Confirm Tinnitus Improves Over Time

    In the case of early-onset tinnitus patients, I can easily understand the difficulty of wrestling with a changed auditory world of constant ringing, twenty-four hours a day, seven days a week. That would naturally involve a psychological factor—the panic of trying to find a therapy or medicine...
  6. J

    2024 US Presidential Election

    Ha! Quite amusing, but it is not enough to go on. By the looks of things, Donald seems to like big blonde women—there’s Ivanka and his previous wife. I must confess that I also find big blonde women attractive, so I cannot cast the first stone. In my view, the real question is: how could Donald...
  7. J

    2024 US Presidential Election

    @Luman, ummm… I think the world is entering a dangerous stage right now, and from various angles. You can pick and choose which one feels the most immediate or the most dangerous. Climate change? The hottest summer on record. I will never be a movie star now, Hollywood has burned out. Security...
  8. J

    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    Many thanks for taking the time and effort to explain things. It lifts our spirits to have a member who is on top of their game in auditory matters.
  9. J

    2024 US Presidential Election

    Show me the data! And I say that with some embarrassment, as I learned today that Trump is lambasting the Europeans—for what? For buying cheap Russian oil. No surprise there. My guess is it is probably the Hungarians or the Slovakians, since they are often eager to please Putin regardless of...
  10. J

    2024 US Presidential Election

    https://www.irishtimes.com/opinion/2025/09/03/trumps-persistent-idiocy-has-hugely-diminished-americas-standing-in-world-affairs/ Trump's persistent idiocy has hugely diminished America's standing in world affairs US president confuses anxiety and obsequiousness he produces in other world...
  11. J

    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    Bowled over by your scholarship in this specialized area of medicine. I recall one post from @Nick47, not so far back, I believe from this year, where he mentioned that some form of delivery method, specifically injection, had fallen into disrepute. Was it the intra-tympanic delivery or the...
  12. J

    2024 US Presidential Election

    Image-wise, it looks like Trump has dropped a clanger. He imposes his 50% tariff on India, allegedly because they are buying Russian oil and gas. China then steps in to take up the slack and supports India with a favorable trade deal. Who wins, who loses? I suppose the market will tell. China’s...
  13. J

    Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure

    View from the back of the class. Well, I guess the study might be useful in its own way. When rejuvenating the hair cells or synapses, it is important to keep the noise level down for a few weeks.
  14. J

    NervGen Pharma’s NVG-291-R Demonstrates Significant Functional Recovery in DoD-Sponsored Preclinical Models of Traumatic Hearing Loss

    Hey! Is this my birthday, Christmas, or what? I never thought they would arrive in the height of summertime! Before and after my first encounter with tinnitus, I was pretty much in perfect health. That made me believe there must be some simple cause, like a tiny screw loose in my ear that just...
  15. J

    Repeated Bilateral Transcranial Direct Current Stimulation over Auditory Cortex for Tinnitus

    Much appreciation and applause for the time and patient effort devoted to this examination. And no fault with the firm involved. They were quite upfront, but rather expensive.
  16. J

    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    Duh… can we conclude that Enbrel causes tinnitus, then? I’d say there must have been other factors involved as well. For example, prolonged negative stress, loud noise, infection, or age, which are the usual causes. Or maybe I should be more patient with the pharmaceutical sector, since they...
  17. J

    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    Well, in France, during August, the whole country goes on vacation?
  18. J

    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    Interesting point. The drug is targeted at those with blast-induced tinnitus. It seems that army veterans would be the ones most likely to need treatment for this. Florida has no shortage of army bases, so did he advertise properly in the areas near them, as well as in veterans’ hospitals?
  19. J

    AdventHealth Research Institute Offers Phase II Clinical Trial of Etanercept for Treatment of Blast-Induced Tinnitus

    Early-onset patients in the acute phase of tinnitus are often driven by the fear that if they don’t cure it quickly, it will become chronic and permanent. But if you’re already a chronic case, I suppose it’s only natural to weigh things up and think, “If there’s a risk of it getting much worse...
  20. J

    New University of Michigan Tinnitus Discovery — Signal Timing

    I hope that Professor Shore is strong, healthy, and enjoying her retirement. Duh… what was that story about Fermat’s Last Theorem? :unsure:
  21. J

    Cilcare's CIL001 Targets Cochlear Synaptopathy — An American/French Collaboration

    Really good video, but many of us cannot listen to the sound due to Hyperacusis. I wonder if there is a transcript that covers the basics. The subtitles are too small and move too quickly. Maybe I should get a magnifying glass. It is great to hear that something else is on the way. If Auricle...
  22. J

    New University of Michigan Tinnitus Discovery — Signal Timing

    How I wish I had paid more attention during my statistics course back then. I can clearly recall a unique occasion when human trials were interrupted, and the medication was approved early. That was during the AIDS epidemic, and the reasoning was straightforward. The drug had passed both animal...
  23. J

    The Trump Administration Canceled a Hearing Loss Researcher's Grant

    To my dismay (or perhaps excited outrage), my summary was not clear enough. The researcher in question was born nearly completely deaf, yet excelled in school and eventually earned a doctorate in biology or physics. His primary interest was the effect of magnetism on cells, and he applied to...
  24. J

    The Trump Administration Canceled a Hearing Loss Researcher's Grant

    A researcher with hearing loss got a grant to study restoring hearing. The Trump administration canceled it because of DEI Meg Tirrell ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The heading says it all, really: the struggle over research grants. In this...
  25. J

    New University of Michigan Tinnitus Discovery — Signal Timing

    I realize that I’m out of my depth here, but if it were possible to place the subject—whether human or animal—under stress while simultaneously observing the rate of cerebral blood flow to specific areas of the brain, could that provide more clarity on the overall picture? It probably would not...
  26. J

    Worsening Tinnitus Due to Orgasm

    It could be that you are wrong or right. There is no way of telling unless the writer is tracked down. I know of a somewhat amusing true story about a patient whose 24/7/365 tinnitus was accentuated when climaxing with his girlfriend. At least, the “intrusion factor” was intensified by the...
  27. J

    Suicidal Two Months After Tinnitus Onset from a Child's Scream

    This is a really thorny issue, and I wish the experts could come together and show us the right direction to take. The conventional thinking among therapists is to get used to what they call normal noise. But may I ask, what is normal? The duration of the noise is also important, as is the...
  28. J

    Studies Confirm Tinnitus Improves Over Time

    I hate to rain on your parade, but you might be making a judgment too soon. While it’s true that many people learn to habituate to their tinnitus, in my case it only began to improve slightly after one year. Even then, it was still a major bother. I tried Tinnitus Retraining Therapy when it...
  29. J

    Rinri Therapeutics

    This might be a bit obscure, or it might make for good reading. Who knows? The folks at Rinri might even find it useful. It is neat and interesting, but to be honest, I could hardly identify a cell even if it were inside a prison. So I will leave this one to the heavyweights...
  30. J

    Research's Attempt to Objectively Assess Tinnitus

    It is fascinating if scientists are truly homing in on how tinnitus is generated on the brain side of things. If we combine this with the new methods of scanning the cochlea, perhaps we will finally begin to understand the nature of the beast from both the brain side and the ear side. I have...
  31. J

    Mid-Infrared Photons Alleviate Tinnitus by Activating the KCNQ2 Channel in the Auditory Cortex

    Back in the 1990s, when I was younger and had more energy, I tried this therapy myself: a low-level laser directed at my inner ear from behind. It was combined with an injection of Ginkgo biloba (I hope I am spelling that correctly), and I had to breathe in pure or nearly pure oxygen through a...
  32. J

    Zinc Pills Stopped My Tinnitus :)

    Well, it is great to hear about some success. Zinc might be something to take when you experience a tinnitus spike, to help you get through the worst of it. It certainly deserves further research.
  33. J

    Auditory Nerve Section

    It is a disgrace for the research community that this is still being discussed and questioned. I suppose they will have to go back to severing hearing nerves just to prove a point—though this time, making sure the data is accurate. Of course, I am not volunteering myself. And how should the...
  34. J

    ATP-Gated P2x7 Receptors Express at Type II Auditory Nerves and Required for Efferent Hearing Control and Noise Protection

    @StoneInFocus, I must apologize. I let my feelings get the better of me. A wave of gloom came over me when I added everything up and concluded that, whatever promising research is making progress today, it will probably reach the market in ten years—by which time rheumatism or arthritis may have...
  35. J

    AudioCure AC102 to Treat Hearing loss and Tinnitus

    Therapies targeting recent-onset cases are where most of the successes seem to cluster. (Mind you, I have submitted my patented cure for recent-onset tinnitus — 100 percent natural — breadcrumbs! But don’t tell anyone. 😎) It makes you wonder about the connection between psychology and...
  36. J

    ATP-Gated P2x7 Receptors Express at Type II Auditory Nerves and Required for Efferent Hearing Control and Noise Protection

    Go on! Silver-tongued, pseudo-academic, raising our hopes… But if you are actually onto something, that would be wonderful. So, where is the catch? Does it only work for early-onset cases who happen to be billionaires? 😟
  37. J

    Excitotoxicity: New Class of Fibers Could Explain Tinnitus

    Just me surmising again, so perhaps it’s nonsense. Starting with the first ten words of the quote: “The development of an effective therapy for tinnitus and hyperacusis…” First, the patient presents to the ENT with subjective tinnitus. After being checked for earwax blockage and tumors, they...
  38. J

    Stanford Initiative to Cure Hearing Loss Now Lists Tinnitus

    I read one of the reports from your link, and it provides a good overview of the direction audiology research has been taking. It highlights how the field of knowledge is evolving and emphasizes that there are still significant gaps that need to be filled. For example, one research team might...
  39. J

    New University of Michigan Tinnitus Discovery — Signal Timing

    Here I am, extrapolating on something I only half understand. But if I recall correctly, Lenire is a combination of sound therapy and a device that “tickles your tongue.” To be a bit fairer, it also involves guided counselling, which in the early stages of tinnitus can be quite important. From...
  40. J

    Am I the Unluckiest Person on Earth When It Comes to Tinnitus? My 6-Year Tinnitus Nightmare: How One Festival Changed My Life

    Nice summary, @trevl, and it matches my experience as well. That said, we still do not know the full story of what is going on. There could be tinnitus, and then there could be tinnitus. What I mean is that the auditory system is incredibly complex. Of course, noise-induced tinnitus is...
  41. J

    Am I the Unluckiest Person on Earth When It Comes to Tinnitus? My 6-Year Tinnitus Nightmare: How One Festival Changed My Life

    Sorry to hear that you are in such a position, @Kam75. It feels like the world has gone mad. Just last summer, my landlord gave me notice to leave after seven and a half years. With the way things are going, it has become very difficult to find a place to rent. It seems like there is a new...
  42. J

    New University of Michigan Tinnitus Discovery — Signal Timing

    Now all Lenire needs is to introduce an after-sales follow-up, a heavy-duty persuasion session to convince the patient that their tinnitus has been cured. Like, no one can hear it... it is all in the mind. Just kidding. That said, I must confess that I benefited from TRT treatment back in the...
  43. J

    University of Pennsylvania: Advances and Perspectives in Auditory Neuroscience (APAN) 2025 Meeting

    Tinnitus and hyperacusis patients have much in common with the deaf and hard of hearing. So it makes sense to network with one another when it comes to research, rehabilitation, and therapy, even if some of the treatments might be considered outliers. I recently came across a photo of research...
  44. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    Well, if you do end up “joining the club” of chronic tinnitus sufferers — and note, you still have roughly until October 2026 (two years from onset) for your tinnitus to ease off or at least improve — so don’t give up hope yet. In my case, during the early stages, I was running around like a...
  45. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    Just a suggestion: try getting out into the sunshine, away from the sounds of traffic and city noise. The sounds of the river, birds, and wind can be calming. At the very least, you might enjoy the time spent there. Of course, how you manage that with trucks and cars driving and honking right...
  46. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    I see that you joined in late January 2025, so I conclude that your tinnitus onset was sometime in January 2025, about five months ago. You are still in the acute (early onset) phase. Your chances of it getting better are pretty good. It would be helpful to have a good ENT who understands...
  47. J

    Stanford Initiative to Cure Hearing Loss Now Lists Tinnitus

    Glow-in-the-dark axolotls reveal a clue in the mystery of limb regeneration To cheer you up and divert your attention from tinnitus: a) It is all about retinoic acid! Now why did I not think of that! b) Humanity has been evolving in the wrong direction. We should reverse course and develop...
  48. J

    Injectable Polyplex-Loaded Glycol Chitosan Thermogel for Efficient and Safe Inner Ear Gene Delivery

    Well, as I have said before, it is never too late. Fire up the motors and inject the substance again. See if it works this time.
  49. J

    Hi Kam75, I'm shocking ignorant about computers. I think you added a lot to the dialogue with...

    Hi Kam75, I'm shocking ignorant about computers. I think you added a lot to the dialogue with JoeCync... could you explain to me what "following you" means? Sorry that I'm so ignorant. Vive la France joeseph Stope
  50. J

    Injectable Polyplex-Loaded Glycol Chitosan Thermogel for Efficient and Safe Inner Ear Gene Delivery

    Maybe we should view it all like a football match. We all want our team to win the World Cup, but it takes a few years to train a good team. With diligence, hard work, and a good trainer, a team eventually develops that can coordinate things well. At some point along the way, we may even get a...
  51. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    What is the name of that movie again? One Flew Over the Cuckoo’s Nest! That is it. Of course, that movie was about the inmates living locked up on the funny farm. There is nothing crazy about us, right, Napoleon? Ha! Just kidding, @Tom Cnyc. But let me say that you are one very lucky person...
  52. J

    Injectable Polyplex-Loaded Glycol Chitosan Thermogel for Efficient and Safe Inner Ear Gene Delivery

    Progress, progress! Now we can deliver the goods to the correct address. The only thing left to do is produce the right goods. :popcorndrink:
  53. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    First of all, I want to say a big thank you for taking the time, making the effort, and having the patience to share your story and clarify the parts that were difficult to understand. Hang in there—or maybe I should say hang in here. As long as it does not push you out of the “sweet spot” of...
  54. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    Jehoshaphat! The medics should examine two individuals in depth: @Kam75, who exposed himself to moderately loud social gatherings. As a result, his tinnitus and hyperacusis worsened significantly—to the point of becoming almost unbearable. @Tom Cnyc, who did much the same but to an even...
  55. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    Duh… me again. I was shooed out of the library yesterday while I was in the middle of delivering my saga on one of the computers. That might have been a good thing, though, as it gave me a day to mull everything over. And really, when I think about the entire ongoing tinnitus experience in...
  56. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    So sorry to see you in this state. Maybe my experience can shed some light on the situation, but above all, you should find a good ENT or audiologist with experience in treating tinnitus and hyperacusis. There must be someone in Paris. Perhaps Frédéric, the super intelligent red haired guy who...
  57. J

    Tinnitus Drug Pipeline Market: Transforming Treatment Landscape for Millions Worldwide

    I’m starting to lean toward the idea that perhaps the solution to the tinnitus problem lies in solving the hearing loss problem. A more holistic approach might be the key. So how do you learn to jump two meters? Simple — just learn to jump four meters, and two will be easy. 🙄
  58. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    I’ve been mulling this dialogue over in my mind. Some patients benefit enormously from getting on with life and can handle loud environmental noises without much difficulty. Others, especially those with reactive tinnitus, may do fine until something like an ambulance passes by with its siren...
  59. J

    I'm Fine — Tinnitus Is Basically Not a Thing Anymore

    You certainly present a strong argument. But let’s imagine you are giving advice or a talk to a group of people dealing with reactive tinnitus and hyperacusis: “Everyone, try to forget your tinnitus and get on with your life. That starts with ignoring the spikes that unpleasant sounds can...