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The most common TEAEs across all XEN1101 dose groups (n=211) were dizziness (n=52, 24.6%), somnolence (n=33, 15.6%), fatigue (n=23, 10.9%), and headache (n=21, 10.0%). Two TEAEs of urinary retention were reported in the active treatment groups, one of which required a dose reduction, and both...

Sorry to revive, but I am experiencing this as well. I have had high pitched tinnitus for almost a year, but the last few months I have been noticing this horrible low hum that gets worse as the day goes on. Feels like it is in the back of my head and I cannot tell which ear it is from. When I...

I believe OTO-313 was initially targeting acute tinnitus. Have not seen that with OTO-413.

This might've been answered, but how does one measure if tinnitus is from nerve damage?

Praying they move faster with these new trials lol.

Trying to understand the science around this. If someone has hearing loss around 5 kHz, but no hearing loss above that, would the drug still reach that 5 kHz level?

I wonder if this can be measured somehow with someone's tinnitus. Like would the change of tone/pitch/loudness differ?

Is there a timeframe for when OTO-413 can be used? It looks like they tested immediately after noise trauma and 7 days after.

I was interested in going in and asked some questions. I was told "one subject did experience some worsening of tinnitus which was categorized as mild, and another experienced some mild hearing loss, which then resolved 5 days after onset."

This could be a good thing, no? More reason for them to monitor the drug's effects (if positive).

Curious what a sound distortion is. During loud noises, my eardrum almost feels like it's going to rattle. Is this the same thing?

Looks like they added more clinics. There's one down the street from my location. Just wish they would allow bilateral tinnitus...

Interesting results. I wonder if any of these participants that had improvements in hearing had tinnitus as well.

Any idea when they would tell you if you got the real thing or not?

Anyone in the trial with bilateral tinnitus and not just unilateral? I mentioned this to the clinic and they said there is still an opportunity for me to get in the trial.

Appreciate the updates! I wonder if transitioning from a higher frequency to a hiss is part of a healing mechanism.

Is the idea here that if it improves hearing around 8 kHz, then there is a possibility it decreases tinnitus around that same frequency?

I'm thinking about contacting the site near me. How has your experience been so far?

Hmm, so people believe FX-322 is a failure for people with little to no hearing loss and high frequency tinnitus?

Hi all, I got tinnitus from a brief second of my headphones being on full blast for a phone call. The first few months were brutal as it was a constant high pitched frequency. I went to an ENT and audiologist and couldn't find anything out of the norm and I had no hearing loss. For the past...

I got noise-induced tinnitus in March of this year from my headphones being on blast for half a second. I emailed one of the locations regarding OTO-313 and they mentioned I would be a good candidate, but am a little concerned. Does anyone know if this gel makes your ear feel like there's...