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I'm excited about this because, if true, it's the only time any therapy has been able to target hair cells. If they establish a working vehicle,...
This is a fascinating thread. I'm deep-diving into a publication I read about the connection between temporomandibular disorders and...
It ruined my day mate. Mice seem to have life easy.
Not great news for LY3056480 and hearing regeneration therapy. I hope some of the other trials pull through. → A phase I/IIa safety and efficacy...
Cheers. Looks like I completely misread the ClinicalTrials page. I will do better next time.
I think we need an activism thread so US / UK / EU members can reach out to their political representative's with a templated letter, something...
They used a viral vector as their delivery mechanism to inner hair cells to change genomic code (gene editing) which restored hearing. The child...
I was just about to post this but you beat me to it. From Lilly's website: This is potentially the BIGGEST news for hearing research in human...
Many compounds we see in pharmaceuticals are research derived from natural compounds, and/or molecular structure modified to be more potent. I...
This is a good response to give. If it was snake oil, they'd claim it fixes everything. I like the degree of humility here.
Thanks for posting this! The data seems very good. There have been many companies that have failed in this space but, given the people behind...
Very interesting, but I can't see anything hearing loss related on Anida Pharma's website at all.
10 dB is a lot. 3 dB is the doubling of air pressure/sound.
STR001 reached Phase III. If efficacy and endpoints weren't met, they'd have pulled the trial in Phase II. It would be nice if anyone from the...
Me too. Phase 2 will prove if their models translate to humans. However, after reading some the literature I'm skeptical as AC102 seems to just be...
The trials are limited to those with SSNHL that occurred less than 120 hours ago. I still don't know how this compound works. Phase 2 is trying to...
Recruitment of Sudden Hearing Loss Patients for Clinical Trial: Novel Compound AC102 Outperforms Corticosteroids Preclinically AudioCure Pharma...
Spiral Therapeutics' drug delivery system to the cochlea which lasts a controllable time, in my opinion, will be one of the biggest breakthroughs...
I've been following this and other research news for some time and, like others, I am disappointed. Just some thoughts on this for whatever it's...
Thanks for the article. It seems interesting. I was diagnosed in early 2010 and had a Stapedectomy in 2014. I've had frequent follow-ups since I...
I recently started taking Risedronate 35 mg weekly. It's been around 8 weeks since I began. I believe it has helped calm my tinnitus somewhat. It...
These two steroids can be a saviour for people with sudden hearing loss. However, I believe taking them just because you have tinnitus is a bad...
It's in the exclusion list for very good reason, 1) so to not complicate the trials, 2) the drug will ultimately be licensed for a specific use,...
Do you remember how you acquired the hearing loss apart from the headphones? Does hearing loss run in the family at all? Instead of...
It's been wild, just keep our minds and bodies healthy for one day when there's a golden cure we'll have the rest of our health to enjoy it with
There's evidence Ebselen is a potent anti-osteoporosis agent. Cochlear otosclerosis is the demineralization of the cochlear bone and bony...
Thanks for posting this. I've looked at the literature and it seems extremely interesting. It could possibly even help with slowing cochlear...
@paul mclean, do you have any update on your progress with Zolendronate?
Yes. The research shows greater success in regenerating IHC in young mice I believe. However I think there are now some variations in the methods...
Well yes. Scientists / Researchers are focusing their efforts to supporting cells inside the Cochlear. OHC (Outer Hair Cells) support the Inner...
Good on you. I myself would love to participate in curing my own T and Otosclerosis using non-surgical methods.
I've been reading "In 10 Years" often for many projects. The goal for some of these initiatives is to set-up some short to long term funding, I...
Looks like trials have already started!...
Deafness is broad. This news is exciting and I have every hope something positive comes out of it and other work like it by other researchers and...
[MEDIA] Two members of HHF's Hearing Restoration Project (HRP) discuss how a chicken can help us understand how to a cure for hearing loss and...
Stanford researchers have received Bio-X funding to develop a tiny moving probe to study the mechanical properties of sensory cells in the ear....
Finally. A crowd sourced project to treat an ear related defect! Have been hoping to see or start something like this for a while. I hope this...
MELBOURNE researchers are creating tiny particles to deliver drugs to the hard-to-reach inner ear, aiming to create the first preventive treatment...
After reading how MIT are researching the use of nanotechnology and bone-repair surgery. I began searching to see if I could find any papers or...
I like HHR foundations approach to hearing loss and tinnitus. Make it sexy as the stigma surrounding it seems to be - "it only occurs at old age"....
[ATTACH] The 10 Year plan to understand some of the blocks in place preventing inner hair cells from regenerating by themselves.
Excellent . Thanks for posting that clip, I don't think I have come across it. It would be nice to know if Dr Andrew K. Groves has made any...
A well informed individual is capable of knowing the obligation that exists between the stakeholder and shareholder. I have no interest in...
Stem cells could work, useful for areas in the body where normal regeneration is impossible. Stem cells could be some distance away with the...
I often come across articles highlighting this. Last I read, over 40% of veterans came back with some types of hearing related problem, majority...
You have overlooked that this industry may want to continue or "survive" the next 5-10 years - just like any other. If IHC cell regeneration was...
The Genetics of Hair Cell Development and Regeneration Andrew K. Groves,1,2 Kaidi D. Zhang,3 and Donna M. Fekete3,4 / (Volume publication date...
Here is a lecture done in 2011 - Touches on hair cell regeneration. [media]
On the contrary, research has been done on smaller mammals (mice) to regrow inner hair cells (IHC's) with some success. Shortly after researchers...
Notch signalling pathway inhibitor [media]
I believe this is the case. Stretched funding. The longer these people have jobs.
In relation to Inner ear hair cell regeneration specifically Targeted Delivery Methods: - Nanotechnology Using nano drug delivery to the...
Thank you for this, was just about to post a thread on all the recent findings on this topic.
I would love some second opinions on this. I have been suffering from Tinnitus and Hearing loss for almost a year now. My Tinnitus affects my left...