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My understanding is it would reach 5 kHz and frequencies above. You have hearing loss above 5 kHz. You may not realize you have hearing loss...

Fair enough. It's just my view that the commenters can view different companies maybe not equivalently. I'm specially talking about all the love...

I disagree with that assessment. Talking the talk would be more like promoting their product to investors and never testing it. Frequency...

Sorry if I missed this but did Frequency release a before and after test subject audiograms for the 8 kHz-20 kHz range? Personally, I'd love to...

So if the trial recommended limitations translates to the designed population, this device doesn't make sense. The device isn't going to improve...

This is a result of the brain being so complicated that science still has a limited understanding of its underlining processes. This doesn't worry...

Unless there have been updates on imaging you'd have to go through dissection of the ear preferably during an autopsy. FMRI techniques might...

Thanks. Yea I get that NDMA isn't regenerating anything but I'm curious if someone could have some connected synapses that have no/reduced...

Has it been proven that there is no underlying structural improvement with this treatment, even very slight minor repair.

Can someone remind me their current plan/timeline assuming a successful Phase 2a. Will they go to a Phase 2 or 3? When would that next Phase...

More like: Susan Shore (5 years from now): "Our Phase 2 trial has been delayed 2 more years because (insert made-up irrelevant and vague excuse...

Can someone summarize what we know about OTO-6XX?

ENTs solve problems??? Could have fooled me. That statement is mostly true, I get that on rare occasions they will surgically remove tumors.

Yea agree. The minutes response more between their own employees. The main point is that even though they aren't in the lab all employees need to...

There is absolutely no excuse for not drafting a paper on the results due to the coronavirus. With the stay at home order they should be posting...

Regardless of hearing protection it is too risky for your ears to shoot a firearm ever again throughout your life. The only caveat would be if you...

You meant kHz right?

@Tweedleman Nah take handfuls. Just bench a ton to prevent man-boobs.

This company's management were dogshit con-artists from the start. F them and their former sleaze-bag CEO for wasting all that investor money.

Acknowledging that all life eventually has an endpoint is not cruel it is simply self-aware. No one is immortal. Understanding that fact is part...

That's not a given. Have you heard of Enron? Also investor dollars toward this company could be less money going to others in the regenerative...

That's a question for us but not a showstopper for the company. If they've improved your hearing and that improvement remains then you've got...

True but for this company their priorities are designing an aesthetically pleasing work space and raising money from investors via fanciful sales...

Right but is PIPE-505 dividing the supporting cells?

That's the answer I was afraid of.

Would treatment with this product limit the effectiveness the future use of Frequency's FX-322 product. Aka does the increase in ATOH expression...

One what does it matter if Freq is not yet approved by FDA but approved in Euro or Asia. It would be available somewhere where a person could...

I hadn't heard that noise produces a chain reaction which results in DNA mutation. Has this been confirmed elsewhere. How does this exactly work?...

Did any of these 15 people measure above 8 kHz? If not through Frequency Therapeutics, then independently on their own? If so what happened...

We don't necessarily need imagining technology although that would be very helpful. All the study would need to do is apply the compound to one...

If you don't mind me asking, what is your dBa loss at 8-16 kHz?

That's probably not what they fear. What they are likely worried about is the objectiveness of tinnitus patients. Since there is not yet a way to...

It's not testing on me I'm worried about, it's all the other people who will be turned away and the resulting lack of data/information that will...

It sucks that tinnitus is an exclusion for their clinical trial.

Please stop commenting on this thread. Whether or not timing is effective no device will ever be made from this "Work". We should all move our...

Is it just me or did Decibel Therapeutics go backwards? This company is a waste. They have incorrect priorities. At this point I only hope they...

Doctors who preform CI surgeries have first hand knowledge of the ear. So I wouldn't immediately discount their information, especially if it...

Just move to LA, SF, or NYC to buy one so you can sit in it in gridlock :D

Not really if certain parts of the day are more important than others

What frequency do you have 20 dB and 40 dB losses at?

@Roadglide I'm assuming you get to keep the wires attached after the study is complete or do they require that the hardware be remove?

Understood. Still even if the people in the studies all had hearing loss below 8 kHz it would be useful if Frequency measured the before and after...

This is the one near term thing Otonomy is doing that I'm very interested in learning the results. Honestly people on this site should be a lot...

Very well then the "University system" does not work full stop.

While I understand them not talking to the avg joe I just don't buy that they have been using time effectively. They have delay trials for years...

How far is that ABC station broadcasted? Just 30 miles from Boston or does it cover all of New England?

Any speculation on the cause of the move??

If anyone knows the reason for this date slippage please post to the community!!!

It's not just your hope that is concerning; with their glacial pace of development I could see a Chapter 7 for this company on the horizon.

https://www.decibeltx.com/pipeline/ Their pipeline confirmed what I had been saying "that they are wasting too much time on ototoxity therapies...

Why you might think that's the best approach the term treatment is being misappropriated. That approach is best characterized as a behavior...

Yea I kinda mentally gave up on this when I learned they started pre-clinical prior to 2013

Oh. Yeah I had already written OTO-313 off as useless for long term Tinnitus. Very interested in the results of OTO-413 though.

Explain why this matters?

Did your hearing get affected by the hole/healing/scar tissue? Any additional high frequency hearing loss due to the injection?

Even if FX-322 works creating new hair cells and neurons; no person is going say they don't want repairs and addition neurons to legacy haircells...

If used properly it's an indicator of hearing loss when compared to the predicted high frequency hearing of the patient's age cohort. That...

Are you sure on that timeframe? Any reason they couldn't start phase 1 in say 5-7 years??

Is the ERBB2 a novel pathway from Frequency's drug trial? Who/when is testing the "two drugs, originally developed to stimulate stem cell...

None of these delays surprise me with U-Mich. They have been unreasonably slow given they started work in the early 2010s. Don't worry too much if...