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So it looks like there are other places working on developing drugs to regenerate synapses, other than Otonomy and Pipeline Therapeutics. I guess...
Simple. You just regenerate the cochlea, the brain will then take care of rewiring itself. It's just like if you close your eyes and don't have...
The difference is synapses are more vulnerable and take the brunt of the damage. @OptimusPrimed is spot on, that is the primary underlying cause...
OTO-413 doesn't work by repairing hair cells. It works by regenerating cochlear synapses.
Looks like we're getting the news from everything, Pipeline Therapeutics, Otonomy, and Frequency Therapeutics in mid 2022.
Yes please do. Pipeline Therapeutics' drug and OTO-413 are our best two shots right now.
That's not right, no. Tinnitus is usually from damage to hearing, so having a drug that can regenerate the damage would treat the underlying cause...
Yes but very rare, most of the people on this forum have tinnitus from loud sound exposure, which is most treatable by regenerative therapies such...
I disagree, we already know the overwhelming majority of cases of hyperacusis and tinnitus are caused by external insults especially acoustic...
It doesn't matter what the target audience is. Reversing tinnitus would be an incidental effect to the main purpose of regenerating synapses to...
It'd be nice if someone was able to get ahold of a Pipeline rep or employee to find out when we're getting any kind of results from the trial....
So is the consensus that the synapses remain viable for regeneration for decades in humans so we'll be able to benefit from PIPE-505 or OTO-413...
"The repurposing of bisphosphonates shows promise in animal models for treating hidden hearing loss. At the present time, these drugs are not fit...
If I recall, during testing on mice, they were able to quite effectively regenerate the mice' cochlear hair cells with FX-322. So we know at least...
I don't see how Neuralink can be of benefit if it doesn't have any capacity of regenerating the cochlea. Neither cochear synapses nor hair cells....
That's probably because these people had extremely mild damage to their cochlea such that tinnitus only appeared after prolonged periods of...
See this is were I somewhat differ. I think we've all waited long enough and we want a regenerative therapy that will restore clarity perception,...
Yes of course. Assuming you have for example noise-induced hearing loss then regenerating the damaged synapses and/or hair cells would reverse the...
Because the regenerative treatments treat the underlying source of tinnitus which is most commonly damage to cochlear synapses, and sometimes from...
But OTO-313 doesn't do anything to restore hearing. It's like treating the symptoms but not the underlying problem. Even if it did get rid of...
Exactly, OTO-313 is useless for tinnitus because it is not a regenerative drug. Otonomy's only promising drug is OTO-413 because that actually was...
According to the latest research it is not so much the destruction of sound receptor hair cells, rather it is damage to cochlear synapses (which...
