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That gene therapy is for vision. They use that example to suggest that when gene therapy for hearing restoration becomes available, it may not...

This is an interesting read: Fusing Biology with the Bionic Ear

Hearing loss and dementia. Two human conditions where you'd think that just a leeetle bit of government financing and proactivity could do a huge...

At least some of the IP was conditionally licensed to Frequency Therapeutics by MIT. It may possibly revert to them. I don't know. In this case,...

I don't think so. I think he was suffering. Paranoia and aggression was part of how he responded. You know, thinking about it, I agree with you.

Going in for my cochlear implant evaluation in about 3 hours. I understand that voices sound more natural within days/weeks/months. Highly variable.

If you were going to put forward a cautionary view back in the day, first you had to get past @JohnAdams. He reacted aggressively to any...

The womb is a very noisy place actually.

@Tau, didn't they do a trial (in Germany?) that determined that the drug did reach the site of action? It was a weird way of putting it. It was...

Both. I can just function in quiet with hearing aids. I can't function in noise at all. I've got every reason to at least get evaluated but I'm...

Close to profound at the higher frequencies. There's been a big drop off from 1 kHz up over the last few years, so heading south inexorably. Word...

I saw an audiologist back in December who told me that a cochlear implant might be the next step for me. There are lots of things you can have...

It makes me wonder whether FX-345 was just there to project the idea that they had other options. FX-322 was going nowhere. Bring on the...

So, no-one feeling a little angry at this point? Feeling that they've been led down the garden path by one of the greatest hype machines the world...

Feeling for all of you who invested so much hope. Cochlear implant for me I think. All the best.

I think the original IP that they started the company with is actually licensed to them by MIT. Any subsequent IP would be sold to someone else....

Who are they pitching to? Only possible answer: the stock market. They want to maintain the value of their individual stock holdings. Personally,...

Sorry, I haven't got a source at hand. I'm sure one of the Frequency Therapeutics fans will. It was discussed ad nauseam in the Frequency...

One of Frequency Therapeutics's selling points was that it would supposedly not deplete the support cells. Once a support cell divides, one of the...

The previous results still stand though? “In light of challenging financing environment, we intend to explore strategic options to advance and...

Sounds nuts to me quite honestly. Statistically significant says simply that there is an effect - possibly minuscule. It doesn't say that the...

Cynical viewpoint: If they abandoned FX-322, the share price would tank again and they're all heavily invested. Or maybe they really believe what...

One of the things that is sometimes recommended to maximise your speech understanding is to learn a musical instrument. Otonomy might feel that...

Fasting and/or calorie restriction is believed to reduce inflammation. Inflammation is believed to affect tinnitus. Neuroinflammation and Tinnitus

I came across an article on autophagy that prompted me to try time controlled eating. I'm fasting between 8 pm and 10 am. Stronger individuals...

I think you're winning.

And the good news just keeps on coming.

They're taking a hearing loss treatment to the FDA, not a tinnitus treatment. Any improvement in tinnitus would be a flow-on result of improvement...

Answered in the post above yours. It's about getting a clean result in a clinical trial. It's not about equity.

It's hard to let go of though, isn't it. Like here I still am on page 636.

I think we know what you meant to say.

Look up 2 posts from yours :rolleyes:

It won't. Ninety percent of this thread is pure speculation based on almost nothing. My comment was mostly meant as tongue-in-cheek. But...

If your grandma was unable to have children she couldn't be your grandma? Maybe I'm missing something... Anyway, did anyone else notice that...

There's a bit of a problem with your analogy

It's a silly thing to be arguing over really but anyone who's been here for a long time can remember people being stomped on for being too...

Let's see. There's everything Frequency Therapeutics ever said until about a year ago.

Who would have thunk it? Hough Ear Institute has been discovered by Dr. Cliff. [MEDIA]

This whole thing feels like someone's part-time project. I think with the lack of urgency you'd have to assume that the results have been...

I think they are pretty much. They're both going for improved clarity. Frequency Therapeutics haven't talked about improving thresholds for a long...

Commences September 2022.

Pure bullshit spin. Nine people achieved statistically significant improvements at some point in the trial! Pity that at least four of them fell...

Easy Tiger. Just sit over there and eat some of that other cake with no medication baked into it whatsoever.

They should call Lucchino for advice. :confused:

Pity we're a bit of a niche market. Otherwise that could go viral. It's kind of close to how I imagine it all went down.

Reading between the lines, they couldn't shift hearing thresholds either. Like Frequency Therapeutics, they're going for clarity.

At least they never shouted from the rooftops that they were god's gift to the hearing impaired. Unlike another outfit that begins with the letter F.

When the topic of auditory training has come up in other places a common response has been you'd be better off doing formal musical training. A...

Formal musical training is believed by some to improve speech understanding. Google 'auditory training'.

I don't care about the numbers particularly but I do care about being able to hear sounds again that I no longer can. That includes soft talkers...

Yes, they're kidding you.

It's like a grieving process that's playing out. People are still trying to process the loss of something of great importance to them. While...

...again.

I was hoping for both but I broadly agree with you. It was such a smooth change of emphasis we pretty much all bought it. I was hoping to throw...

I'm still skimming through this topic. Not sure why any more. Kudos to the three main contributors that remain. I found a recent review of the...

I think it's hard to be impartial whether you own stock or not. I kind of would prefer if people took their discussions about the stock somewhere...

What gives me a little bit of hope is the follow-up study they did on those super-responders. And the thing that gives me hope is the way most of...

I think it's probably the end of the line for FX-322 (a sliver of hope remaining) but not necessarily the end for Frequency Therapeutics. They are...

Maybe they burned themselves. They added some 'soft' criteria to increase their chances of getting a good result. If they had stuck to the...

Something that needs to be said I think... No-one in this group (including @nightowl) is responsible for the results of this trial. Frequency...