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I hope it‘s seriously news: Some Deaf Children in China Can Hear After Gene Treatment

Some new findings from University of Virginia: UVA Scientists Discover Repair Process That Fixes Damaged Hearing Cells (virginia.edu)

I, like many others here, was completely torn away from life. My life was music, I was a musician too. After my first sudden hearing loss with...

I couldn't find any information about it. It’s in the pre-clinical stage, so there is a very long way to go.

Hi XiviaN, I am sorry to read that you are suffering so much because of your tinnitus. I can empathize with you very well. In the last 20 years,...

Unfortunately, I cannot yet speak of an improvement, at least not a lasting one. Yesterday, the tinnitus was very much in the background, but...

True, after the failed trials from Frequency Therapeutics, Otonomy. Audion, Novartis (GenVec), it's all very discouraging. The work of researcher...

Hmm, I just read this in the following article: Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in...

It would be interesting if regenerating new hair cells was really possible by just manipulating the ERBB2 gene. I hope they will publish more...

It's a little bit confusing, but the "regeneration injection AOK-1" seems to be the one Hough Ear Institute licensed last year for further...

Is a treatment like this offered somewhere?

Hi, I protect my ears always when I‘m in a loud environment. Last week I was at a concert fitted with very good earplugs. But I got a spike...

The aim is the same, regenerate hair cells responsible for hearing, but a very different approach, I guess more complicated to apply than FX-322.

I really don‘t get Hough Ear Institute. They have talked about their "blast" pill for decades, but nothing has really come out of it. On the...

And all this "just" for a protective pill. How much their regenerative program would cost?

There is new information about the development of NHPN-1010: NHPN-1010 Clinical Development (houghear.org)

A big update about this research: Scientists Regenerate Hair Cells that Enable Hearing

I have been following developments in the field of hearing restoration for 20 years. Compared to 2003, a lot has happened in this field. I am...

But it's understandable that, for many of us, it provided some hope at least. Now, we definitely know.

Nothing specific, but there is more research going on out there. I know, everything is years away, but still going on.

Very bad to read about this, but we must face the facts. Frequency Therapeutics already removed everything about "hearing" from their website....

One more company with a hearing loss product in the pipeline: Pipeline - Myrtelle, Inc. (myrtellegtx.com)

Oh wow, that is also a nice finding. Many of the top researchers in the field will attend. It would be very amazing if they could turn back the...

It‘s planned for second half of Q1, so probably March.

I found this very exciting read from the top notch researcher Zheng-Yi-Chen about his advanced work in the Chen Lab: Five Questions with Zheng-Yi...

Hi Ryan, Did your spike get better? I'm in a horrible one right now, just because I forgot my wax ear plug and took some crap to fill my ears.

I just hope they can reach their goals with FX-322. I'm wondering why they didn't go straight with FX-345 with its probably better delivery...

OK, so I was wrong.

I'm really not sure anymore but I thought OTO-6XX was licensed from Quark Pharmaceuticals. They had some hair cell regeneration preclinical...

FREQ stock dropped almost 10% today. What does that mean?

Are there any news of SPI-5557? It looks like it has not made any progress. EDIT: This is an interesting read retrospectively because the...

Hi. When did your ear problems start? I had it very bad and maybe the same thoughts as you have today but I can tell you, things will get better...

An MHH research team has identified the molecular switch for the formation of inner and outer hair cells and thus found an important building...

If they could show positive results with FX-322, that would be great. This year is my 20 anniversary of my first sudden hearing loss in 2003....

If there is proof of regeneration, that would be fantastic and the first time in a human cochlea. I really pray for some positive results from...

If there was good data and FDA allowed them to market their drug, I guess shares would increase significantly, because it would be the first drug...

Cool, I live about 200 km south of Tübingen, in Switzerland. Please let me know what they answer. Thanks.

Acousia Therapeutics (Böhringer Ingelheim) They seem to be entering clinical trials soon. They claim that their compound does regenerate,...

Don't blame yourself too much for your investment, it really looked so promising for many of us. I just didn't invest, because I was too lazy to...

Agree, unfortunately, it‘s far away from a robust regenerative effect. It is hard to accept after years of hope. Others will try their...

He is doing research on how to regenerate hair cells. Of course he doesn't have the holy grail in his hand, but I guess he might understand more...

After Phase 1 results were released, I discussed it with a top notch hair cell regeneration scientist. He wasn‘t that excited about, maybe to keep...

Today is the day we are back to zero in a quest of a hearing loss treatment. If we look at the pipelines of companies working on hearing loss...

It‘s an exciting time for regenerative medicine for the inner ear. But as of today, we still have no insight what exactly happened with Novartis...

What do guys think is the reason, that people in the Phase 1/2 didn‘t get more than 10-15 dB improvement at 8 kHz? Does it mean that FX-322...

Is OTO-413 also meant to help people with long term hearing loss, or just acute?

Let's speculate that FX-322 gets FDA approval by 2025. How long would it take for Frequency Therapeutics to then make it available in the...

Correct, it's not a done deal. Even if it looks very promising, the possibility of failure is still there. Even several year delays are possible...

Enrollment of FX-322 Phase 2a Complete: Frequency Therapeutics Completes Enrollment of FX-322 Phase 2a Study for Sensorineural Hearing Loss

Maybe Otonomy would be open to the idea, since Otonomy was founded by Jay Lichter who has Meniere's & hearing loss with the aim to develop...

When we talk about drug delivery, this is a project I read about years ago. So anybody know if this device made it to the clinic?...

If FX-322 worked and helped, I wouldn't be afraid to repeat the procedure... that would be the least of my concerns. I have also read about 5-10...

Yes, he is a specialist @ Stanford. I guess it‘s normal that there are always other opinions, especially if the dataset leaves some space for...

FX-322 is injected into the middle ear, it enters the inner ear „liquid“ through the round window membrane. What is the reason that the whole...

Some new proteins identified for hair cell development: https://www.genengnews.com/news/protein-identified-for-new-hearing-hair-cell-development/

OK, so in Phase 2A participants are already given 4 shots and Frequency Therapeutics might already know about the improvements. I hope with 4...

So is Frequency Therapeutics allowed to change their formula of FX-322, let‘s say for a Phase 2b, or would this start again at Phase 1/2 if they...

I think it's important that professionals are openminded for solid research. But we shouldn't forget that we put a lot of hope in Frequency...

Hi, Same happened here, it really depends on the ENT. I used to visit a so-called tinnitus clinic. I also told them about some clinical trials...