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nope. i would say it did help me significantly with hyperacusis and habituation.
i think that the people that got VS from RTG should open a communication line with each other not just for support but to somehow figure out what...
hi everyone, i've been keeping tabs on this thread for some time now but haven't posted. i posted extensively in the retigabine thread a few years...
which nerve is he referring to? i'm guessing its the vagus nerve.
hang in there bud. there is a chance it goes away completely, but i guarantee you that your situation will get better. since you have...
its so hard to assess this very subjective phenomenon, particularly given the passage of time. given how great a part of the suffering was caused...
hi all, i have not been on the forum for awhile, just wanted to check in. as some of you may know i was one of the first trail-ees of the drug,...
ive been on the ketogenic diet for the last 4 months. i can't say if it helps or not for t (probably a little), but it definitely has eliminated...
i'd suggest trying some from a different source just to make sure. this drug is pretty intense, i don't see how any nervous system can escape from...
3 weeks. 300mg tid to 400mg tid was marginal improvements experientially, but i was pretty drugged so who knows. but 200mg tid to 300mg tid was a...
leon, i just read your user experience. is it possible you have an unreliable batch of pills? some have noted differences in pills they got online...
i didn't feel anything until 300mg TID. a 200 mg pill did nothing for me. i think you should wait till you get to a 300mg TID or 350mg TID to draw...
In Tzounopolous' recent HCN paper there is a section addressing the limitations of this model. I don't think the conclusion is that the model is...
400mg at one time is the optimal therapeutic dose for a short course. i stayed on that for three weeks, some people have stayed for less or more....
insufferable. not a single person on this thread has been playing doctor. everyone is simply providing their opinions, and on a good day some...
i did two courses of am-101 (the second had the real drug). i didn't note any drastic improvement (unlike RTG), and now going on 2 years later, i...
yes. i suppose people aren't responding because its quite a personal question. perhaps you would be better served PMing individual trial members....
Very good data research, thank you for that. Regarding the QT issue, it is not a big issue with RTG. If i recall correctly, it is Kv7.1 are the...
its possible that RTG has a much greater therapeutic potential in the acute stage, whatever your subjective level of t is. the same could be said...
looks good. i'd say also that if you are not feeling anything at 100mgx3 or 150mgx3, you can probably go up faster. once you have an effect, then...
Yes. Permanent effect on H, and a purification of the sound. Volume also decrease significantly.
nothing has been proven @nills. sorry it didn't help you but it has helped other people on this forum (including me). what i don't get is why...
anyone have any info on why EARS has jumped so high in the stock market?
i like the idea of a fast taper up. it's what Mpt did. you are trying to undo the pathogenic plasticity. i like zimicheal's analogy of 'busting...
hey there ateos. great points as always. my trial lasted roughly 8 weeks. i did a fast taper, i reached 300mg tid in about a week, and stayed...
are you feeling any side effects? i remember a few times taking RTG and not feeling anything, but that was rare. it's a pretty crude drug (not...
I didn't feel anything until i ingested a 300mg pill. 100mg truly is nothing, and once you are finished metabolizing it (8 hours), it is gone from...
does anyone know if auris will tell us if we got the placebo or not for the first trial? i would like to know. i took it in may 2014.
They definitely have some effect on the brain and may effect the t levels, but I doubt that it does so in a permanent fashion. I was wondering...
interesting. this is the first i've heard of cannabinoid receptors being the issue. the DCN is definitely ground zero for (most) tinnitus, but...
I think if you have the form of T which is a constant sound which never fluctuates, i don't think RTG will work. I am guessing that you may have...
i agree with needing to go to a high dose, but i think some people are tapering up way too slow. you want to undo the pathogenic plasticity, and...
also wanted to add that i have been on the ketogenic diet for the last 4 months, and i am quite sure that it is helping. the literature on that is...
use the search function and find my posts in this thread and the user experiences thread.
this is pretty incredible. anyone have any ideas about what might be going on here? at the very beginning of this thread, some people (@Zimichael...
while this is true, i am sure danny would tell you that the stark contrast between his T experience before and after intervention with RTG is...
this is a good synopsis, but I think the HCN channel involvement is pretty exciting. I found two quotes to be informative: "our results suggest...
for the two months that i took it, i was not able to do anything very complicated. thankfully it was a very slow two months at work, and i worked...
yes, i am a pretty big guy (was around 220 lb when i started). i didn't feel anything much until around 250mg three times a day. it really kicked...
this thread has degenerated. i think trobalt is a great idea, and dannyboy has done some work towards encouraging some others to try it out, but...
here is a recent update from Autifony.
here is a new document that a pretty good overview of the entire pipeline of Otonomy. Pages 5, 20, and 25 specifically relate to OTO-311.
update with me: t is still low, and is not much of an issue with me anymore. i don't notice it much, and when i do it doesn't bother me. good to...
i know of at least one person that went with a chinese pharmaceutical synthesizer (certified by the CFDA - chinese food and drug administration -...
i guess @dan 's statement was ambiguous, but i took it to mean he was inquiring about SF0034.
the correct answer is: No SF0034 showed >10 times higher IC50 values for hERG inhibion, which indicates that SF0034 is less likely than the...
@attheedgeofscience has requested that I post this relevant paper for him.
From the recent Tz paper on SF0034: "Although the mechanism by which retigabine generates toxicity to the skin and retina remains unknown, these...
this drug seems like you could take it and go about your day (hopefully with some appreciable effect on your T). trobalt made most tasks very...
also, that bit about it hERG is cool. hERG is a cardiac Kv channel, so this will eliminate whatever heart issues people had, although from my...
great work @attheedgeofscience!
@valeri it looks like given your constraints, what you want to accomplish is a sense of whether or not the drug will work for you. to that end i...
yes and yes. please read my user experiences. i am getting a lot of the same questions from people in my inbox. i have done a good job in this...
i'd say more than 6 months and you might be courting the possibilities of long term side effects. this drug has been prescribed and has been used...
its been 4 months since i stopped RTG and all my faculties are 100%. regarding the fast taper, honestly i think you will have side effects for the...
i agree with your doctor. stay the course. the side effects aren't that bad and i seriously doubt anything is wrong with your kidneys (maybe you...
Trobalt only works on Kv7 channels, it does not work on Kv3, or any other K channels. I only ever read one paper which briefly mentioned that it...
i agree, H and T are intertwined. I in fact did not know i had hyperacusis until i took RTG. I just though the pain I was experiencing was simply...
i would say we have had quite a lot of people that have started on this drug, but we have not heard from many of them. would anyone like to...
@Danny Boy, @Juan Carlos, and myself have had lasting improvements on 400mg, but I would say that you would need to go up to at least 300mg to...