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"The Phase 2a interim results also showed an unexpected apparent level of hearing benefit in the placebo group that did not occur in previous...

It is interesting that they are stating right after their IPO that "FX-322 designed to enable hearing in higher frequencies". If they mean that it...

That is a good question. There is still a share price stabilisation mechanism (overallotment) ongoing following the IPO so current price probably...

I am surprised that so little has been commented here about the valuation. IPO valuation reflects what the founders, investors and advisors...

I am not suggesting anything but just quoting a general definition of in vitro which is “happening outside the body in artificial conditions,...

That is called “in vitro” not “in vivo”. In vitro is performed in a test tube or elsewhere outside a living organism. In vivo is taking place in a...

It is proven to grow hair cells of living mice but not living humans. Pre-money valuation of USD 425 million is very attractive if you believe it...

You are convinced that having Astellas as an investor guarantees success in curing hearing loss :) You should definitely buy Frequency...

There was no change in audiogram so according to Occam’s razor the most obvious cause is something like bias. Bias is the intentional or...

After researching it for over 40 years you would think they have more than: “…may contribute to their speech comprehension and control”. It is...

Someone can check my math since I have not spent more than five minutes on this. 4 patients out of 15 treated with the drug got about 110%...

This is what it says in the IPO document: "The drug diffuses into the cochlea and is expected to create the greatest concentration of drug in the...

You can think yourself how much would you be prepared to pay for Frequency Therapeutics share in two scenarios: 1) Drug is safe, 2) Drug is safe...

The question is does Frequency Therapeutics truly believe in FX-322? The IPO value of the business would be at least 10 times higher after...

What you are essentially saying is that safety is far from confirmed.

I don't think it is negativity to be disappointed when a hearing loss drug has no impact on audiogram. Your reasoning is pretty much based on...

You are not convincing if you are suggesting that word score results were due to improved hearing in ultra high frequencies. Why are you denying...

Or maybe the Japanese quarter is 25 years and they have more time to wait than us here suffering of tinnitus and hearing loss. There is always...

You joined a discussion chain in which it was claimed that frequencies up to 16000 Hz are needed to distinguish words like bike, Mike, hike, etc....

It looks like you copied and pasted p-value definition from somewhere so I am still not sure you really understand it. Many statisticians view the...

You are suggesting that audiogram no longer is the standard method for measuring hearing loss. Extraordinary claims demand extraordinary proof....

Can you guess why Frequency Therapeutics completed the audiogram tests in the clinical study up to 8000 Hz and not up to 16000 Hz?

I am not missing anything. You did not not read what I just wrote. I only explained that there may be chance involved in word scores. You seem to...

I was showing ways how word scores may be unreliable especially when you have low sample size. Some patients may move faster on the learning curve...

This is what Wikipedia says about human speech frequency: “The voiced speech of a typical adult male will have a fundamental frequency from 85 to...

I am not sure exactly what kind of word score tests they used but I have completed them in the past and my experience is that there is a learning...

That is not statistically significant. Most of the patients didn't get any impact on any of the tested frequencies. I wanted them to succeed as...

You are correct and it is very strange that so many people here are in denial about it. Hearing loss drug that has no impact on audiogram does not...

Drug safety is dose-dependent. Think about for example paracetamol which is a safe pain killer with recommended doses but higher doses can cause...

What a terrible day this is really. This is a worst case scenario come true. For years people here have been begging that Frequency Therapeutics...

This is a major disappointment, there is no way around it. Majority got no improvement in audiogram and some got 10 dB which is far from curing...

It is not only about Frequency Therapeutics and their publications. Discussing tinnitus and hearing loss is very therapeutic and it is a...

If there is a will there's a way. We got nuclear submarines and a man on the moon... It is a question of resource allocation.

This is a bit off topic but it would be great to get similar imaging as above done on your own hearing hair cells. Does anyone know if that is...

Coordinating hundreds of scientists, tendering and negotiating a global out-licensing deal at the same time takes a lot of resources as well.

I hope that this new licensing deal, $80M USD new capital and Astellas' contribution adds sufficient resources for the development of FX-322....

So Astellas has global rights for development and commercialisation except for the US for which Frequency Therapeutics is responsible. I hope it...

Maybe you’re right, maybe not. Breakthrough designation has to be for life-threatening disease. It does not mean that the treatment itself is a...

So the breakthrough designation shortens the drug approval process in average about 3 years. I am wondering would it help to gain a breakthrough...

Thanks! My “analysis” was just a statistical estimation based on a median of wide variety of drugs approved and should be read only in that...

Here is my most humble effort to try to estimate how long it would take statistically to FDA approval and how the “fast lane” speeds it up: Of...

Could you clarify what you mean by "The articles I have been seeing are now saying 12 to 18 months... We will see if that happens, but that is...

If "improvement" means 2 dB then it is scientifically interesting, if it means 20 dB then the founders will become multi millionaires and get a...

While this is very positive news I get a feeling that Frequency Therapeutics is falling behind in schedule compared to REGAIN. They stated this a...

How does one know what is the ultimate cause of their hearing loss? Is it possible to find out if the cause is nerve related or loss of auditory...

In addition, improvements in hearing function, including audiometry and word scores, were observed in multiple FX-322 treated patients. “While the...

That clip can be found on YouTube and has a date August 23rd, 2017 so it's not new.

Isn't this clip from 2017? He sounds like the cure is just around the corner and makes wonder what have they really achieved since? Did they ever...

Nice clip, thanks for posting! Fast tracking plans confirmed which is good. Does someone know why they would need to inject multiple doses? Not...

Frequency Therapeutics must maximise profits and value from the technology as they have already raised some 90MUSD from external professional...

Good points. What I was trying to say is that the big news is that they got an external new investor who has seen all the data and after analysis...

I am not sure what kind of results people are expecting as it's only safety trials that are being completed. I doubt that much more is said than...

A financing round like this is always a validation for the technology/drug development in a way that the venture cap investors get full disclosure...

That is really great news! For sure those investors have had access to a lot more data than has been published and they decided to invest so the...

If we only knew what is considered by them "significant"... 10 dB or 40 dB... ;)

I am not too familiar with FDA processes but I read that a drug development company might get fast tracked if it is for a life threatening...

That is great news!!! Did they get already an EU approval for the completed safety trials? I guess that is the assumption if they are already...

It is really interesting that two completely unrelated entities are using small molecules trying to cure hearing loss and it's almost like a...

Current trials are to evaluate the safety of FX-322. I agree with you and hope there are no negative effects but that is what Frequency...

My understanding is that the reason for excluding people with a hearing loss of greater than 70 dB is that they want to measure both the positive...