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Glad to hear you're doing well. And yes, a little age drop from the local pharmacist is always nice!

This thread has gotten a bit confusing, so I just re-read it to try to understand where we are regarding the various ongoing and completed trials. The Matthew Carlson trial that the OP originally referenced was completed, and all 22 participants experienced positive results. It seems, however...

How are you doing, Michael? You've been away for a while, did the spike subside?

⬆️ This ⬆️

Notwithstanding the fact that the sham induced a placebo effect, you can't statistically validate the existing Treatment 1 loudness chart without actually having designed the entire trial as a single-arm trial. Ergo, Susan Shore's statement about how well the active treatment performed in...

After hundreds and hundreds of hours of research my unwavering opinion is that tinnitus is NOT caused by hearing damage; it's underlying cause is a neural gating deficit. Hearing damage (amongst other things) may result in lower upstream voltages consequently exposing the deficient gate...

There's no point in cutting and pasting TFI statistics because I'm only focusing on loudness reduction. Also, we don't need hunches, hope, or mystery. We need hard data. One breakthrough in Susan Shore's work lay in the fact that it would finally (as much as possible by today's standards in...

There's nothing hidden in that loudness chart. On the contrary, it's very clear for those willing to see it; the control didn't wash out either and exerted a negative effect on the treatment. Repeating their own spin won't change that fact.

This is definitely a discussion thread, but to be fair, you can only understand the delay if you acknowledge the problem within your own statement: That statement isn't conclusive because their own published data also indicates that the device isn't nearly as effective if preceded by a control...

Why don't you contact Peter Tass and let him know about Tinnitus Quest and the funding pipeline?

Yes, she was asked about this, and I believe the first time she referred to the "cross-over" effect was during the Tinnitus Hub Q&A. If you remember, at that time (a couple of years ago), she was asked specifically about the group that underwent the active treatment in weeks 13-18, and how...

Look forward to it (y) As it happens, E... I was frying with one of our pans a couple of weeks ago when the handle fell off. Ended up covered in onions, so I'm on the market for a decent new skillet. I picked some leaves this afternoon, having found this recipe, to try out, with steak and the...

Your wish is my command, D lol. Tried to grow some broccoli from seed this year. Hopefully, by Xmas, there'll be a bit more on the crown than this current state of affairs. You're never far away from my thoughts, @tpj, and likewise, it's always nice to hear from you.

I couldn't disagree more with this point. We ought to be way past contextualizing tinnitus science in this way. Providers of tinnitus treatment devices really should position themselves to complete the following most basic question with a binary answer: Does your device reduce the volume of...

Now that the dust has settled a little further over these past few days, I would like to say that the thing that still p*sses me off perhaps the most about the way this whole situation has played out is the chart below (which I'm finding increasingly difficult to locate online - but maybe that's...

All good here, D. I drop in every now and then, and am always pleased to read you're OK. Sending you a hug. @Elmer B Fuddled, glad to hear everything's clear, E. All the best to you and Mrs EBF.

I think it would have really helped if they had at least informed us prior that they haven't submitted to the FDA. When I discovered that fact, I asked a specific question about the last trial and whether or not the issues with the cross-over data would necessitate a third trial. Unfortunately...

I often feel like that just before going away. A couple of years ago, on holiday, reactive tinnitus underlined the entire trip. But in retrospect, I figured it was better to have endured the spike in the sun with a beer rather than at home, where it was going to do its thing spiking anyway...

It's small moments like this that enable us to claw our way out of the dark with reactive tinnitus, which is a very difficult condition to manage. For me, it's been a very slow road this time round; probably about five or so years. I think everybody's path is different. If the me from today...

There's definitely a psychology to dealing with tinnitus. Perhaps more so where worsenings after long periods of stability are concerned. My tinnitus was stable for circa 25 years until it went off like a crazy firework (including reactivity) after excessive headphone use about 7 years ago. So...

Stick to facts. Auricle are either moving forward with what they have (a product where the blinding process has not been tested), or they're going to have to re-run the trial. If they re-run the trial, they must either crossover (in line with their original promise to do proper science...

Interpreting a demand for the gold-standard science we have been promised as a lack of empathy is one of the most inverted comments I've read on here. Over the years, I've seen good, knowledgeable people driven away from these forums by that kind of tone. You should take your grievance up with...

Are you advocating for the release of a less-rigorously tested device? I think the trial design went wrong, definitely. As for the device, beyond timing changes, I don't really see how much road they have left in terms of developing it.

Evidently, those of us not in direct contact with Auricle are not privy to the latest information. I should also add that we don't know whether or not those of us who are in close contact with Auricle, but not directly associated with the company, are privy either. That side of the current...

I have not forgotten that last year, after their pivotal trial, which left many questions unanswered, Susan Shore and Jon Pearson completely shut down communication with Tinnitus Talk. That is why I find it really strange that, out of nowhere, a Q&A has now been announced. Susan Shore is almost...

Your doctor sounds like quite an open-minded person for suggesting grounding. I'm convinced there's something to it. I remember Mrs Elmer buying the other Toyota hybrid a couple of years ago. If you recall, Mrs UKB was also talking about changing her car around the same time. Well, enjoy your...

Great news, E. Time now to start cultivating that beard again ;)

ROCK 'N' FUCKIN' ROLL, E!!! I'm overjoyed for you. Nice timing too with Spring just around the corner. Much love to you and Mrs E.

Thanks, Ann! :beeranimation: EDIT: It got pinged back: I found reference to his personal website with contact details on LinkedIn but that timed out. Dunno...

I recently happened upon this paper authored by, Thomas Gisiger and Mounir Boukadoum, entitled: Mechanisms gating the flow of information in the cortex: what they might look like and what their uses may be Although there is no mention of tinnitus in the paper, the references to neural AND...

@Elmer B Fuddled, how you doing, E?

To be honest, I've largely skirted the "type of damage" debate because of the major problem I see with quantifying it. But I do think this is where Peter McNaughton's work can be interesting with, "temporary tinnitus after hearing damage", being a good example. We could have a case of...

This recent study on mice discusses links between neuropathic pain and hyperacusis. There's evidently quite a bit of research into the role myelination plays in neuropathic pain so it looks like the common denominators are there whether it's visual or auditory systems.

Thank you @Markku, @Hazel and the rest of the team for another fascinating podcast. It was a great listen. I find Prof. McNaughton's ideas intriguing, and would echo what he said insofar as it's always good when someone new comes along and shakes up the field. Tinnitus as a peripheral...

Nearly there, E. At least the end's in sight.

Try following them on LinkedIn. Or subscribe to the UMich Innovation Partnerships newsletter.

Did anybody press him on that comment? I can't remember... I've just done what I felt I had to and acquaint myself with these processes since Neuromod really started to look like a serious contender six or seven years ago (or however long it was). Regarding the age of this thread, you're quite...

Based on 50% of the pivotal trial data being unusable. We don't need to know about that. 50% of the data is unusable. Whatever they have been working towards cannot now be delivered. Read the first line of my post again. Then consider the facts and weigh these against the balance of...

Obviously speculation, but based upon the available facts and balance of probability, this is the situation as I personally see it: Regarding trial criteria, the UMich team set the bar of clinically significant effect as low as possible. This is detailed in one of the post-trial Q&As Susan...

When tinnitus becomes severe, it can be a very cruel and demanding condition that few people, even those who "have tinnitus," can understand. You're doing the best you can. You have to keep living your life.

I'm not sure I agree with the argument about self-reporting anti-depressant efficacy and the absence of an external reference point. It's scarce for patients to exist in a bubble; those around a patient taking anti-depressants will notice improvements in their mental state when the medication is...

He made that comment about 5 years ago here. I like that Dr. Nagler posted on Tinnitus Talk, but I do take issue with that particular comment. If the volume doesn't closely relate to the level of irritation or intrusion, then we're back on that slippery slope to CBT. I don't discount CBT...

Strange that it costs £110 to access that 2015 paper; I'm able to view the full document clicking your link. I'm not overly familiar with Rauschecker's most recent work, but the tinnitus paper of his that I generally draw on is this one. I've read comments that it's an overly complicated paper...

Within that statement lies the pretext for Jastreboff's infamous comment likening those of us who don't respond to his TRT protocols as "white flag wavers." To the best of my knowledge, Jastreboff's generation of tinnitus thesis has never actually escaped the textbooks and led to a final...

Merry Xmas everyone. Second half of 24's been a bit rough my side. Ears ain't getting better and that's where it's at. But somehow, I keep chiselling on through. If I can do it so can you. Big chin up for '25 to all my tinni pals :beeranimation:

Happy Days!

Big shoutout to @MindOverMatter one of the best dudes on here :beeranimation:

Glad to hear you're doing well, mate.

Re delivery; I believe there are already suitable systems out there. For example, I can't see why a modified TORS machine couldn't be used.

Re delivery; the needle trajectory absolutely does require the scraping or drilling of bone - "trephining" as the study refers to it. This occurs at the modiolous wall of the cochlear "for a median depth of 1.48mm". Access to that part of the anatomy would be gained via the round window with...

The above article answered the below question:

I still strongly believe that the root cause of tinnitus lies in a defective (for the most part, congenital) neural-noise gating mechanism. It's the only conclusion I've ever been able to reach, other than "bad-luck", which is not very scientific, that explains why some people get tinnitus...

Hey, D. I went through a period of reading Philip K. Dick novels. I think he's a superb author who almost invented a genre of his own but I did find myself having to really bump up my mood prior to starting each book because many of his stories would either severely p*ss me off or play too much...

Regarding those who struggle intensely; you're quite right when you say "that level of struggle is not the norm". Nevertheless, the problem with a comment like that is that a significant number of people new to Tinnitus Talk appear here struggling intensely - lack of sleep, hyper-focus, anxiety...

Thanks for the link. What Hamid has provided there makes for interesting reading. I think he's on point with a lot of what he says, but I disagree with him on point 7: Distinct from Hyperacusis: Although sound sensitivity may be present, the primary complaint is an increase in tinnitus...

I've spoken to a few people from the charity sector about the current situation at Tinnitus UK and they all opine the same thing, more or less: the charity has been mismanaged. I don't really know the details of their financial situation but Tinnitus UK lost me when they started with this...

Sound familiar?