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I can't think of a time frame till it will be available, but with all the recent developments (the partnership with Astellas, FDA Fast Track, new...
... I bet they'll just recycle some gamma-secretase inhibitor, nothing new. But if they eventually come up with a new idea, well, that'd be great.
Please note that also: the patients in the placebo group had no clinically meaningful improvement whatsoever; the tests were the same. If there...
Thank heavens for this. I sent a mail to the FDA last year in which I tried to argue in favor of such a classification, giving examples of how...
Dude, there were 4 patients with +100% (yeah, doubled) word recognition scores. That result simply cannot be due to blind chance. Most of the...
“The Japanese want to be the regenerative medicine center of the world” -- that sounds good. Long live the emperor! :rockingbanana: Also, a...
Yes, that's correct. At least, that's what should happen; initially they announced the results will be published on 31/01/2020, but changed that...
"A Phase 1b/2a study of PIPE-505 in SNHL is expected to begin in 4Q 2019, with topline results expected in late 2020." Nice, nice. So, by the end...
No problem, I'd be happy to try the dose used in the Phase 1/2 study, which is likely safe; I don't necessarily need good efficacy. Now I see......
Those of you who are Americans, couldn't you petition to the FDA and engage the Hearing Loss / Tinnitus associations to find a way to include...
It would work for sensorineural hearing loss, but there are other companies which are developing treatments for genetic hearing loss, if that's...
Woops, you're right. I've got some wrong info. It might be that he's actually McLean.
Awesome invention, looks like we're on the right track... that would mean they will be able to inject the drugs directly in the cochlea, like in...
That guy on Reddit (Leviathan or whatever his username was) is not Will McLean, it's a postdoc researcher who worked in Frequency's team.
No, it didn't fail. They just narrowed (or changed) the indications and are continuing the approval process. This is a quite recent video that the...
I think this would be the best option. It should be much cheaper to get the drugs approved in the EU than the US. If I'm not mistaken, you can...
Nope. Nope. Nope. I don't think it works this way. These growth factors probably don't reach the inner ear even if their concentration is...
Bro, I was just a bit scared for other people's health and pockets. Intratympanic injections with anything are not something to fool with. Maybe...
But it subsided after a while, right? Otherwise, the event should be reported...
Seemed to be permanent, from what that woman was saying. (yeah, I know, it's weird, because the drug is basically a formulation of esketamine, an...
I don't know anything about how effective Lenire is, but at least it's not risky as long as people don't hang themselves with the wires.
I think it worked in a subset of patients who had tinnitus from certain well-determined causes, like traumatic injuries or otitis media, so they...
Not really, I'm just cautious. And I try to evaluate therapies based on the available data. Shim's treatment is simply overpriced and unproven. I...
Well, actually you got a few injections with stem cells out of your butt, so idk what to say... (I tried to be polite, sorry.) But fine, go on...
My advice: don't waste your money on Shim's treatment. Wait until mid-end 2020 until we have results from studies that test drugs which are much...
Hey, I see you went to South Korea to that doctor, Minbo Shim. If he offers that PRP + stem cells treatment anyway, can't he offer...
I'd hug you now if I could. I'm in a similar situation, but I have pretty bad hearing loss (worse than you, in any case), and when there's (loud)...
Eek, so 4 injections, one per week. They will basically know how effective it is after one month, but the study ends September next year... damn,...
Yes, that's the downside of using only gamma secretase inhibitors: the number of supporting cells decreases, since those cells turn into hair...
Some guy from Hough Ear said mid (for the pill) to end (for the injection) 2020s, that is, 2025-2029, not mid 2020. +A question: If Hough Ear...
Nope, they will start Phase 2a this year and report the results in 2H2020 (at least that's what they anticipate). After this, if everything goes...
Guys, today I just thought that maybe we should do something to speed up the process and make this drug available faster somehow, and I have two...
I think it was an exclusion criteria if your tinnitus is more of a problem for you than the hearing loss, because their aim was to test for...
I think you're right somehow. Later edit: I used the data from that document, and if I'm not mistaken, yes, for the others, the average...
Well, until they get the drug approved... Meanwhile in Korea, Russia, China and a few other countries after Phase 2 results will be published:...
Any news about their presentation at the AAO meeting? And about FX-322's effect on mid-low frequencies: my guess is that it will reach/affect the...
By the way, in early 2020 we should have the results from Audion's REGAIN trial, and that one is in Phase 2 and has a similar mechanism of action...
LE: There would be a second possibility with the dose -- that the concentration was kept fixed (e.g., 0.1%) and volume was increased, with similar...
Yes, CGF-166 involved some surgery. There was this video with the first patient to receive the drug: [MEDIA] Afterwards, it seemed that the...
Hello everyone, I haven't had a Tinnitus Talk account beforehand, but I was following this thread, and I was a bit disturbed by all the...
