Search Results

Of course every scientist that fails should just quit.

According to his Linkedin, Will McLean (on whose research FX-322 was founded on) left Frequency Therapeutics in April 2022 and is now Chief...

Great news.

There is absolutely no reason to assume that the reason FX-322 failed is because the supposed regenerated hair cells had no nerve endings. Hair...

And if I might add: the hearing improvement must last long term. Some FX-322 patients lost their ‘gains’ after 1/2 years. Either the hair cell is...

Yes but lab findings don’t always translate into real life findings. It would be interesting to study temporal bones of patients who participated...

We actually don’t, not in humans. We only know the drug gets in the cochlea (they did two studies on this with patients who were about to be...

Fully agreed. I thought something was weird when they kept changing the goal posts after every trial. They already did that in 2019 when almost...

Yes, sudden hearing loss/deafness happens all the time, but I do agree that judging from what we know of the efficacy of FX-322, he seems to be...

Interesting. I wonder when the gentleman participated in the trial. If it was one of the earlier ones, his recovery could be attributed to the...

Mogrify and Astellas announce collaboration to conduct research on in vivo regenerative medicine approaches to address sensorineural hearing loss...

Otoprotective drugs are interesting to me as a hearing loss patient, because they can provide insights with regards to getting drugs into the...

Looks to me as if PIPE-505 did not achieve the results they had hoped for.

Just watched this Fireside chat by Frequency Therapeutics:...

It was a missed opportunity. The presenter asks the question at 25:45. Franck says ‘there’s a story there that kind of makes sense’ but he doesn’t...

You’re confusing criticizing a drug for its efficacy and instant gratification. Frequency Therapeutics themselves didn’t talk about word...

Possibly, but that would only make sense if supporting cells responsible for regrowth of IHC respond better to the drug somehow. Why would that be...

The press release made no claims about which region the drug and didn’t hit. Frequency Therapeutics Shares Clinical Data From Exploratory Study...

I just don’t understand these analogies. 1. The hearing range people need the most is in the 125-8000 Hz range. The speech range is in the...

“Just crank your hearing aids up to 110 dB bro.”

I thought it was telling one of the questions was why they don’t focus on FX-345...

There comes a point where we just have to admit the drug doesn’t work that well. When the Phase 1/2 trial hardly did anything for audiograms....

Reality.

On the one hand I’m glad they’ve come with something new, but on the other hand I can’t help but feel “here we go again”. It’s like we’re back in...

And yet here we are with a better understanding of how the inner ear works every day and multiple companies pursuing treatments. Maybe we’ll get...

At the same time, I can’t really blame people on here looking to get their hopes up instead of information. Treatment for inner ear hearing loss...

[MEDIA] Was this talk posted already? Couple of interesting points, particularly in the Q&A.

Back in the day people on here wanted to petition Trump to get this drug... And even now, Frequency’s monthly presentation still displays this...

Besides: better PTA on human speech frequencies = better speech recognition. It’s not like they don’t overlap.

By now I’m more interested in their R&D efforts than a drug that’s not designed to improve pure tone average, not even the extended range. Based...

The stock could tank even further and people here will tell you it’s all part of Lucchino’s Grand Plan. The truth is, of course, that they haven’t...

They can announce results AND follow patients for a longer period of time afterwards. One doesn’t exclude the other.

FFS, they said early 2021 when they announced the trial.

Why the thin-skinned reaction? It's not like it would be he first time a company overpromises and underlivers in the hearing field. "Local...

Can you point me to a source or is that your interpretation of ‘throughout’. I find it hard to believe it’s accurate, because it’s well documented...

What’s ‘throughout the inner ear’? I want a delivery method that can hit all frequencies of the audiogram (250-8000 Hz).

New trial (Phase 2) about to commence: A Trial of LY3056480 in Patients With SNLH (VESTA) What’s interesting is that they will use different...

How is a “previously disclosed” trial a secret? If I’m correct this is the study of which they already shared results concurrent with the failed...

I disagree. In Phase 1/2 the drug didn’t result in PTA improvements and WR scores improved marginally in about 35% of patients. Frequency...

Apparently they are contacting patients who didn’t get into previous trials that their next trial is about to start (source: people on Facebook).

They definitely put a spin on the headline. Getting kinda tired of this drug. No PTA improvements and no durable word scores. It’s ridiculous when...

Great news, and then this in the middle of the press release: “Of the five subjects that had a statistically significant response at day-90, the...

Adding to this: Anthony Ricci. He’s also from the Stanford Initiative to Cure Hearing Loss. He specializes in hearing on the cellular level. Him...

Interesting indeed. Apparently they can now take a look at human cochleas and hair cells in people undergoing brain tumor surgery (37:10).

Or cake with copium.

What still concerns me is the low response rate (around 35% in Phase 1/2) and that the presbycusis trial showed no statistical significant...

Their own press release said they saw no improvement in ultra high frequencies in Phase 2a...

I would take garlic pills, Himalaya kiwi’s or breast milk if it had any chance of improving my crappy hearing, that doesn’t make those things any...

I’ve read this thread marginally since FX-322 failed in Phase 2a, but where did this OHC/IHC thing come from? Has it actually been confirmed this...

The ultra high frequencies were already measured in Phase 2a. FX-322 didn’t do anything.

FX-322, a word score drug - even in the best case scenario - will not supplant hearing aids or cochlear implants in any way. You will always need...

10% improvement in WR scores only in 34% of patients. Nothing for the audiogram. It’s true current treatments for hearing loss don’t treat the...

The results of the Phase 1/2 trial are due early 2021, right? I’m very curious what the results will be.

I don’t think any type of technology can take away the fundamental drawbacks of intratympanic drug delivery. Those drawbacks have been well...

1. I wasn’t wearing a hearing aid at the time, so I didn’t notice any improvement. I only got a hearing aid when the WR score stabilized. The...

I’m not writing off the IHC regeneration theory entirely. We see strange things in patients with sudden hearing loss. The audiogram doesn’t...

If they really believe the grass analogy they should go back to multiple dosing with a new schedule at some point.

Wasn’t there also one responder who went down in WR in the follow up? How is that possible if IHC regeneration is the cause for these...

Am I the only who would really appreciate a podcast with the likes of Robert Jackler of Stanford or Zheng-Yi Chen of Harvard? Where are we with...

There was, in the first trial. There was a low dose and a high dose. Both were deemed safe, they stuck with the high dose since then....