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My pleasure. At HEI we try to be different than everyone else. I've tried to make it more personal by responding to emails, texts, forums, etc. I...

A huge thank you to everyone on here. I hope you all will still consider supporting HEI's research efforts. Right now, any new donor has their...

This is a report from our COO of HEI and our research team on the milestones this year with our proof-of-concept study: We were able to develop a...

Keep in mind this was an article written by a reporter. They don't always get the facts straight. Before we got connected to Dr. Kesari were...

To speed things up takes money. We are a non-profit that relies on government funding and private donations. The two-year proof-of-concept study...

Hi! I was in the room training the lady you spoke to. Let me clear up a few things that got misunderstood. NHPN-1010 is in a proof-of-concept...

The real term is expanded use. Read more here: https://www.fda.gov/news-events/public-health-focus/expanded-access Read more here:...

Yes, the cause of one condition can be the cause of a second condition. So, the mechanism of how the drug works can have multiple uses. Also, the...

Or blast-induced. There are probably several "causes" of tinnitus. We are going after the most prevalent one, at least what is thought to be the...

Incorrect, the article says patient, singular. Not plural. We also are unsure how accurate this article is and are inquiring. Sometimes we are the...

We have data on the pill's efficacy in pre-clinical trials for SNHL, ototoxicity, and tinnitus. We believe it might also be helpful with...

We don't know yet. The questions you are asking are generally found when dosing is determined, which is Phase II and III clinical trials. Our...

Expanded Use is typically done on a case-by-case basis. Reading the article, it talks about "a chronic tinnitus patient." NOT patients, plural....

Hi everyone, @Markku asked me to jump on real quick and give everyone an update on the news article from koreamed.com. I read through some of...

We didn't choose cochlear implant trauma. Which indication they (the biotech firm) choose is still in the air right now. The delays in clinical...

I don't think we have ever said 2024. If so, that would have been an error. We have consistently said mid-2020's. However some people thought that...

We have developed a novel way to objectively measure the presence of tinnitus. :) The phase II study with our pill, it is hoped, will be for the...

PoC studies are not done on humans. The hope is to get it into a phase 2 clinical trial.

I can't speak for Oblato, but I can share with you what they have shared with us. They intended on starting phase 2 trials this year. They would...

The process of a Phase II study and the actual phase 2 study are different, somewhat. The process begins with the study design, funding, securing...

Yes, it is the secondary objective in a phase 2a study. Not a full phase 2 study. It involved less than 100 subjects. A phase 2 study involves...

It's complicated. Frequency Therapeutics is doing good work. There are more than likely multiple causes of tinnitus. Their approach might be...

Hi Deb! The PoC study takes a total of 12 months.

Started September 1st. Yay!!!!! We will reach the rest of the goal before the end of the year hopefully!

I don't take it personally. I do however take it professionally when someone accuses me personally and the staff/researchers at Hough Ear...

PoC study will take a total of about 12 months. We should finish by next September. Then it will probably take some time, unknown, for Oblato to...

There is more data for hearing loss (cochlear implant trauma, NIHL, ototoxicity) than for tinnitus. It has nothing to do with confidence. The PoC...

@ajc - Thaun cleared up your previous statement in this thread already. I suggest you go back and read it to see how you misinterpreted it.

FDA approval often leads to a fast track with other country's equivalent to the FDA. Also, it fits in our mission. We can purchase the drugs and...

First off, if I said "we are starting phase 2 studies" that was a miscommunication. Hough Ear Institute doesn't run the trials. The biotech...

First off, Hough Ear Institute doesn't run the study. I'm not sure why people keep thinking that we do but we don't. The biotech company does....

That is the question the biotech firm has. Before spending millions on a phase 2 study they want some more data.

A PoC study is like a pilot study if you will. Before the biotech company spends millions of dollars for a phase 2 study for another indication,...

I wish Frequency Therapeutics the best. We are different in our approach and in what causes tinnitus. We both might be right! It's good to have...

The PoC study is to test an objective measurement of tinnitus as well as to see if it works for chronic tinnitus. All of our previous studies...

Thank you for doing the research and putting this together. I agree - research is frustrating because it takes so long. Whenever we are...

@tommyd87 Thank you for being more gracious about this than @ajc. I really have no idea what you are referring to. I challenged ajc to find...

When I first started commenting here - nearly everyone was very welcoming and appreciated that I actually engaged rather than share stock answers...

No, not yet. I need a personal introduction to someone, not just a name of someone famous with tinnitus. I'll check out the thread and twitter!

Yes!

Generally speaking, we need people to fund our research and those of others. For us, we have a $735K proof of concept study. It's funded to $605K....

No, it has not been submitted for publication. The pill has shown to regenerate meaningful nerve connections between the auditory nerve and the...

Thank you!

Much better said than me! Thank you.

Thank you. Agreed, rarely do people throw money away when their motive is to generate a profit.

Yeah, I think I might have had a little to do with it. Just a little :)

No worries. However, also with all due respect, I'll go with the science and the fact that we just received $300,000 from the state of OK and...

Correct!

Once the proof of concept study is done, then Phase II studies may be able to be started for the indication of tinnitus. One thing to keep in mind...

We are currently fundraising for a Phase I trial and we are in talks with several venture capital firms that have expressed an interest in...

Hi Alex, GREAT NEWS!!!!!!!!!!! We just got word today that our tinnitus proof of concept study received the grants funds necessary and they were...

I think we started talking with Oblato about 7 years ago give or take. The process takes a while and different cultures approach things...

I have 7 kids and #8 on the way. God has given me ample opportunities to grow in that virtue. Albeit, God had to take me there kicking and...

Good info to have. Thank you. If I ever come into contact with them, or someone who can introduce me I'll do my best to make it happen!

Funding. It took 5 years to get Oblato on board with taking it through the remaining clinical trials. We had other companies interested as well...

Top secret. I don't even know :)

In stroke patients it was not effective.

Your first question: Because we have done additional studies to show that it appears to be effective in chronic cases. Second question: Yes, it...

I mentioned it in a previous post. I'll try to find it and re-post it. If I can't I'll get back with the researchers. They know the answer like...

That's the rub and it is a little more complicated. I've explained it in previous posts but here is the short-short version: Obalto has told us...