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Fully agree on that. Expected more discussion after I dropped the transcription on here.

Just look at the mess damage creates: [ATTACH] Even the “healthy” hair cells are no longer properly aligned.

Isn’t the deal with Astellas for FX-322 alone?

I hear what you’re saying and both of you could be right, but at the moment I don’t want to draw any speculative conclusions beyond the actual...

I cannot tell with absolute certainty from that text if the epithelial scarring would affect hair cell regeneration, but the text confirms my...

Transcription: https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/page-216 Audience: Besides the word...

In regards to epithelial scarring: Cochlear pathology, sensory cell death and regeneration https://academic.oup.com/bmb/article/63/1/25/377504...

@FGG should send her personal letter as she pleases. Entirely her effort and her decision. Tinnitus Hub and the community can send an additional...

Hi @Jorge P. Simoes, It is really great that researchers are reaching out to the biggest tinnitus patient community. Thank you so much for doing...

As far as I know when a hair cell is removed from the epithelium, a supporting cell will move into that position to ensure structural integrity of...

Completely different. [ATTACH] People need to keep in mind that FX-322 only regenerates hair cells. So it can only resolve tinnitus for people...

I remember vaguely this has been discussed long ago, but I don’t know anything about this. What exactly leads to epithelial scarring? Why did...

I don’t think lack of supporting cells is going to be a problem for the majority of us. I wouldn’t even disregard Audion’s solution because they...

As far as I know it was never confirmed that his tinnitus and hyperacusis improved.

Do you have some good sources on this?

It seems odd to me that companies can buy the rights to a cellular pathway. So this means that other biochemical companies can not use that...

It’s because the whole concept was born out of looking at regeneration in animals and the gastrointestinal system in humans. They discovered...

Hi @brownbear, Nice to have an ENT with chronic tinnitus on Tinnitus Talk. It’s very nice to see you trying to help some people out by answering...

Very interesting publication on ototoxic damage to the inner ear which touches on intercellular connectivity, communication, collaboration,...

Tinnitus has been described as a thalamocortical dysrhythmia of the auditory pathway. Visual Snow Syndrome has been described as a...

“No matter which part of the cochlea is addressed by an investigational drug: Outer hair cells, inner hair cells, cochlear synapse etc (I would be...

Did Dr. De Ridder tell you that you have thalamocortical dysrhythmia?

Just want to add that it also included functional connectivity results (brain regions that communicate which each other). It’s the test which...

I expect them to be competitive enough to want the jackpot and the hiring information you posted proves that they are looking for a better...

I just went to Brai3n (Dr. De Ridder) and they did a Loretta qEEG test (with eyes closed and ear protection). Afterwards they showed me the...

Just confirming that my Loretta qEEG indeed also demonstrated hyperactivity in my auditory cortices. It’s a strong indicator of tinnitus....

FX-322 will improve your hearing. Both IHC and OHC will be regenerated at the cochlear base. We already have proof that it works. I suspect there...

About the study, I see, that is a very important viewpoint and not something I’ve heard before and clearly misunderstood that this was the...

It seems that many people think it will. If tinnitus is generated as a consequence of cochlear damage leading to maladaptive neuroplasticity, then...

I have read your thread to have a better understanding of your hearing loss symptoms (how exactly music is distorted for you). My knowledge is not...

My country has euthanasia laws. It’s not easy though to be approved for the procedure. Your family needs to support your request as well iirc....

@Hazel and @Markku, Tinnitus Talk provides better content than the American Tinnitus Association and British Tinnitus Association combined!...

It was a very difficult choice between 13 and 14. Research #13 is definitely a great choice as well.

I think the triggers are reasonably well known. Question is what the exact physical damage is (in the ear or even the brain) that creates...

That would actually be great news. Do you remember where they stated this?

Absolutely, but these would be the main individual components. Anyone surely has a combination of different scenarios. It is even possible that it...

It’s just speculation on my part. I cannot imagine this having no effect. I suspect it would be most noticeable when your hearing is challenged...

Research needs to focus on hard science. Tinnitus researchers need to do deep physiological, biological, otological and neurological research and...

I still need to have a deeper look at the current theories for tinnitus and hyperacusis and how exactly it relates to cochlear physiology and...

Small adjustment: Most common cochlear damage I suspect is: 1. OHC synapse reduction (synaptopathy) 2. IHC synapse reduction (synaptopathy) 3....

No sources for the impact of stria vascularis damage on hearing, pure speculation on my part based on my current understanding of cochlear...

I see dynamic dots all the time across my entire field of vision. The dynamic of the visual snow creates a heat wave like vision. It’s very...

I can only speculate on what the exact impact is of damage to the stria vascularis. I know it is an essential supporting function required to make...

I believe tinnitus can arise anywhere along the auditory pathway where there is abnormal neuronal activity that is interpreted by the brain as an...

I wish there was something I could do for you. I think I understand the pain well of losing so much. I’ve basically lost everything I worked for...

If the tinnitus is generated due to basic cochlear damage resulting in some form of maladaptive neuroplasticity, then it’s very plausible in my...

Sorry to hear this. Really would have been awesome to have an insider. I’m disappointed you tried so hard on the word recognition test. :p All...

You’re absolutely right and even then it is still an inadequate test. In my opinion all hearing tests are archaic and insufficient. By the time...

IHCs (about 3500) are the primary hair cells responsible for transmitting the auditory signal to the brain. They are mainly afferent and take up...

People with noised induced damage likely have less cochlear damage; primarily IHC, OHC and synapses. IHCs and OHCs may be damaged or may have...

Wouldn’t Frequency Therapeutics be capable of making a supporting cell “multiplicator” rather easily? If they can divide supporting cells into a...

I don’t think damage to the stria vascularis will affect the efficacy of FX-322 in any way, but damage to the stria vascularis will continue to...

I’ve done atlas reflex therapy and was told that my C1 and C2 were not well aligned. I’ve done two sessions where I was ‘cracked’ in several ways...

Why would the small molecules get deeper into the cochlea for IHCs than for OHCs? I don’t see why it would be any different for IHCs. They...

Awesome. Rooting for you. Do we agree on some secret language now or do we work that out later? Maybe post some rocking banana emoticons if your...

I’m puzzled by this. Why do audiograms (and OAE tests as well in fact) only test OHCs? If that’s true then ENTs are even more full of **** than...

ENTs knowledge is outdated. Extended audiograms must become standard. Ignore the ENT and go for it. Remember you may have lost lots of synapse...

It’s sad to say this, but this condition has made me no longer fear death. Suffering is all that is left and the only thing I can do is to stretch...

In my opinion the current state of imaging technology is the main reason why we can’t figure out tinnitus, hyperacusis, visual snow and so many...

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