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I have no idea why they are doing a Phase 2B trial because I don't know what they know. Maybe they've figured something out and are on the verge...
It impacts the whole study. After all, the liars weren't just put in the placebo cohort, they're also in the drug cohort. Therefore, if the drug...
Phase 2A drug and placebo groups saw improvements, and the same improvements, because they were both equally benefiting from the same flawed trial...
There's a great deal of conjecture in this thread about what that "improvement" actually was, and I'm not sure there's anything productive about...
Thread's like a car, bro. Got to start it up from time to time or the battery dies. :cool:
What you describe (what happened) is exactly a drug showing no signal at all. If there's no advantage for the group receiving the drug above and...
Because bias, and the word score boost attributed to bias, was equally distributed between participants who received the drug and participants who...
The Phase I results have been consistently overblown in this thread. Calling a handful of people "super responders" who appeared to do well in an...
No - the troubles with the outcomes appear on face value to stem from the fact that the drug didn't work. Everything else is conjecture.
I believe they said there was no difference between placebo improvements and drug improvements. Since no one knew if they got placebo or drug,...
Suggesting that someone has to "believe in it" in order to weigh in sounds more like religion than science. This thread is, in many ways, about...
That would be wonderful, agreed. But they have yet to credibly establish even that. (To respond in advance: 3 people who showed word score...
I think you should be neither optimistic or pessimistic, but rather realistic. Realistically, right now, there's no compelling evidence that...
Phase II results, with almost 100 participants, were devastating. FX-322 showed no signal at all, with no difference between drug and placebo....
Sure. Still, yours is a common position, widely expressed. And it's not lost on Frequency Therapeutics that a thread about the potential...
I disagree. The marketing team is searching for a name based on meaningful building blocks, which gives insight into their thinking, and the...
As a side note, Gacyclidine, the molecule in OTO-313, is similar to Ketamine.
Answer: I don't know. Do I have evidence? No, none of us do. Can I speculate? Sure. An enthusiastic audiologist artificially guided results in a...
Of course you're right that in those circumstances it is not possible to get up from a wheelchair regardless of determination, and I wasn't...
That's absolutely right. The obvious systemic agenda is to push the vaccines in order to eliminate sickness and death caused by COVID-19, and...
Performance boosts and placebos can do things that have historically not been possible. Concentrating can help someone get out of a wheelchair...
One explanation is that the drug worked. Another explanation is that other factors were responsible. I don't know. :dunno: However, given the...
We don't know that.
Great point, well said. The issue for Phase I, however, is that we're not sure if the 3 participants who scored well did so because their hearing...
You're mistaken. Ketamine has a short half-life, around 45 minutes, and has a history of broad, safe use as an anesthetic.
Fair enough. So how hard is it to double word scores in a small group? How many words were they given? What was the interaction like between...
Regarding deflated word scores, my point is that I just don't see how that impacts results as much as they indicated, given that artificial...
Thanks for clarifying. And if I may clarify, you are a "super responder" because your responses in this thread have been super! What I'm saying...
Agreed. I'm not sure it's helpful to vilify participants who joined the trial at real risk to themselves, or speculate that they're "liars." It's...
You've mentioned "super responders" quite a bit, but I'm not sure they exist. During Phase I, a few participants who received FX-322...
"Early onset" might distinguish from age-related (vs duration). :dunno:
I don't know that that's true. I know an increasing number of people who've received Moderna without any problems. At worst they feel crappy and...
We've created the narrative that FX-322 "cures tinnitus," and hopefully it does, but at this point, that's the theory. In practice, it doesn't...
I doubt it. There are currently no drugs that treat tinnitus. Assuming a drug emerges that does treat it, for example, FX-322, there is still...
I'm referring to dual purpose hearing aids that can provide relief from both amplification and white noise. Interestingly, tinnitus relief from...
Unless I'm misunderstanding, I didn't read @Poseidon65's comment as referring to earbuds. Rather, I read it as referring to hearing aids which are...
My understanding is that this is common and prescribed by audiologists using hearing aids to both amplify higher frequency sound (attempting to...
My admittedly uninformed speculation is that a single anything doesn't matter, whether it's a single hair cell, a single cancer cell, or a single...
Good that you're home. Take it easy and get better soon!
Scientists who study pandemics and warned about it for years.
Because we'll take the help from wherever we can get it. :dunno: If a drug provides a partial solution and a hearing aid helps on top of that,...
How does a drug like Otividex show positive results in Phase II and negative results in Phase III? Hope that doesn't happen with FX-322.
The stock has tinnitus! :eek:
No it's not. No they're not.
I appreciate your honesty. If you don’t experience something personally, it doesn’t exist. Got it.
Could be that one of the executive's kids told them they need to do more social media :dunno:
Is it fair to say that if you personally experienced severe COVID-19, but did not personally experience severe tinnitus, your opinion would be...
From what I can gather, there's a lot of "green flags" suggesting it's moving in the right direction. However, when I ask that very question to...
Phase I was 9 people with severe to profound hearing loss. That first toe in the water let them proceed, but hardly shows that FX-322 is well...
Wow... sorry to hear this. Hope you and your family recover soon!
What competition? None of these drugs yet exist in the market. I honestly don't think speculative potential competition years down the line...
It may be that people with good experiences aren't here in the first place. Also, given the financial and logistical challenges of HBOT, it's...
ASSUMING... FX-322 works, is safe, is approved, AND... ASSUMING... You invest in FREQ and make a bunch of money... ... you should use your...
I can't speak to the specifics, and none of us are experts in any of this because it's all so new, but my own opinion, for whatever it's worth, is...
For some, Nortriptyline and Amitriptyline do just that.
That's over 200%. Congrats! :beeranimation:
It's an exciting drug and an exciting stock once people discover it. It will likely go up and up, or crash and burn, based on subsequent reports.
ASAP: steroids, HBOT.
I'm not sure what trial you're talking about but I recall reading about a completed trial that poured Ketamine into peoples' ears through a tube...
There seems to be a fundamental misunderstanding in much of this thread. Post after post says “when FX-322 is approved…” and “since we know it’s...