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Best is to rest this thread at this page no. 666.
A clinical trial investigating the use of Chinese medicine formula (Bushen Huoxue Tongluo or "BHT") for the treatment of chronic subjective...
First they ask for donations, then they say pill, then they say a journalist got things wrong, then Oblato's website mentions nothing about...
Yes, and I wonder why tinnitus would be reduced by calming down the nerves if the input from the cochlea to the brain is still missing...
Is there any FDA Calendar for upcoming "Medical Devices"?
Can someone refresh my memory? OTO-313's (for tinnitus) compound is Gacyclidine. What is the mechanism of action for this drug? If this doesn't...
My guess is a Phase 3 FX-322 trial will run simultaneously with a FX-345 phase 2/pivotal trial in 2023... Since Frequency Therapeutics is on a...
Inner Hair Cells: Speech Outer Hair Cells: Audiogram
Erchonia® HLS™ for the Relief of Tinnitus Symptoms Trial is Active, scheduled to finish in January 2022. This study is to see if applying red...
As soon as they publish the failed results of the severe hearing loss trial in November I'm buying the dip, it will be great to start again at a...
Try this with the Aftershokz: [MEDIA]
Quick update: I have been using it for few hours now, not sure if it's placebo, but my tinnitus has gone down dramatically! Let's see how it goes :)
Or it could be like Elizabeth Holmes, founder of Theranos…
I just got mine today! I installed RAIN App (white noise) on my iPad and paired it with the Aftershokz and it pretty cool… I have it on very...
I hope this sentence satisfies you: If the root cause is not fixed at the site of damage, then we need a drug to shut the tinnitus up which is...
Yes. Tinnitus is in the brain. [ATTACH]
Man, in simple English, treating the root cause fixes tinnitus... If the root cause is not fixed, then we need a drug to shut it up...
You misread what I wrote: Damage can occur in either one of the below: Brain Nerves Auditory Inner ear Middle ear Blood flow Hormones...
They already know and examined ex vivo extensively... Tinnitus is activated as soon as any damage occurs in the brain/nerves/auditory/inner...
[ATTACH]
I recall seeing a possibility for the drug reaching 6,000 Hz.
Phase 1: currently being finalized Phase 2: we can expect it to start in December 2021, duration 1 year Phase 3: duration 1 year FDA: Apply for...
If you jump to the conclusion section, it will be scarier: “Even the median variation in sound pressure at the ear could contribute an error of 4...
“Manual pure tone audiometry is considered to be the gold standard for the assessment of hearing thresholds and has been in consistent use for a...
Many sources state the below: “Up to 10 dB is therefore an acceptable margin of error” Single Audiometry – A Basis For NIHL Claims Handling...
You can just say not sure... [MEDIA]
Sorry but the Phase 1/2 was done before fixing the bias glitch, so we can consider this study as bias also... For me, the severe trial will give...
Sorry to break it down for you but 10 dB Improvement is not an accurate measurement. 10 dB is not a tangible gap. 30 dB and above can be...
I feel not everyone is understanding what's happening, here is an example: Michael and Laura are desperate to get FX-322, so they both apply for...
Yes, those patients had improvement in word scores only. With current formulation and delivery method no audiogram improvement was ever recorded...
You cannot take or compare anything from Phase 2a. Phase 2a does not have a verified baseline from anyone, so please stop considering Phase 2a...
You got many things mixed up. I'm using my phone so I'll try to be as clear and brief as possible: Phase 1/2 is being claimed as successful, it...
Sorry but the Phase 2a was not an open label study... Everyone agrees that Phase 2a was a failure... The 3 super responders from Phase 1/2 is...
Severe trial is estimated to end in September, meaning readout will only be by November 2021. That's IF they have finished recruiting now......
Thank you @Diesel for your input, I appreciate the time you always take answering posts from members... I also really want this to work!
So since November 2, 2020 they haven't been able to find 30 candidates from any of these cities: Michigan, Nebraska, New York, South Carolina,...
ClinicalTrials.gov for severe hearing loss group just got updated. They are still recruiting... Also completion date has been pushed towards...
Mmm... some minor adjustments in your response: Short Interval Multi-dosing: No. Long Interval Multi-dosing: Maybe. Single dose for Audiograms:...
It's for this very reason that they should have done a placebo-controlled Phase 1 for moderate hearing loss. It was their chance to prove their...
CEO gets to buy shares at $0.61... :)
And to add insult they posted and hired a Chief Manufacturing Officer!
Why Frequency Therapeutics did NOT do a Phase 1 placebo-controlled study for moderate hearing loss cases? They did it as an open label. Why did...
I wonder what would be their excuse if severe hearing loss results fails... They will blame it on current delivery method :(
Let's first be able to scan cochleas and be able to analyse images of what's inside...
Frequency Therapeutics claims that FX-322 improves word recognition in mild to moderate cases (sensorineural hearing loss). Poll: How truthful do...
It should have been done to both ears (one drug and the other placebo) in order to cross check and verify if the candidate was lying… In the 111...
@Diesel “The FX-322-111 study was not placebo controlled, though the study analysis of untreated ears also showed zero percent (0%) exceeding...
What makes you feel sure that those who showed 10% improvement did not fake their WR also? Why do you only consider the placebo group as biased...
Recruiting: OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
No issue. OTO-413 is just starting recruiting. OTO-413 in Subjects With Speech-in-Noise Hearing Impairment
[ATTACH] Gentle Reminder - Goldman Sachs Conference is tomorrow. To avoid confusions on the timing, below are the actual timings depending on...
This guy explains clearly the cochlea. There are some interesting facts that I think everyone here should know, e.g., sound vibrations make...
No source. It was an edit over an audiogram referring as to which level of hearing loss FX-322 has the potential to treat...
Great info. So we can say these are the 2 possibilities going on preventing the full effect of the drug: [ATTACH]
It is already confirmed that FX-322 can pass through the Round Window. The question was, once the drug has already passed through the Round...
If anyone can advise please, if the cochlea is liquid, why is there a problem with the delivery?
So if the cochlea is liquid, why is there a problem with the delivery? The drug would diffuse everywhere!
Maybe FX-322 does not reach the Outer Hair Cells. That could be the reason we are getting a response on word scores only since Inner Hair Cells...
It means the environment and condition of the support cells in the ear are healthy enough for the drug to carry its intended purpose.
FX-322 works. To see it in Audiograms, you have to wait longer while they modify the delivery method.