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It is also noteworthy that tinnitus can develop from just reduced auditory input such as with earwax, sound deprivation etc. with no injury from...

Seems difficult then to tease out the relative contribution of NMDA activation and OHC loss to tinnitus generation by salicylate.

Another study with no surprises linking hearing loss and tinnitus/hyperacusis. Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute...

Heck, why not recruit all unilateral, high frequency tinnitus subjects to stack the deck.

Below is an estimation of the number of subjects in Phase 2a who will report tinnitus improvement: Total = 96 Non-placebo = 72 Estimated 70% have...

Unfortunately, Will McLean's highly informative YouTube "Toward a Cure for Hearing Impairment" has been removed. Wished I had at least recorded...

More evidence linking hearing loss, brain plasticity and tinnitus: Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy...

Below is Dr Lustig's audio snippet from presentation around 1:16:30. He made no mention of hearing loss leading to tinnitus nor of hearing...

Firstly, let's talk about the stock, one of the few times in life that free $$ was staring you in the face. Having researched FX-322 to death I...

I tend toward predicting a product launch late 2022 if endpoint results are met in the the three currently running trials with no adverse effects....

Animal models apparently could not withstand multidosing (presume anatomical differences) but human subjects can. Good news if multiple...

Attached below is an MP3 of today's webcast (Q&A only since the initial part was just a review of company's online presentation). I learned that...

Here is a screenshot I took from the WSJ article a while back: [ATTACH]

Quoting a Wall Street Journal article: “Fast track drugs often go to market after phase 2” I believe Frequency Therapeutics added the two...

With bilateral tinnitus cases comprising 39% and patients reporting poor localization at approximately 8%, TFI scores in the aggregate will not...

In order to arrive at a better understanding of what FX-322 can do for tinnitus, they really needed to shoot up both ears in Phase 2a. Results...

I am revisiting @Diesel's post regarding the audiogram differences between having tinnitus and not. This is, I believe, a pivotal finding. His...

Below is an excerpt from an article posted by @annV which suggests a link between improvement of SNHL and reducing/eliminating tinnitus. More...

Variations in susceptibility to tinnitus can certainly be attributed to sound processing variations among the population. An example would be...

Tinnitus improves with 83% of patients following tympanoplasty, a procedure which can restore function of the tympanic membrane and improve...

Our expectations regarding tinnitus results from phase 2a need to be tempered with the fact that subjects are being treated unilaterally....

Attached below is a link and snapshot to an article (Wall Street Journal) describing drug approval. There is a chance that the drug can go to...

As the gel solidifies it must be positioned against the cochlea, if the patient swallows during this time period or the IT injection is misplaced...

There are several limiting factors such as the drug's diffusion through the round window, whether the gel was positioned properly against the...

They got a doubling of the normal HC count in intact cochlea as revealed by Will McLean (18:29). I'm thinking a "damage signal" from adjacent HCs...

I thought the drug only activates the LGR5 cells which are usually dormant and are proximal to damaged and undamaged hair cells. If there is...

There may be many more "small molecules" in FX-322 than there are receiving sites in the cochlea; it's just they are not getting deep enough...

Here are 2 adjacent tones at 8000Hz with a 15 dB difference (one subject was tested with that difference from baseline). Be sure to turn system...

I am reposting this link and excerpt supporting the notion that regenerating OHCs will help with hyperacusis:...

Below is an 8000 Hz pure tone which changes upward 10 dB. It's significant. Be sure to turn your system volume down before playing.

How much a single ear treatment will improve bi-lateral tinnitus should be considered in the phase 2a study. There may not be stellar results...

It is interesting that in their updated August corporate presentation on their website they have decreased the frequency of action down to around...

Below is a study with a few attached excerpts detailing link between SNHL and tinnitus including correlation of intensity....

Getting into a clinical trial means maybe a few squirts of placebo, and if you happen to get the drug it will probably be in only one ear which...

Why regenerating functional hair cells looks so promising: https://www.sciencedirect.com/science/article/pii/S0929664615003848

With the prospect of a reformulation to reach lower frequencies and zero depletion of progenitor cells (numerous dosage potential) FX-322 may...

Studies have indicated that when hearing is restored there is a correlated reduction in tinnitus. For example: 82.6% of patients had improvement...

In phase 2a they are giving 4 injections which should demonstrate deeper diffusion into the cochlea resulting in lower frequency restoration. The...

Within this paper there is evidence that OHC regeneration may be helpful for hyperacusis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383716/

Not sure if anyone previously posted this study. Again, we see the positive effects of hearing restoration on tinnitus:...

It does seem plausible that repopulating with functioning IHC/OHCs will increase signal gain, thereby inhibiting tinnitus. We shall find out...

I know many of us are looking for reasons that FX-322 may not work but I think it's important to review a few things. Tinnitus is merely a...

I think it is important to recognize some possibilities with FX-322 and its probable impact on tinnitus. It is likely that the diffusion with...

A question was asked about whether FX-322 would reduce tinnitus and this was my reply: "If your hair cell damage and corresponding tinnitus is >...

In intact cochleae they got a doubling of IHC and OHCs which indicated a limiting or clamp down factor on the regeneration process. See Will...

If phase 2a gets top line results then hopefully that will trigger scaled up production which may allow for expanded access. It will be pricey...

I remember in their mouse studies they used an ototoxic substance to destroy hair cells and FX-322 worked very well on those cochleae.

From Frequency's paper below. Cell Rep. 2017 February 21; 18(8): 1917–1929. doi:10.1016/j.celrep.2017.01.066. Clonal Expansion of Lgr5-Positive...

I would not worry about Frequency Therapeutics not testing for tinnitus-related efficacy, with such a varied etiology I believe adding tinnitus...

Below is a link to a paper on the stochastic resonance model of tinnitus; claiming reduced auditory input as the main culprit. More promising...

Speech contains a high percentage of frequencies above 6000 Hz. Interestingly, most hearing aids top at this frequency which makes them limited...

Go to the link below and match your tinnitus tone by adjusting the frequency slider of the oscillator. If your sound is hissing or fuzzy it will...

If your hair cell damage and corresponding tinnitus is > 6000Hz, I would say very high. As they are doing multiple consecutive dosages in the...

Below is a link to a study whereby 82.6% of patients had improvement or elimination of tinnitus after tympanoplasty. Just another example of...

Luckily for us, FX-322 appears to regenerate hair cells regardless of the state of existing cells.

Unless I've misunderstood the process, FX-322 causes clonal expansion of Lgr5 cells (progenitors) and then converts them into IHC and OHCs with...

Will McLean, Ph.D. addresses this in an excerpt attached below from a presentation on YouTube: [MEDIA]

There are many articles supporting the notion that restoration of hearing in the offending frequencies will reverse the maladaptive plasticity...

In a previous Q and A the question was asked about benefits seen in secondary endpoints (of which one is tinnitus); the reply was "We saw trends...

Regarding FX-322 and its uniqueness among the vast majority of drugs which are typically injected into tissue, sometimes intravenously, or taken...