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Please let me know if you know. If you don't know, I would like to hear your opinion. There is an eye medicine in their concept. Can macular...

Don't those prospective drugs contain both a GSK-3 inhibitor and an HDAC inhibitor?

For example, if the contract contains the following text, isn't Astellas entitled as stated in the annual report? "Similarly, if any other...

I wanted to say that the current contract is about FX-322. And by your post, I understand the logic that the parties may be exempt from new...

Enzalutamide (Xtandi) currently sells $3.5 billion annually. It is a drug for prostate cancer. How many FX-*** patients will eventually be in the...

Astellas paid $3 billion when it acquired Audentes Therapeutics. In the future, Astellas will benefit in all countries except the United States...

I hope that FREQ will develop drugs that improve small molecules and gels such as FX-4 **, FX-5 **, and FX-6 **, and ultimately have a better...

What is stated in the annual report means that Astellas has exclusive marketing rights to FX-322 and similar drugs in countries other than the...

Is that your idea? Is it speculation? Did the contract text state that the improved version is also covered? Astellas does not have a patent....

There is a contract that they will be rewarded from Astellas for completion and sale of FX-322. Furthermore, if FX-322 is successful, I think...

I agree. And if the improved gel itself penetrates deeper, I think it will be more effective.

https://investors.frequencytx.com/static-files/bd82e199-8b2c-4c35-9929-3d7ed4cbcfc2 Please read page 15 of the report.

If you want to change the concentration, it will be a different drug and start over from Phase 1. You can avoid "redoing" by starting with a...

[ATTACH] What does "Formulation enabling evaluation of a range of dose levels" mean? Does that mean "FX-345 has different types of...

Was TFI a survey item in Phase 1b? Since there was an anecdote about improving tinnitus, wasn't it adopted as a survey item in Phase 2a?...

They state that Phase 2a could not confirm the effect of the drug for at least two reasons. One is the unusual effect of placebo and the other is...

What do you think is the reason why TFI was not published in Phase 2a? 1) It really didn't work. 2) Since there were many improvements in...

Slide P28 from March 2021: [ATTACH]

Unfortunately, I only know that it has improved by 10 dB or more. These four people seemed to be the same people with moderate hearing loss with...

Slide P33 in October 2019. It was an improvement of 10 dB or more. In a slide created after this, probably one year later, one of the four had...

I want Otonomy to show evidence. I can't believe their gel actually penetrates the entire cochlea just because they have a patent. Why is it just...

A mere claim without references is hard to believe. The possibility that FX-345 will reach 4 kHz and have an effect must be calculated based on...

I think this is because in Phase2a, there was an improvement in the placebo group that canceled out the significant improvement.

I heard they seemed to say in the webinar that there was no improvement in EHFPTA in Phase 2. Do you think this means "compared to a placebo"?...

They (Frequency Therapeutics) said they would reach up to 4 kHz until the Phase 1/2 results were revealed. 4 kHz was their immediate goal. It...

Is it registered as a trademark? They say it reaches the entire cochlea, but is there any objective evidence? Did you confirm the effect of the...

I have the same idea. And if that premise is possible, I want them to do it and succeed. I would like to see that there is no depletion of...

I would like to see another Phase 2b in 2022. A single (not continuous) injection at appropriate intervals (not weekly) for mild to moderate...

No drug works for all people and all symptoms. The important thing is to determine what works and what doesn't. And to maximize the effect and...

To be honest, I don't know and understand how significant a 3.1 dB or 6 dB improvement with BKB-SIN is for patients with severe hearing loss. I...

For that reason, I'm worried whether the video that FX-345 penetrates deeper is true. How far is the truth? That's why I posted about animal...

I think that the truth may not be known without animal experiments with mammals that are closer to humans than mice. But I don't know what kind...

I'm confused because I don't understand the basics clearly. Were there any articles in animal experiments that they improved hearing in...

[ATTACH] Initiating IND enabling studies.

This is a study of Kyushu University in Japan. It seems to be a technique for regenerating spiral ganglion neurons, not hair cells. It may be...

And the big thing is the success fee paid by Astellas. It is very important to show that FX-322 is an active drug (especially in HFPTA) and get...

I don't think Phase 3 is necessary for FX-322 because there are no competing drugs. What about if FX-322 is approved, is FX-345's competitor...

There is a graph on page 4 where VPA does not penetrate deeply....

I understand. So it means that it will not be confirmed until the reading of 113 is completed. The reason for the white letters. 111 contained...

The size of these two circles is too small because the number of patients with severe hearing loss and the number of patients with presbycusis are...

Where can I find the materials for this presentation?

"Clinical data review from four completed FX-322 clinical studies, including 169 subjects with a range of hearing loss severities and SNHL...

Did they measure PTA in FX-322-111? Or are they not announcing it because there are no significant improvements?

The severe hearing loss trial can fail, but in that case it will be Phase 2 (re-challenge) without severe hearing loss. The final conclusion is...

There is no proof that hearing was regenerated. However, there are no reports that it has not been possible. The possibilities aren't gone. If...

I look forward to a detailed announcement of Phase 2a later this year. So far, only the number of occurrences of WR group level improvement of 10%...

Is it a guess? If there is evidence, isn't it a breach of stock manipulation if they were lying? Have the legal proceedings actually been filed?

Then, there may be a possibility of improving PTA. After all, I would like to see detailed data at the individual level. Then, it is possible...

What does this part on page 2 mean? Is it just about WR? Does that mean that WR, WIN, and PTA (including EHF) did not show any effect over...

Isn't an "adverse event" a side effect caused by an injection? However, there is no tinnitus in the placebo group. [ATTACH]

Excuse me. Does "the lack of audiogram improvements" mean "there is no mention of audiograms"? Excuse me, but is there a statement somewhere on...

Does that mean FX-322 isn't dead yet? You still have hope, right? If so, I will be happy and cry.

It means whether they are injecting placebo into the candidate's untreated ears. By the way, in placebo-controlled clinical trials, I think that...

I hope that the detailed disclosure of Phase 2a in the second half of this year will provide information showing that the drug is working. This...

According to @Diesel's memo, wasn't the announcement postponed to the second half of this year? Will it be announced in August / September?

Speculation is just speculation. Moreover, our knowledge is inferred from limited information, no matter how hard we try. It may be completely...

Inner hair cell priority is speculation in this thread. Frequency Therapeutics have not made such a statement.

The statement could be the number of patients who have improved, both in WR and audiogram. I think it may not be the magnitude of the improvement...

So far, no official announcement has been made. Also, I think they should have only obtained group-based significance information in the interim...

Is there a possibility of early July for Phase 2A details?