Separate names with a comma.
:rockingbanana: More awareness for hyperacusis is always good.
Stay strong everybody, this is horrible news.
So much for being a "patient" organisation. How sad.
Unexpected loud sounds can trigger inflammation in the middle ear, even if it doesn't lead to cochlear damage. Source: An Integrative Model...
2 nice things I found during the past week: - Hyperacusis Central made a short video called "Sound of Tinnitus" to show others what tinnitus...
That is so relatable :( Fortunately, a method to detect tinnitus has been developed. The Bionics Institute is working on a different one. Nothing...
4 actually. Fear and annoyance hyperacusis too.
Because people hope/wish that regenerative therapies will cure them while Susan Shore's device will "only" be a treatment.
[ATTACH] Hyperacusis: Results of a Novel Treatment Approach Please ask them what their scientific source is when claiming that protection...
I'm shaking my head here man. You're the one telling Travis Henry what to do, yet apparently I'm the one with a hidden agenda and should think...
Whoah that is some dangerous advice. How do you know protection leads to worse hyperacusis? Can you show us evidence? Many people, including...
Like someone else said, it's probably the hype starting again. Although for once I hope it's insider trading :LOL:
Welcome to the world of clinical trials!
Damn they couldn't even find a buyer for their remaining IPs.
This video talks more about her research and how exactly they can detect tinnitus in our brain. [MEDIA]
FX-322 and FX-345 are different drugs, I'm not sure why you think they would wait for results of the former.
How exactly do the medications you mention help with what that paper describes? I've wondered myself how muscle relaxants could help with TTTS...
Frequency Therapeutics Announces First Patient Dosed in Phase 1b Study of FX-345, the Company’s Second Therapeutic Candidate for Sensorineural...
Don't share anything.
Exactly! This is a start. Susan Shore is a scientist, she will run experiments on how to improve the device. Other researchers and pharma will...
All of what you've said is very true. In their defense though, Otonomy did release Otiprio for swimmer's ear. They later sold it.
Let's hope so!
Invest that in fundamental research instead, like Hyperacusis Research.
It didn't. The higher dosage trials failed (and so did their tinnitus drug, OTO-313). Otonomy Reports Positive Top-Line Results from Phase 2a...
Then nothing happens with this drug. OTO-413 is there for that.
It is common knowledge that CEOs take business decisions based on mails by random people.
Otonomoy's OTO-6XX is aimed at hair cell "repair" instead of regeneration. Unfortunately the company is in a really bad shape so I don't know if...
If you regenerate the hair cell, the synapse restores on its own. [MEDIA] Around the 29:00 mark.
Reading your post reminded me of Bryan Pollard. He also had an engineering approach when founding Hyperacusis Research. May he rest in peace....
I'm gonna nitpick here lol, but AlphaFold's breakthrough is in protein structure predition, not protein folding.
Which one of those have hyperacusis?
She finished second.
Good point :)
If you would actually read Otonomy's press releases, you would have known this is not the case: Otonomy intends to initiate a dose-ranging Phase...
They have already stated multiple times that they will do a full Phase 2 first.
Btw, the main author of this research is a Belgian PhD student and finalist in the Belgian PhD Cup. I hope she wins, it would bring quite some...
Belgian researchers are also working on this.
Even if their hearing drug flops, their MS drug might save them; who knows.
Thank you for correcting me. The results will indeed be published in the second half of next year, not the first.
I'm not sure if this has been posted before, but Frequency Therapeutics uploaded a new corporate presentation:...
Why don't you look on their website?
Their Phase one trial was finished back in 2015. The current inflation and interest rate rises didn't cause companies from picking up the drug...
He posted a new update on his blog. He saw further improvements. He's at 9 treatments now. https://www.tomparijs.nl/2022/08/23/behandeling-7-8-en-9/
That's what I think too :( Something is off when you claim to have such a great drug, yet struggle to find investors. Even when they did partner...
Please properly inform yourself before saying things like this and giving people hope that this drug has a possibility to release in 2025. There...
We need a control group to answer that question.
The study ended about 2 months ago, I wonder when we'll be getting results.
That doesn't really matter, you need a control group to see if the improvement is linked to the placebo effect in any way. Just look at the...
That study doesn't even have a control group.
Sigh.
Some of us hypy sufferers have taken the time to (re)write Wikipedia articles in various languages, to make them more up to date with the latest...
To add: the results of these higher dosage studies will be out this quarter.
As long as the results are good!
We were all wrong, fortunately! Results are looking pretty good, actually: 87% of patients who experienced ototoxicity in their placebo-treated...
I'm sorry to hear that. I hope you'll get better soon. Many here will disagree, but you might want to consider wearing earplugs or earmuffs when...
They sure are taking their time to report the interim results on their otoprotective drug, Q2 is almost over.
Afaik we only have a quote of their CEO:...
Xenon Pharmaceuticals Announces Positive Outcome of End-of-Phase 2 Meeting with the FDA | Xenon Pharmaceuticals Inc. (xenon-pharma.com)
Check the full schedule.
Perhaps, or perhaps Frequency Therapeutics has better tech. Time will tell.