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I took 30 mg pills orally, but it didn't do a lot from what I remember. I tried it topically because of a few articles I read around that time,...

Good luck with it. Would you mind asking them the burning question about the reversibility of the surgery (in the case that it did not work, and a...

As long I could have music and noise back in my life again and that noise was not causing me pain while listening to it (or after / delayed) then...

I have got some but not tried it yet because I'm not in that much pain right now, bored shitless in silence though because every time I test my...

That's interesting @grate_biff, I always thought you had face pain with your noxacusis, and the way you describe your tinnitus is the way mine...

I don't know but my symptoms range from ear fatigue/reactive tinnitus through to setback pain which is on a different level completely. Although...

From what Ive read I think a good theory is cochlear inflammation that stimulates the trigeminal nerve endings that are actually in the cochlea....

I'm a bit hazy on this, haven't done much on it for a while but the conclusion I came to is that FX-322 could work as long as it either, a) fixed...

I've been reading some threads from around 2015 / 16 when quite a lot of people were trial treating with Trobalt and something else called...

@Born To Slay, @Marin, thanks, that's very helpful. I'm hopeful for the Xen drugs as I understand they are reformulations of Trobalt. When I...

Hi @Marin, I got some Trileptal recently (28 days 600 mg per day). I haven't tried it yet but I can't find anything to suggest it's something that...

Ah, yeh mine might have been a bit different. They were coming through slightly angled and were partially out but still had not quite finished but...

@weab00, I had this done when I was your age for the same reason, all 4 wisdom teeth (no noxacusis at the time though). After the anesthetic...

Yes I think the initial instant pain is cochlear related as well because it happens in real time as noise hits and is frequency specific and then...

I struggled to figure out the best way of writing this for a while, but I imagine a (not that unrealistic) scenario where all regenerative drugs...

I'm losing hope

Good find, blows my latest theory to shit, nice to know this kind of testing is being done though. I think I must have massive IHC damage and some...

I'm focusing lately on how OAE tests could be useful to measure improvements in the inner ear that aren't detectable on an audiogram. The theory...

I hate the idea of the blocking the round window without any good indication that it can be successfully reversed if need be (I've been trying to...

You're on the same page as me and that's why I wonder about the OAE test that I brought up yesterday. Bear with me - I'm going to try and do with...

Regarding the +-10 dB margin for error, would it not depend on the average across both cohorts though? On a case by basis the margin of error of...

Yeah, and what's funny about that is that they are the same people who give the OAE tests which can indicate damage in a hyperacusis complainant...

As long as absolutely none of the placebo group improves and that the FX-322 group does improve. I reckon if just one of the placebo patients also...

I completely agree with you, but I dream.

This is why I'd love to see a spin off trial on people who are so debilitated they can't even leave the house or function around anything that...

@Zugzug, thanks, I didn't realize that study was non placebo controlled. It looks like FX-322-112 is though but I can't find whether or not...

Yes, and not just lied dramatically but also happened to ALL get into the non-placebo group, right? I'm really hoping that there are zero...

Thanks @Diesel, great observation. They would have had so much time to prepare for that presentation if they had known. Plus the continued extra...

@Diesel pls can you check my last post (forgot to tag you). Need your analysis on first point. Tx

Re the additional Phase 1b trials that were announced quite out of the blue if remember correctly - I wonder if these studies were made up quickly...

I just heard it properly. Phase 2a and 1b shows nothing in EHF. It's all based on speech recognition and WR only,

I was wondering where this doubt comes from. I thought they were talking about groups as in just Phase 2a subgroups? FX-322 vs placebo etc....

I was having trouble with a lot of it myself. I actually missed that bit in the presentation but it's been mentioned above in the thread a couple...

The Phase 2a study seems null and void because of bias, fair enough, but what's the deal with the Phase 1b study because on the one hand it looks...

@Marin, I've come to the conclusion that stimulating the area is dangerous when it is highly sensitized (I think in terms of trigeminal nerve area...

Exactly @Aaron91. If I'm right in thinking that ribbons, along with extra, enlarged ribbons die along with an OHC when an OHC dies then it would...

To @__nico__, @roy1159, and @AliasM (& you all), the last few pages have been tough to read as some seem so close to the edge. Keep going. A...

This is maybe a golden find @Aaron91. It helps me join 2 maybe major dots together in my own theory. I've been working on something as you know...

I see what you mean about the protection. I guess in the early days it's hard to gauge but after a while I learned by trial error what I could get...

You're very welcome, and thanks for all your help in the past. Thinking about it I can see these all being variable factors which is why the...

I spent a long time trying to work this out as well because it quickly dawned on me how crap and effectively useless LDL tests are as there's such...

Good question @Zugzug, but no it wasn't like that because I was bracing myself before it began anyway (with the right ear) which was OK, more than...

I had an Ultra High Frequency audiogram done and the results were more or less what I expected and also threw up a caveat I was hoping for. I’d...

I've read a lot of your posts lately and really feel for you. A concern I've always had is the thought of having even more problems on my plate in...

I have had so many thoughts of suicide over the last 4 years and not just suicide but fear that I'm dying anyway, my health seems to be collapsing...

Thanks for clearing that up, and I'm really sorry to read about your recent symptoms.

I hope Ebselen does well. It was bad news about Otividex Phase 3 failing again and I sort of have this drug in the same category although they are...

Bad news about Otividex trial failing again, I really hoped it would pass because this makes me nervous for SPI-1005 as I kind of understand they...

I just wanted to bump this question for anyone trying to find out about this surgery. I still can't get this answered to any degree that gives me...

I've started reading a bit more into this, one thing really confuses me though. The cochlear implant seems to get inserted into the Scala Tympani...

Good thread and well timed, my thinking is steering the same way recently. As we know the extra OHC ribbons research means that an OHC has to be...

Just to add, I believe this does naturally happen anyway as noise tolerance does tend to recover after each setback, even if it takes months it...

I still hope that this threshold would recover over time once the underlying lying cochlear problems were fixed. If it didn't though then yeh...

Every theory seems to lead back to needing to take care of the sensitized type IIs above all else for noxacusis. The only other hope I've got is...

Yeh it seems pretty obvious now doesn't it that there has to be an OHC there for the extra ribbons synapses to even happen (for type IIs). With...

I've been thinking about this from the OHC perspective where the ribbon synapses increase in number upon noise trauma, and how FX-322 could be...

I had a setback last night after doing quite well for a few weeks, just hope it's not a bad one. I'd do anything to try this stuff right now.

Yeh, it makes me wonder that although the insertion of a cochlear implant is obviously very damaging to what's left of natural 'good' hearing...