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This is already occurring at present. Pretty much there are two main aspects being assessed right now to improve this. The first is that there's...
A lot of individuals do not have hearing loss below/at 2 kHz anyway who would be in the target group for Frequency Therapeutics. Thus this is why...
They would, however they would reduce a lot of the lead time since a lot of the lead in work such as the preclinical studies etc is already...
There has already been a lot of development around nanoparticles and therefore it would seem a plausible and logical option.
Correct, which is why an implant is seen by many as being vastly superior to pretty much all hearing aids. As a result the only way improvement...
There have been claims from some saying they'd eliminated hyperacusis also with the implant.
I think it will get released right after it is given approval. At this stage it seems that the biggest barrier's been getting it past that.
The problems with audiograms are actually absolutely understated too. There have been recent examples of the audiogram being the sole measure that...
There was commentary put out from some about how hearing loss leads to dementia through the recent results of a fairly sizeable study and some...
Even if it is developed as a speech understanding drug, this is still helping with hearing loss even if there is no improvement on the audiogram....
Why would that stop speculation about how they can get the medicine the whole way through the cochlea? Can't improve one's understanding of speech...
If you mean will the exclusion criteria likely exclude groups of people who have got tinnitus from participating, then the answer is likely to be...
So if no one benefitted from the medicine then, explain why those who received it subsequently demonstrated improvement? I think that @Chad...
I get this study now, however it seems on face value that it is only referring to a specific subset of tinnitus and not all kinds of tinnitus....
I don't get how blood flow can be related to tinnitus at all.
Not necessarily. There are people who have got a moderate hearing loss who perform very poorly on the speech recognition components of the tests,...
Could be that the data on the website has not been updated.
Is that why Frequency Therapeutics had successful outcomes/measures from both in vivo and their single dose trials then? That doesn't flat out...
If something worked only to suppress the symptoms then I think that this would be a real win and most people would be satisfied with that...
This debate has been had before but basically there is not much debate as to where it comes from (brain) but the debate is around whether it is...
This is not the first time that there has been a treatment trialled a significantly long time ago which has not progressed further for a number of...
Hubert Lim was working on his device at the University of Minnesota and then he abandoned it to go and work with Neuromod (Lenire).
Cochlear Implants.
I don't think that this necessarily means that they have nothing to commercialise at this time. Rather it sounds like they need to work out or be...
Taking that type of approach leads to problems getting things passed/approved by the FDA. From what we have seen thus far, the FDA requires very...
This is quite questionable though as a lot of people are helped by medications like penicillin etc and the success rate would be also...
I think that there are three things you need to consider with the outcomes of this OTO-313 trial. 1. 43% gained benefit, which is positive. The...
I think that this is somewhat promising. I thought that there could be a longer delay before it is in the trial phase. It is just promising that...
I think that the benefit with the Otonomy medicines might end up being their delivery method. Not guaranteed but if their last dose got done in...
Unfortunately I do not think that they will respond to emails about asking for information relating to clinical trials, as they usually have to...
Interestingly multiple of these papers don't actually rule out the use of intratympanic injections totally and also point to issues such as the...
Yes I think that the administration method might end up being the bigger culprit when it comes to the effectiveness of the medicine currently....
I believe it might have hence how I stated that there tends to be an analysis of safety outcomes if it is required.
Phase 1 is where safety is predominately tested. Thus this would mean that the treatment would have likely either got canned or been made to fix...
I think that the biggest issue that Frequency Therapeutics has got right now is that it needs to reevaluate both the dosing methodology and also...
The question is though whether the placebo would have mucked up the dosing of the medicine in the same way. At present there is no information to...
I don't think that there was any evidence at the time to demonstrate that the multi dosing would result in adverse outcomes which was why...
The candidacy issue is indeed Frequency Therapeutics' issue. The dosage schedule not so much. Majorly difficult to know and/or predict how a...
Why do you think Frequency Therapeutics botched the clinical?
Yes if these devices do do the things that the developers/researchers believe that they can do then I think that there can be a real benefit from...
Not to mention that there tends to be little merit to their claims and little evidence it will succeed either. Essentially it just looks like they...
Go and have a look on the Cochlear America site or obviously other sites like Australia etc. I'd upload it, however it is too difficult to do on...
Not necessarily. No longer is there a requirement of profound hearing loss before you meet the criteria for a CI.
Pivotal trial = Final trial before FDA Approval is given to a medicine. Medicines can be released for compassionate/expanded use after Phase II,...
I think that there wouldn't have been much discussion on OTO-825 or OTO-6XX because they are also actually not out of the pre-clinical work phase...
This isn't necessarily true. A lot of people have hearing loss from the audiogram perspective and no tinnitus.
I think that these guys are actually on a promising pathway with what they are doing when it comes to the research and techniques side of things.
This organisation is right here in Melbourne.
I have seen indications which suggest the opposite when it comes to tinnitus that it is often present in older people. The Hough Ear Institute...
Looking at the comments from Otonomy, it seems like they aren't able to comment and/or determine whether the medicine has any impact on tinnitus...
Thanks. I had not seen that tinnitus was commented on in the original trial results. Can you show me where in the transcript it says this as I...
- To be rational when it comes to the Hough Ear Institute pill, the initial trial was done with people who indicated that they did not have...
People in academia wonder why we don't take a lot of their work seriously - answer they come up with silly stuff like this which has no benefit or...
The thing that we are aware of is that there have been delivery issues with the current method. Most certainly this is why other firms have not...
It is a problem regarding tinnitus and using hearing aids when related to no hearing loss on an audiogram. As a rule I cannot see how tinnitus...
The Oticon More technology is pretty positive when it comes to dealing with tinnitus. It works in a manner which is completely different to other...
It is inevitably possible that multi dosing could work. What would have to be identified first though would be how long it takes for a single dose...
The thing that has not been covered in his analysis relating to hearing aids and tinnitus relates to three key things I believe. 1. I agree with...
I don't know what you mean by larger? Looking at it, it won't be larger than the first single dosing trial in terms of numbers.
Totally true. The first change to this trial will be the fact that participants will get screened appropriately to start with and actually...