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Because it is based off another drug that was apparently quite effective for tinnitus but unfortunately had too many side effects and had to be...

Didn't Trobalt pass a safety test, only to reveal major side affects later on?

Has anyone heard how this thing went?

Yeah you're absolutely right. It's just that if you had the type of blood cancer the new drug didn't help, it would be personally disappointing....

I agree. There was a lot of emotion riding on good results. All I'm saying is that people need to recognize when emotion is in the driver's seat.

Yeah, possibly! Again, remember when he showed up and so many people jumped down his throat and aggressively mocked him?

Wow, I feel dumb. You are right. I read it as "previously undisclosed". This got less exciting. Now it sounds like they're just trying to salvage...

Without investing too much emotion, this seems like a good sign. Basically a secret trial that if it had bad results, would be swept under rug. I...

"The greater good" is exactly why they did it. That is why they are known as the "greatest generation". They knew the risks but also knew what had...

Imagine if the soldiers on D-Day were like "I'm not storming the beach on the first day! I'm not one of those suckers who are possibly gonna get...

I can't be bothered to bring up the exact numbers and percentages but I remember that if you really looked at the numbers, there was only a small...

Agreed. At least prior to the Phase 2a results, all the available evidence looked very favorable. Coming out against it was more based in...

I am on the side that thinks restoring input to the brain can lessen/stop tinnitus, at least sometimes. However, I do appreciate your scrutiny as...

Ahh ok, cool. Thank you very much for the explanation!

Sorry, so what's the take away from this? Thanks!

I've honestly never been super optimistic about the multi dosing hitting lower frequencies, it just never made sense to me. Full disclosure, I do...

After seeing this post, I bought a pair and I really like them. I can wear them all day and still talk to people with no issues. They take the...

Thanks for the breakdown. I subscribe to the idea that the drug, in its current delivery form, does repair hearing to a limited but still...

I think this is positive. Everything pointed at single dosing giving limited but solid results and they kind of jumped the gun with their Phase 2....

Same. I also noticed that the popular understanding of IHC and OHC changed. Until the Phase 2 results were released, everyone was saying that the...

Completely agree. It's the idea of it getting worse that I worry about. If it was frozen or whatever so it never gets any worse, that would be...

So wait, is this kind of like Lenire or whatever in that it tries to reset a part of your brain, except by using some sort of pink noise input...

I think the progress was that they learned some new things that gives them a good foundation to go further.

I agree. They already tried to fly too close to the sun with their gamble on multi-dosing for their Phase 2 and it cost them. Stick to what seems...

I definitely understand your disdain for information silos, echo chamber etc and I can definitely see it happening in this thread from time to...

Exactly. It should still benefit mild hearing loss and that is displayed in the detailed Phase 1/2 results. It's just that the ceiling doesn't...

Yeah the thing about mRNA, from my understanding, is that it's relatively simple to program your desired result. This means that the process of...

I probably don't know what I'm talking about, but it seems like they are suggesting that a therapy for tinnitus can be created by introducing...

Honestly, any improvement is great for the not-severely compromised person. It may give lots of people a second chance who maybe went to a few too...

So you're saying it's kind of like a "slow and steady wins the race" kind of thing? Like "get good, then go fast?". Couldn't they just have done...

How does this speed up clinical study process? Legit question because to my uneducated brain, it seems like a redo of a previously favorable Phase...

Yeah but that's basically just saying that the new hair cells regrow completely. A hair cell without a synapse is like having a cell phone without...

Yeah exactly. It seems like they are quietly walking back on the benefits of FX-322. If the Phase 1/2 results are truly indicative of what it does...

That's all very cool and promising stuff! Seems like every week, we are receiving more and more news that how the science world is starting to...

I think it depends on what your issues are. For me, I have no issues until the end of the audiogram and even then, it's not a crazy dip, just...

Alright, cool. Glad we are on the same page haha.

Sure, here are some screenshots from the previous page. [ATTACH] [ATTACH] Maybe this is also a case of everyone misunderstanding everyone....

People were saying that the audiogram of the Phase 1b-111 also had 10 dB improvement at 8,000 Hz. All I want is for people to know that is false,...

OK. This isn't providing any details that I'm trying to get at. Maybe those details don't exist yet? Fine. I'm just saying be cautious if there...

I'm talking about the Phase 1b study that everyone has been quoting as "successful" because it replicated the same results as Phase 1/2, which...

So can anyone provide the audiogram data from Phase 1b? Or do we now admit that people were just repeating completely false information?

Yeah. I mean, maybe since it looked at "mild to severe hearing loss", they actually did replicate the same results as Phase 1/2, when broken down...

I did read the slide. Unless I'm totally off, it seems to refer to Phase 1/2. Where does this 2 month old information that audiograms improved...

That's Phase 1/2. I'm talking about Phase 1b. I know Phase 1/2 was successful and in my opinion, it was great. I'm concerned about this second...

Where do you see them mentioning any kind of audiogram improvement? They only mention some word score improvements. I'm all for the theory that...

So I 100% think the Phase 1/2 results are very promising because when you look at the data, the people who had room to improve a lot, all improved...

Sorry, I must have missed something. What are the two successful single dose trials? I only know of the Phase 1 safety trial from a couple of...

Your synapses are likely damaged. You have also lost hair cells. Both drugs that regenerate either synapses or hair cells will give you some...

I think it is safe to assume that most people with tinnitus have a few issues wrong and fixing one issue can provide at least partial relief. So...

Yeah, without going down the rabbit hole of wishful thinking theories, that's what it sounds like. However, the fact that now this massive...

Success is NOT a straight line. Several tests and experiments showed that one dose works to a certain degree. One test showed that multiple doses...

Yeah the way I see this, is that multiple dosing is likely the reason for the fail, assuming the first phase wasn't a scam. I think the chances...

From what I've read, shocks from headphones are just static shocks due to a variety of reasons. But just in case a shock did damage your hair...

It cant hurt to try. The more people who contact them, the more attention it gets. The more attention it gets, the better. Squeaky wheel gets...

I hope you are able to get this done! Your story and situation sounds horrible. I'm confident that this drug can at least make a significant...

Yes they are doing multiple dosing on humans. I do not think this is a concern. It only explains why they didn't maybe do multiple dosing on...

I personally believe that you are actually going to be ok. As people have pointed out, you had some protection right away and quickly got doubled...

Based on the definition of what constitutes "significant" and "measurable" in a clinical setting, milder cases simply do not have enough room to...

Found the thread she talked about it in: https://www.tinnitustalk.com/threads/silence-after-4-5-years-medications-from-company-called-decola.43227/

I wouldn't let that concern you much. His statements have to be conservative in order to avoid legal trouble. Assuming everything goes smooth, it...