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I should have been more explicit. My tinnitus is from noise exposure, no question about that. I was simply pointing out that I had tinnitus both while taking Enbrel and after stopping it, and I noticed no changes in my tinnitus.

My $0.02: I believe if this had a positive effect on tinnitus, we would know about it already. Enbrel has been on the market since the late 1990s with hundreds of thousands of users. Given the prevalence of tinnitus in the broader population, you would think the word would be out by now if there...

An interesting watch:

On the topic of drug delivery through the round window discussed earlier in this thread, this is pretty interesting: https://www.cilcare.com/2025/06/23/cilcare-launches-a-groundbreaking-3d-bioprinting-project-with-human-cells-to-advance-therapies-for-hearing-disorders/

I use a small, disc-shaped Jabra speaker with USB and Bluetooth. It sounds much better than the computer’s built-in speakers, providing a more mellow sound.

I’ve recently had to deal with this situation—I have reactive tinnitus that worsens with continuous ambient noise. For example, when I’m driving or on a plane, I need to use earplugs. However, this creates the opposite problem, as the noise isolation also causes my tinnitus to ramp up. It’s...

I would love to be wrong, but I do not think any weakening of the FDA will make much of a difference. I would love to see Lenire, with their fresh influx of funding, $10 million on top of the previous $33 million, license the technology from the University of Michigan for a next generation...

I've put it out of my mind and won't be holding my breath—if it happens, it happens. Any of the other approaches discussed in other threads on Tinnitus Talk are likely to come to market sooner. Everything that could be discussed has already been covered, so we might as well close this thread...

I've got a Baratza, too. After many, many years of using a cheap spinning blade type, I don't know how I survived. It was one of my better kitchen appliance purchases — there's no going back!

I've also been inquiring about this. The way they explained it to me, and I don't quite understand it fully, is that you don't need to suffer from migraines for it to work but that tinnitus involves some of the same pathways in the brain as migraines. Therefore, migraine drug treatments can...

I wouldn't be surprised if Auricle were leveraging the expertise of their development/manufacturing partner who also provides FDA approval support, in2being. It would make sense for Auricle to use in2being given their familiarity with the details of the device and experience with the process...

Admittedly, it's a sample size of one, but unfortunately, this didn't do anything for me. Maybe the weird sensation of sounds coming from the wrong direction could provide a distraction for people with mild/moderate tinnitus, but I'm not in that category. Anyway, not to take from the...

Looking at their website, they've listed 25 potential disorders that their KCC2 development might address, but no mention of tinnitus :( Another case of off-label experimentation if it ever comes to market?

It's been a while since I worked on Bluetooth audio. Still, I do know many Bluetooth codecs are available, with different levels of audio quality and latency depending on the type of compression/decompression used. It's not so much the latency itself that matters (this can range from 30-200 ms)...

I won't be surprised if you're right—I'm only trying it because it's low-risk, and I have some time on my hands right now. I'll update you in a couple of weeks. However, I don't think cross hearing aids are the same thing. I thought they re-route sound from the side of the bad ear to the good...

I bought the same headphones as used in the study - Peltor Tactical 300 and disassembled them to get access to the microphones and circuit board: Desolder the wires from left and right microphones from the left and right PCB Attach extension wires to the microphones Solder the wires from the...

Here goes nothing - my weekend project! Very weird walking around with these on - my own footsteps coming from the wrong direction and need to be very careful with traffic :)

For those interested, the patent application is quite informative. See the attached file. In addition to the simple method used in the trial, where the left and right microphones were reversed, he talks about further refinements to only reverse frequencies in the range of the person's tinnitus...

Regarding the points above describing various inconsistencies in results, I have to hope that during all this time we're left waiting, there's some work going on to refine and fine-tune the treatment parameters for optimal results. It'd be pretty disappointing if the only thing happening is...

You could look into an old-fashioned 'dental bridge' or even a partial/single-tooth denture rather than an implant. It's worth talking to different dentists, as their approaches can vary wildly, and, much as I hate to say it, some of the more unscrupulous ones favor the more expensive...

Worth a listen - very interesting: → Our Vice President, Clinical Operations and Development, Rachel Haines, was invited to speak on First-in-Human Podcast by Vial

This is an incredible breakthrough. Noise-induced and other modalities will follow later (e.g., Rinri Therapeutics), but hopefully, this is the start. It's good to see that direct injection into the cochlea is the preferred delivery method. I wonder if Frequency Therapeutics would've had...

I'm exactly in the same position - at risk of Glaucoma with a large optic nerve cup-to-disc ratio, so even though my eye pressures are normal, I'm using Latanoprost to bring my eye pressures even lower as a preventative measure. I've been on it for about two years now with no obvious side...

Rinri Therapeutics Announces New Chair as It Approaches First Clinical Trial

There's an active thread already on here for rTMS, tACS, tDCS, etc., that's been going since 2012, quoting various studies, people's experiences, etc., with generally inconclusive or no positive results. Can anyone figure out what's different, if anything, this time?

Did it help at all?

And don't forget the 'other' Auricle (https://auricle.com/) is developing an implant that stimulates the cochlea externally to treat hearing loss that falls in the gray zone of not bad enough to justify a true cochlear implant. If successful, this may also offer the possibility of tinnitus relief.

Maybe @Hazel can reach out for another update from Dr. Shore after some appropriate time period has elapsed since the last one? It might also be worth reaching out to Neuromod. They're enjoying considerable success right now and, from looking at their company profile and hiring activities, seem...

Exact same for me.

You could well be right, but they are also actively hiring bio-med and other engineers right now. The job descriptions mention developing next-gen devices.

It will be interesting to see what Neuromod is up to with their Lenire in the meantime - revenue is rolling in, they have electrical, mechanical, bio-med and software engineers on staff who are presumably working on something - improvements to current device, next-gen device, etc?

I highly doubt a commercial plane is 90 dB in the cabin continuously. If that were the case, all passengers would suffer hearing damage on long flights. Maybe at takeoff and landing? Regarding car vs. plane, there should be no difference. All I know is my ears are more susceptible to damage, so...

No music for me, but I watch movies w/ subtitles. The noise from either will spike my tinnitus, but it's somewhat of a "damned if you do, damned if you don't situation" - sound deprivation will also elevate my tinnitus, but at least in that case, I know there's no danger of a permanent spike...

I have very reactive tinnitus that will spike from the background noise and, after serious initial concerns, have now completed many domestic and international flights over the last 2+ years using 3M earplugs with noise-cancelling headphones on top - the lack of sound input causes my tinnitus to...

While good to see, it's incredibly frustrating that none of them have direct interest in targeting tinnitus - they must figure there's no money in it.

Do please report back on how you do with the Gabapentin - thanks!

My thinking on this is that if the tinnitus level can be significantly reduced through this or whatever method, then the reactivity aspect should automatically become less because of the compression of the loudness range. E.g., imagine your tinnitus at its worst and that can be reduced to an...

Did you find an online source that it can be ordered from?

But hasn't Tzounopoulos concluded that Kv7.2 and Kv7.3 were the specific ones to go after? One concern I have with his work though is that it was focused on acute tinnitus cases (does a few weeks of tinnitus in a mouse translate to chronic tinnitus in a human?)

Agreed - not only do they need to bring the product to market, they now need to displace Lenire from a strong install base on top of that.

It's been said before, but I'll say it again - the most expedient and lowest risk approach to take, IMHO, would be to simply license the IP to Neuromod and sit back to enjoy the revenue stream. However, at this point I'd be surprised if Neuromod had any interest as they seem to be enjoying...

Even if it still has a ways to go (!), this is an exciting update. The technology could be a genuine gamechanger and, frankly, a treatment I'd have a lot more confidence in than Neurolink...

I just put a few dabs on the earplug. It doesn't need much, and no need to put it in your ear. However, as @kingsfan says above, it does leave residue that needs to be wiped off so I'm going to try the other product he recommends and see how it compares.

I was able to improve the sealing of my custom earplugs with this product. It's expensive for a tiny tube, but did reduce the occlusion effect a small but noticeable amount and also makes the plugs much easier to get in and out.

Regarding the above pipeline for three tinnitus drugs, it's interesting to note that with their GW-TT2 candidate they talk about repurposing existing FDA approved drugs for tinnitus via nasal delivery. GW-TT23 is also nasal delivery, and GX-TT5 is based on gene therapy. Patents pending, so no...

Some updates on their tinnitus related product pipeline: https://www.gatewaybiotechnology.com/services/

I've been in touch with Dr. Cheung on and off about this. His method is invasive (similar to above). Further trials were on hold due to COVID-19, but more recently (June), he told me that he received, in his words, "surprisingly mixed reviews" in response to his NIH grant application to continue...

Nice little test on this website that will demonstrate what 6 dB increments in volume sound like - scroll down the page and click on the log level test. Please be careful with your speaker/headset volume setting before clicking: AudioCheck: The Non-Linearities of the Human Ear

Got it - thanks.

There's a startup looking to develop just that (coincidentally sharing the same name with Susan Shore's enterprise): Website: Auricle YCombinator: Auricle LinkedIn: Francis Wong (CEO of Auricle)

in the end, it all boils down to money - bringing the product from prototype stage to something that can be manufactured reliably in volume, FDA (and other) regulatory approvals, launch onto market, enlisting audiologists and providing them with support, training, etc. It all adds up, that's...

Probably worth keeping an eye on this (or other similar venture funding focused sites) for funding status, etc (last funding round was $350K in 2021): PitchBook: Auricle Inc.

The other big unknown is Auricle, the company. No mention of funding on any of the Angel investor databases, the only known employee is the CEO (and maybe one of the PhD students involved in the study whose LinkedIn profile lists him as Head of Engineering for Auricle). It takes a long time and...

In the future, maybe you won't need to trade off - this newly formed startup are working on an implant that stimulates the outside of the cochlea to restore high frequencies without damaging residual hearing: Stanford University: Extracochlear neurostimulation - Auricle Y Combinator: Auricle...

It'll be very interesting to see how this develops. For example, if the Mayo Clinic trial is successful, is it something they may be allowed to offer patients as a treatment, or will it need to go through further trials, FDA approval, etc. In many ways, it's a new application for existing...

Keep an eye also on Biohaven - BHV7000/7010. They are moving aggressively in this space with an expedited trial schedule, a product they claim is better than XEN1101 and have indicated the possibility of trialing it for other conditions later. See the BHV7000 thread for more information.

From their latest investor deck in January - moving quickly:

I took Enbrel (Etanercept) for 10 years and first developed tinnitus (noise induced) while on it. I came off Enbrel in 2018 due to being in full remission for my rheumatoid related condition but didn't notice any difference to my tinnitus (it was quite mild at the time). I've been tempted to...

This pretty much sums it up! I'm just happy that it's now 2023 and we're starting to have some options to look forward to. After multiple disappointments from other potential treatments, I'm just happy to know that the research looks ever more robust and a tinnitus specific treatment is, in...